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SPECT and PET in Late-Life Depression

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PET and SPECT in Psychiatry

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Abstract

Late-onset late-life depression (LLD, depression with an age of onset above 60 years) appears to differ from depression with early onset in its association with cerebral small vessel disease, beta-amyloid and tau deposition, and neurodegenerative processes. Multimodality imaging (SPECT, PET, MRI) supports this concept and the notion that late-life depression relies on dysfunctioning of the frontal lobe, but also highlights that mechanisms underlying late-onset depression are heterogeneous and diverse. The future of PET and SPECT imaging in depression research relies on progress in data analysis, the development of novel molecular probes for specific cerebral targets, and combination of different imaging modalities (e.g., PET and MRI). Relatively unexplored areas for future research are gender differences, longitudinal changes of brain function associated with subclinical and clinical depression, and analysis of the default network activity.

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References

  • Adams KB (2001) Depressive symptoms, depletion, or developmental change? Withdrawal, apathy, and lack of vigor in the geriatric depression scale. Gerontologist 41:768–777

    Article  CAS  PubMed  Google Scholar 

  • Akiyama H, Hashimoto H, Kawabe J, Higashiyama S, Kai T, Kataoka K et al (2008) The relationship between depressive symptoms and prefrontal hypoperfusion demonstrated by eZIS in patients with DAT. Neurosci Lett 441:328–331

    Article  CAS  PubMed  Google Scholar 

  • Alexopoulos GS (2005) Depression in the elderly. Lancet 365:1961–1970

    Article  PubMed  Google Scholar 

  • Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M (1997a) ‘Vascular depression’ hypothesis. Arch Gen Psychiatry 54:915–922

    Article  CAS  PubMed  Google Scholar 

  • Alexopoulos GS, Meyers BS, Young RC, Kakuma T, Silbersweig D, Charlson M (1997b) Clinically defined vascular depression. Am J Psychiatry 154:562–565

    Article  CAS  PubMed  Google Scholar 

  • Alexopoulos GS, Kiosses DN, Klimstra S, Kalayam B, Bruce ML (2002) Clinical presentation of the “depression-executive dysfunction syndrome” of late life. Am J Geriatr Psychiatry 10:98–106

    PubMed  Google Scholar 

  • Amen DG, Krishnamani P, Meysami S, Newberg A, Raji CA (2017) Classification of depression, cognitive disorders, and co-morbid depression and cognitive disorders with perfusion SPECT neuroimaging. J Alzheimers Dis 57:253–266

    Article  PubMed  Google Scholar 

  • Andreescu C, Lenze EJ, Dew MA, Begley AE, Mulsant BH, Dombrovski AY et al (2007) Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study. Br J Psychiatry 190:344–349

    Article  PubMed  Google Scholar 

  • de Asis JM, Stern E, Alexopoulos GS, Pan H, Van Gorp W, Blumberg H et al (2001) Hippocampal and anterior cingulate activation deficits in patients with geriatric depression. Am J Psychiatry 158:1321–1323

    Article  PubMed  Google Scholar 

  • Auning E, Selnes P, Grambaite R, Saltyte BJ, Haram A, Lovli SA et al (2015) Neurobiological correlates of depressive symptoms in people with subjective and mild cognitive impairment. Acta Psychiatr Scand 131:139–147

    Article  CAS  PubMed  Google Scholar 

  • Awata S, Ito H, Konno M, Ono S, Kawashima R, Fukuda H et al (1998) Regional cerebral blood flow abnormalities in late-life depression: relation to refractoriness and chronification. Psychiatry Clin Neurosci 52:97–105

    Article  CAS  PubMed  Google Scholar 

  • Awata S, Konno M, Kawashima R, Suzuki K, Sato T, Matsuoka H et al (2002) Changes in regional cerebral blood flow abnormalities in late-life depression following response to electroconvulsive therapy. Psychiatry Clin Neurosci 56:31–40

    Article  PubMed  Google Scholar 

  • Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TLS et al (2016) Mood changes in cognitively normal older adults are linked to Alzheimer disease biomarker levels. Am J Geriatr Psychiatry 24:1095–1104

