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Oral Botanical Supplements

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Integrative Dermatology
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Abstract

Phytomedicine is the use of botanicals for medicinal purposes and has been used effectively for many centuries for skin disorders. Western herbal medicine is often used singly, while Eastern herbal medicines, such as in Chinese traditional medicine, are often used in combination with specific herbs. Many plants seem to have inhibitory effects on the growth of bacteria, fungi, and viruses in vitro. While herbs are generally less potent than laboratory-derived pharmaceutical medications, they also typically have lesser side effects. Integrative dermatology can utilize the best of both to help the patient (Zamani et al. Acta Med Iran 50(2):101–106, 2012; Norman, Integrative dermatology. Oxford University Press, Oxford, 2014).

Adaptogens can be defined as substances that enable an increase in the human’s body resistance to various chemical, biological, and physical stressors. By their anti-inflammatory and antibacterial properties, some adaptogens may play a role as an adjuvant therapy for acne and rosacea treatments.

While there is little clinical evidence about the effectiveness and safety of plants in the treatment of acne and other skin infections (Nasri et al. Jundishapur J Microbiol 8(11):e25580, 2015), herbs have gained popularity in the push toward a more “natural” approach.

In this chapter, we will discuss the use of certain herbs in treating acne including di-indolyl methane, chasteberry, adaptogens, rhodiola, ashwagandha, CBD, turmeric, and schisandra.

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References

  1. Zamani M, Neghab N, Torabian S. Therapeutic effect of Vitex agnus-castus in patients with premenstrual syndrome. Acta Med Iran. 2012;50(2):101–6.

    PubMed  Google Scholar 

  2. Norman RA. Integrative dermatology. Oxford: Oxford University Press; 2014.

    Google Scholar 

  3. Nasri H, Bahmani M, Shahinfard N, Moradi Nafchi A, Saberianpour S, Rafieian KM. Medicinal plants for the treatment of acne vulgaris: a review of recent evidences. Jundishapur J Microbiol. 2015;8(11):e25580.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Wu Y, Li RW, Huang H, Fletcher A, Yu L, Pham Q, et al. Inhibition of tumor growth by dietary indole-3-carbinol in a prostate cancer xenograft model may be associated with disrupted gut microbial interactions. Nutrients. 2019;11(2):467.

    Article  CAS  PubMed Central  Google Scholar 

  5. Licznerska B, Baer-Dubowska W. Indole-3-carbinol and its role in chronic diseases. In: Gupta SC, Prasad S, Aggarwal BB, editors. Anti-inflammatory nutraceuticals and chronic diseases. Philadelphia: Springer; 2016. p. 131–54.

    Chapter  Google Scholar 

  6. Katz E, Nisani S, Chamovitz DA. Indole-3-carbinol: a plant hormone combatting cancer. F1000Res. 2018;7. https://doi.org/10.12688/f1000research.14127.1.

  7. Schulz V, Hänsel R, Blumenthal M, Tyler VE. Rational phytotherapy: a reference guide for physicians and pharmacists. Heidelberg: Springer; 2004.

    Book  Google Scholar 

  8. Christie S, Walker AF. Vitex agnus-castus L. A review of its traditional and modern therapeutic use, current use from a survey of practitioners. Eur J Herb Med. 1997;3:29–45.

    Google Scholar 

  9. Du Mee C. Vitex agnus castus. Aust J Med Herbalism. 1993;5(3):63–5.

    Google Scholar 

  10. Blumenthal MJ. The complete German commission E monographs. Integrative Medicine Communication, 1999.

    Google Scholar 

  11. Kuruüzüm-Uz A, Ströch K, Demirezer LÖ, Zeeck A. Glucosides from Vitex agnus-castus. Phytochemistry. 2003;63(8):959–64.

    Article  PubMed  CAS  Google Scholar 

  12. Newall CA, Anderson LA, Phillipson JD. Herbal medicines. A guide for health-care professionals. London: Pharmaceutical Press; 1996.

    Google Scholar 

  13. Boon H, Smith M. The botanical pharmacy: the pharmacology of 47 common herbs. Kingston: Quarry press; 1999.

    Google Scholar 

  14. Sliutz G, Speiser P, Schultz AM, Spona J, Zeillinger R. Agnus castus extracts inhibit prolactin secretion of rat pituitary cells. Horm Metab Res. 1993;25(5):253–5.

    Article  CAS  PubMed  Google Scholar 

  15. Jarry H, Leonhardt S, Gorkow C, Wuttke WJ. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol. 1994;102(6):448–54.