    Article  PubMed  PubMed Central  Google Scholar 

  • Baldwin RC, Tomenson B (1995) Depression in later life. A comparison of symptoms and risk factors in early and late onset cases. Br J Psychiatry 167:649–652

    Article  CAS  PubMed  Google Scholar 

  • Baldwin R, Jeffries S, Jackson A, Sutcliffe C, Thacker N, Scott M et al (2004) Treatment response in late-onset depression: relationship to neuropsychological, neuroradiological and vascular risk factors. Psychol Med 34:125–136

    Article  CAS  PubMed  Google Scholar 

  • Baron JC, Lebrun-Grandie P, Collard P, Crouzel C, Mestelan G, Bousser MG (1982) Noninvasive measurement of blood flow, oxygen consumption, and glucose utilization in the same brain regions in man by positron emission tomography: concise communication. J Nucl Med 23:391–399

    CAS  PubMed  Google Scholar 

  • Beekman AT, Kriegsman DM, Deeg DJ, van Tilburg W (1995) The association of physical health and depressive symptoms in the older population: age and sex differences. Soc Psychiatry Psychiatr Epidemiol 30:32–38

    Article  CAS  PubMed  Google Scholar 

  • Beekman AT, Copeland JR, Prince MJ (1999) Review of community prevalence of depression in later life. Br J Psychiatry 174:307–311

    Article  CAS  PubMed  Google Scholar 

  • Beekman AT, Geerlings SW, Deeg DJ, Smit JH, Schoevers RS, de Beurs E et al (2002) The natural history of late-life depression: a 6-year prospective study in the community. Arch Gen Psychiatry 59:605–611

    Article  PubMed  Google Scholar 

  • Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RS, Dolan RJ (1992) The anatomy of melancholia—focal abnormalities of cerebral blood flow in major depression. Psychol Med 22:607–615

    Article  CAS  PubMed  Google Scholar 

  • Bohnen NI, Kaufer DI, Hendrickson R, Constantine GM, Mathis CA, Moore RY (2007) Cortical cholinergic denervation is associated with depressive symptoms in Parkinson’s disease and parkinsonian dementia. J Neurol Neurosurg Psychiatry 78:641–643

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bonne O, Krausz Y, Shapira B, Bocher M, Karger H, Gorfine M et al (1996) Increased cerebral blood flow in depressed patients responding to electroconvulsive therapy. J Nucl Med 37:1075–1080

    CAS  PubMed  Google Scholar 

  • Bouckaert F, Emsell L, Vansteelandt K, De Winter FL, Van den SJ, Obbels J et al (2019) Electroconvulsive therapy response in late-life depression unaffected by age-related brain changes. J Affect Disord 251:114–120

    Article  PubMed  Google Scholar 

  • Brendel M, Pogarell O, Xiong G, Delker A, Bartenstein P, Rominger A (2015) Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients. Eur J Nucl Med Mol Imaging 42:716–724

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brendel M, Sauerbeck J, Greven S, Kotz S, Scheiwein F, Blautzik J et al (2018) Serotonin selective reuptake inhibitor treatment improves cognition and Grey matter atrophy but not amyloid burden during two-year follow-up in mild cognitive impairment and Alzheimer’s disease patients with depressive symptoms. J Alzheimers Dis 65:793–806

    Article  CAS  PubMed  Google Scholar 

  • Brodaty H, Peters K, Boyce P, Hickie I, Parker G, Mitchell P et al (1991) Age and depression. J Affect Disord 23:137–149

    Article  CAS  PubMed  Google Scholar 

  • Brodaty H, Luscombe G, Parker G, Wilhelm K, Hickie I, Austin MP et al (1997) Increased rate of psychosis and psychomotor change in depression with age. Psychol Med 27:1205–1213

    Article  CAS  PubMed  Google Scholar 

  • Brodaty H, Luscombe G, Parker G, Wilhelm K, Hickie I, Austin MP et al (2001) Early and late onset depression in old age: different aetiologies, same phenomenology. J Affect Disord 66:225–236

    Article  CAS  PubMed  Google Scholar 

  • Butters MA, Klunk WE, Mathis CA, Price JC, Ziolko SK, Hoge JA et al (2008) Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh compound-B. Alzheimer Dis Assoc Disord 22:261–268

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen ST, Siddarth P, Saito NY, Rueda F, Haight T, Ercoli LM et al (2014) Psychological well-being and regional brain amyloid and tau in mild cognitive impairment. Am J Geriatr Psychiatry 22:362–369

    Article  PubMed  Google Scholar 

  • Cho MJ, Lyoo IK, Lee DW, Kwon JS, Lee JS, Lee DS et al (2002) Brain single photon emission computed tomography findings in depressive pseudodementia patients. J Affect Disord 69:159–166

    Article  PubMed  Google Scholar 

  • Comijs HC, Jonker C, Beekman AT, Deeg DJ (2001) The association between depressive symptoms and cognitive decline in community-dwelling elderly persons. Int J Geriatr Psychiatry 16:361–367

    Article  CAS  PubMed  Google Scholar 

  • Curran SM, Murray CM, Van Beck M, Dougall N, O’Carroll RE, Austin MP et al (1993) A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia. Br J Psychiatry 163:155–165

    Article  CAS  PubMed  Google Scholar 

  • Dal Forno G, Palermo MT, Donohue JE, Karagiozis H, Zonderman AB, Kawas CH (2005) Depressive symptoms, sex, and risk for Alzheimer’s disease. Ann Neurol 57:381–387

    Article  PubMed  Google Scholar 

  • De Winter FL, Emsell L, Bouckaert F, Claes L, Jain S, Farrar G et al (2017) No association of lower hippocampal volume with Alzheimer’s disease pathology in late-life depression. Am J Psychiatry 174:237–245

    Article  PubMed  Google Scholar 

  • DeLorenzo C, Sovago J, Gardus J, Xu J, Yang J, Behrje R et al (2015) Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [(1)(1)C]ABP688. Transl Psychiatry 5:e693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Devanand DP, Pelton GH, Marston K, Camacho Y, Roose SP, Stern Y et al (2003) Sertraline treatment of elderly patients with depression and cognitive impairment. Int J Geriatr Psychiatry 18:123–130

    Article  CAS  PubMed  Google Scholar 

  • Ding YS, Lin KS, Logan J, Benveniste H, Carter P (2005) Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine. J Neurochem 94:337–351

    Article  CAS  PubMed  Google Scholar 

  • Diniz BS, Sibille E, Ding Y, Tseng G, Aizenstein HJ, Lotrich F et al (2015) Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression. Mol Psychiatry 20:594–601

    Article  CAS  PubMed  Google Scholar 

  • Dolan RJ, Bench CJ, Brown RG, Scott LC, Frackowiak RS (1994) Neuropsychological dysfunction in depression: the relationship to regional cerebral blood flow. Psychol Med 24:849–857

    Article  CAS  PubMed  Google Scholar 

  • Dombrovski AY, Mulsant BH, Houck PR, Mazumdar S, Lenze EJ, Andreescu C et al (2007) Residual symptoms and recurrence during maintenance treatment of late-life depression. J Affect Disord 103:77–82

    Article  PubMed  PubMed Central  Google Scholar 

  • Dong JY, Zhang YH, Tong J, Qin LQ (2012) Depression and risk of stroke: a meta-analysis of prospective studies. Stroke 43:32–37

    Article  PubMed  Google Scholar 

  • Donovan NJ, Hsu DC, Dagley AS, Schultz AP, Amariglio RE, Mormino EC et al (2015) Depressive symptoms and biomarkers of Alzheimer’s disease in cognitively normal older adults. J Alzheimers Dis 46:63–73

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM et al (2018) Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults. Am J Psychiatry 175:530–537

    Article  PubMed  PubMed Central  Google Scholar 

  • Dotson VM, Beason-Held L, Kraut MA, Resnick SM (2009) Longitudinal study of chronic depressive symptoms and regional cerebral blood flow in older men and women. Int J Geriatr Psychiatry 24:809–819