    Article  CAS  PubMed  Google Scholar 

  16. Wuttke W, Gorkow C, Jarry H. Dopaminergic compounds in Vitex agnus castus. In: Loew D, Rietbrock N, editors. Phytopharmaka in Forschung und klinischer Anwendung. Heidelberg: Steinkopff; 1995. p. 81–91.

    Chapter  Google Scholar 

  17. Serri O, Chik CL, Ur E, Ezzat SJC. Diagnosis and management of hyperprolactinemia. CMAJ. 2003;169(6):575–81.

    PubMed  PubMed Central  Google Scholar 

  18. Daniele C, Coon JT, Pittler MH, Ernst EJ. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005;28(4):319–32.

    Article  PubMed  Google Scholar 

  19. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med. 2000;9(3):315–20.

    Article  CAS  PubMed  Google Scholar 

  20. Berger D, Schaffner W, Schrader E, Meier B, Brattstrom A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet. 2000;264(3):150–3.

    Article  CAS  PubMed  Google Scholar 

  21. van Die MD, Burger HG, Teede HJ, Bone KM. Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints. J Altern Complement Med. 2009;15(8):853–62.

    Article  PubMed  Google Scholar 

  22. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003;18(3):191–5.

    Article  CAS  PubMed  Google Scholar 

  23. Freeman EW. Premenstrual syndrome and premenstrual dysphoric disorder: definitions and diagnosis. Psychoneuroendocrinology. 2003;28(Suppl 3):25–37.

    Article  PubMed  Google Scholar 

  24. Lauritzen C, Reuter HD, Repges R, Bohnert KJ, Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxine. Phytomedicine. 1997;4(3):183–9.

    Article  CAS  PubMed  Google Scholar 

  25. Bedi MK, Shenefelt PD. Herbal therapy in dermatology. Arch Dermatol. 2002;138(2):232–42.

    Article  PubMed  Google Scholar 

  26. Tarkowská D, Strnad M. Plant ecdysteroids; plant sterols with intriguing distributions biological effects and relations to plant hormones. Planta. 2016;244(3):545–55.

    Article  PubMed  CAS  Google Scholar 

  27. Kaur P, Robin, Makanjuola VO, Arora R, Singh B, Arora S. Immunopotentiating significance of conventionally used plants adaptogens as modulators in biochemical and molecular signaling pathways in cell mediated processes. Biomed Pharmacother. 2017;95:1815–29.

    Article  CAS  PubMed  Google Scholar 

  28. Chen Y, Lyga J. Brain-skin connection: stress, inflammation and skin aging. Inflamm Allergy Drug Targets. 2014;13(3):177–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Bhuchar S, Katta R, Wolf J. Complementary and alternative medicine in dermatology: an overview of selected modalities for the practicing dermatologist. Am J Clin Dermatol. 2012;13(5):311–7.

    Article  PubMed  Google Scholar 

  30. Dobrek T. The outline of stress pathophysiology and pharmacodynamic action of plant based eustressors - adaptogens. Pol Merkur Lekarski. 2019;46(273):103–8.

    PubMed  Google Scholar 

  31. National Rosacea Society. Studies find rosacea may lead to increased oxidative stress, 2019. Available at: http://www.rosacea.org/blog/2019/april/study-finds-rosacea-may-lead-increased-oxidative-stress-041519.

  32. Sener S, Akbas A, Kilinc F, Baran P, Erel O, Aktas A. Thiol/disulfide homeostasis as a marker of oxidative stress in rosacea: a controlled spectrophotometric study. Cutan Ocul Toxicol. 2019;38(1):55–8.

    Article  CAS  PubMed  Google Scholar 

  33. Gur TF, Erdemir AV, Gurel MS, Kocyigit A, Guler EM, Erdil D. The investigation of the relationships of Demodex density with inflammatory response and oxidative stress in rosacea. Arch Dermatol Res. 2018;310(9):759–67.

    Article  CAS  Google Scholar 

  34. Zoubolis CC, Seltmann H, Hiroi N, Chen WC, Young M, Oeff M, et al. Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A. 2002;99(10):7148–53.

    Article  CAS  Google Scholar 

  35. Zhou CL, Yu X-J, Chen L-M, Jiang H, Li C-Y. Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes. Regul Pept. 2010;160(1–3):115–20.

    Article  CAS  PubMed  Google Scholar 

  36. Zhong X, Lin S, Funk WE, Hou L. Environmental occupational exposure to chemicals and telomere length in human studies. Occup Environ Med. 2013;70(10):743–9.

    Article  CAS  Google Scholar 

  37. Boesten DM, de Vos-Houben JM, Timmermans L, den Hartog GJM, Bast A, Hageman GJ. Accelerated aging during chronic oxidative stress: a role for PARP-1. Oxidative Med Cell Longev. 2013;2013:680414. https://doi.org/10.1155/2013/680414.

    Article  CAS  Google Scholar 

  38. Tyrka AR, Price LH, Kao H-T, Porton B, Marsella SA, Carpenter LL. Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biol Psychiatry. 2010;67(6):531–4.

    Article  CAS  PubMed  Google Scholar 

  39. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017;1401(1):49–64.

    Article  CAS  PubMed  Google Scholar 

  40. Panossian A, Wickman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481–93.

    Article  CAS  PubMed  Google Scholar 

  41. Kosakowska O, Bączek K, Przybył JL, Pióro-Jabrucka E, Czupa W, Synowiec A, et al. Antioxidant and antibacterial activity of Rose root (Rhodiola rosea L.) dry extracts. Molecules. 2018;23(7):1767.

    Article  PubMed Central  CAS  Google Scholar 

  42. Zhou Q, Yin Z-P, Ma L, Zhao W, Hao H-W, Li H-L. Free radical-scavenging activities of oligomeric proanthocyanidin from Rhodiola rosea L. and its antioxidant effects in vivo. Nat Prod Res. 2014;28(24):1–3.

    Article  CAS  Google Scholar 

  43. Committee on Herbal Medicinal Products. Community herbal monograph on Rhodiola rosea L., Rhizoma ex Radix. Committee on herbal medicine. London: European Medicines Agency; 2012.

    Google Scholar 

  44. Committee on Herbal Medicinal Products. Reflection paper on the adaptogenic concept. London: European Medicines Agency; 2008.

    Google Scholar 

  45. Ma Y-C, Wang X-Q, Hou FF, Ma J, Luo M, Lu S, et al. Rapid resolution liquid chromatography (RRLC) analysis for quality control of Rhodiola rosea roots and commercial standardized products. Nat Prod Commun. 2011;6(5):645–50.

    CAS  PubMed  Google Scholar 

  46. Kim J. Review of the innate immune response in acne vulgaris: activation of toll -like receptor2 in acne triggers inflammatory cytokine responses. Dermatology (Basel). 2005;211:193–8.

    Article  CAS  Google Scholar 

  47. Abeyama K, Eng W, Jester JV, Vink AA, Edelbaum D, Cockerell CJ, et al. A role for NF-Kappa B- dependent gene transactivation in sunburn. J Clin Invest. 2000;105(12):1751–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Guo M, An F, Wei X, Hong M, Lu Y. Comparative effects of schisandrin A,B and C on acne related inflammation. Inflammation. 2017;40(6):2063–172.

    Article  CAS  Google Scholar 

  49. Lam PY, Yan CW, Chiu PY, Leung HY, Ko KM. Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue. Fitoterapia. 2011;82(3):393–400.

    Article  CAS  PubMed  Google Scholar 

  50. Guo M, Lu Y, Yang J, Zhao X, Lu Y. Inhibitory effects of Schisandra chinensis extract on acne-related inflammation and UVB-induced photo-aging. Pharm Biol. 2016;54(12):2987–94.

    Article  CAS  PubMed  Google Scholar 

  51. Bhattacharya SK, Kaur R, Ghosal S. Antistress activity of sitoindosides VII and VIII: new acylsterylglusides from Withania somnifera. Phytother Res. 1987;1:32–7.

    Article  CAS  Google Scholar 

  52. Oláh A, Markovics A, Szabó-Papp J, Szabó PT, Stott C, Zoubouliset CC, et al. Differential effectiveness of selected non -psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrheic skin and acne treatment. Exp Dermatol. 2016;25(9):701–7.

    Article  PubMed  CAS  Google Scholar 

  53. Oláh A, Rolf P, Biró T. Cannabidiol exerts sebostatic and anti-inflammatory effects on human sebocytes. J Clin Invest. 2014;124(9):3713–24.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  54. Sishodia S. Molecular mechanisms of curcumin action: gene expression. Biofactors. 2013;39(1):37–55.

    Article  CAS  Google Scholar 

  55. Nakamura K, Yasunaga Y, Segawa T, Ko D, Moul JW, Srivastava S, et al. Curcumin down-regulates AR gene expression and activation in prostate cell lines. Int J Oncol. 2002;21(4):825–30.

    CAS  PubMed  Google Scholar 

  56. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353–6.

    Article  CAS  PubMed  Google Scholar 

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Solomon, M., Leite, A. (2021). Oral Botanical Supplements. In: Rupani, R.N., Lio, P.A. (eds) Integrative Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-58954-7_3

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  • DOI: https://doi.org/10.1007/978-3-030-58954-7_3

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