    Article  PubMed  PubMed Central  Google Scholar 

  • Ebmeier KP, Prentice N, Ryman A, Halloran E, Rimmington JE, Best JK et al (1997) Temporal lobe abnormalities in dementia and depression: a study using high resolution single photon emission tomography and magnetic resonance imaging. J Neurol Neurosurg Psychiatry 63:597–604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ebmeier KP, Glabus MF, Prentice N, Ryman A, Goodwin GM (1998) A voxel-based analysis of cerebral perfusion in dementia and depression of old age. NeuroImage 7:199–208

    Article  CAS  PubMed  Google Scholar 

  • Eyre HA, Siddarth P, van Dyk K, St CN, Baune BT, Barrio JR et al (2017) Neural correlates of apathy in late-life depression: a pilot [(18) F]FDDNP positron emission tomography study. Psychogeriatrics 17:186–193

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferrari AJ, Somerville AJ, Baxter AJ, Norman R, Patten SB, Vos T et al (2013) Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature. Psychol Med 43:471–481

    Article  CAS  PubMed  Google Scholar 

  • Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462–464

    Article  CAS  PubMed  Google Scholar 

  • Fuhrer R, Dufouil C, Dartigues JF (2003) Exploring sex differences in the relationship between depressive symptoms and dementia incidence: prospective results from the PAQUID study. J Am Geriatr Soc 51:1055–1063

    Article  PubMed  Google Scholar 

  • Fujimoto T, Takeuchi K, Matsumoto T, Fujita S, Honda K, Higashi Y et al (2008) Metabolic changes in the brain of patients with late-onset major depression. Psychiatry Res 164:48–57

    Article  CAS  PubMed  Google Scholar 

  • Gallo JJ, Rabins PV, Lyketsos CG, Tien AY, Anthony JC (1997) Depression without sadness: functional outcomes of nondysphoric depression in later life. J Am Geriatr Soc 45:570–578

    Article  CAS  PubMed  Google Scholar 

  • Galynker II, Dutta E, Vilkas N, Ongseng F, Finestone H, Gallagher R et al (2000) Hypofrontality and negative symptoms in patients with dementia of Alzheimer type. Neuropsychiatry Neuropsychol Behav Neurol 13:53–59

    CAS  PubMed  Google Scholar 

  • Ganguli M, Dodge HH, Mulsant BH (2002) Rates and predictors of mortality in an aging, rural, community-based cohort: the role of depression. Arch Gen Psychiatry 59:1046–1052

    Article  PubMed  Google Scholar 

  • Gao Y, Huang C, Zhao K, Ma L, Qiu X, Zhang L et al (2013) Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Int J Geriatr Psychiatry 28:441–449

    Article  PubMed  Google Scholar 

  • Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J et al (2017) Depressive symptoms and tau accumulation in the inferior temporal lobe and entorhinal cortex in cognitively normal older adults: a pilot study. J Alzheimers Dis 59:975–985

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gross AL, Gallo JJ, Eaton WW (2010) Depression and cancer risk: 24 years of follow-up of the Baltimore epidemiologic catchment area sample. Cancer Causes Control 21:191–199

    Article  PubMed  Google Scholar 

  • Halloran E, Prentice N, Murray CL, O’Carroll RE, Glabus MF, Goodwin GM et al (1999) Follow-up study of depression in the elderly. Clinical and SPECT data. Br J Psychiatry 175:252–258

    Article  CAS  PubMed  Google Scholar 

  • Hammers DB, Atkinson TJ, Dalley BCA, Suhrie KR, Horn KP, Rasmussen KM et al (2017) Amyloid positivity using [18F]Flutemetamol-PET and cognitive deficits in nondemented community-dwelling older adults. Am J Alzheimers Dis Other Dement 32:320–328

    Article  Google Scholar 

  • Hanada K, Hosono M, Kudo T, Hitomi Y, Yagyu Y, Kirime E et al (2006) Regional cerebral blood flow in the assessment of major depression and Alzheimer’s disease in the early elderly. Nucl Med Commun 27:535–541

    Article  PubMed  Google Scholar 

  • Hanada H, Imanaga J, Yoshiiwa A, Yoshikawa T, Tanaka Y, Tsuru J et al (2013) The value of ethyl cysteinate dimer single photon emission computed tomography in predicting antidepressant treatment response in patients with major depression. Int J Geriatr Psychiatry 28:756–765

    Article  PubMed  Google Scholar 

  • Harrington KD, Gould E, Lim YY, Ames D, Pietrzak RH, Rembach A et al (2017) Amyloid burden and incident depressive symptoms in cognitively normal older adults. Int J Geriatr Psychiatry 32:455–463

    Article  PubMed  Google Scholar 

  • Hayashi S, Terada S, Sato S, Oshima E, Miki T, Yokota O et al (2016) Positive affect and regional cerebral blood flow in Alzheimer’s disease. Psychiatry Res Neuroimaging 256:15–20

    Article  PubMed  Google Scholar 

  • Hegeman JM, Kok RM, van der Mast RC, Giltay EJ (2012) Phenomenology of depression in older compared with younger adults: meta-analysis. Br J Psychiatry 200:275–281

    Article  CAS  PubMed  Google Scholar 

  • Herrmann LL, Goodwin GM, Ebmeier KP (2007) The cognitive neuropsychology of depression in the elderly. Psychol Med 37:1693–1702

    Article  PubMed  Google Scholar 

  • Herting B, Beuthien-Baumann B, Pottrich K, Donix M, Triemer A, Lampe JB et al (2007) Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes. Mov Disord 22:490–497

    Article  PubMed  Google Scholar 

  • Hickie I, Scott E (1998) Late-onset depressive disorders: a preventable variant of cerebrovascular disease? Psychol Med 28:1007–1013

    Article  CAS  PubMed  Google Scholar 

  • Hickie I, Hickie C, Bennett B, Wakefield D, Silove D, Mitchell P et al (1995a) Biochemical correlates of in vivo cell-mediated immune dysfunction in patients with depression: a preliminary report. Int J Immunopharmacol 17:685–690

    Article  CAS  PubMed  Google Scholar 

  • Hickie I, Scott E, Mitchell P, Wilhelm K, Austin MP, Bennett B (1995b) Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression. Biol Psychiatry 37:151–160

    Article  CAS  PubMed  Google Scholar 

  • Hickie IB, Naismith SL, Ward PB, Little CL, Pearson M, Scott EM et al (2007) Psychomotor slowing in older patients with major depression: relationships with blood flow in the caudate nucleus and white matter lesions. Psychiatry Res 155:211–220

    Article  PubMed  Google Scholar 

  • Hickie IB, Naismith SL, Norrie LM, Scott EM (2009) Managing depression across the life cycle: new strategies for clinicians and their patients. Intern Med J 39:720–727

    Article  CAS  PubMed  Google Scholar 

  • Hirono N, Mori E, Ishii K, Ikejiri Y, Imamura T, Shimomura T et al (1998) Frontal lobe hypometabolism and depression in Alzheimer’s disease. Neurology 50:380–383

    Article  CAS  PubMed  Google Scholar 

  • Holthoff VA, Beuthien-Baumann B, Kalbe E, Ludecke S, Lenz O, Zundorf G et al (2005) Regional cerebral metabolism in early Alzheimer’s disease with clinically significant apathy or depression. Biol Psychiatry 57:412–421

    Article  CAS  PubMed  Google Scholar 

  • Honda H, Terada S, Sato S, Oshima E, Ikeda C, Nagao S et al (2014) Subjective depressive mood and regional cerebral blood flow in mild Alzheimer’s disease. Int Psychogeriatr 26:817–823

    Article  PubMed  Google Scholar 

  • Ingvar DH (1979) “Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state. Acta Neurol Scand 60:12–25

    Article  CAS  PubMed  Google Scholar 

  • Ishizaki J, Yamamoto H, Takahashi T, Takeda M, Yano M, Mimura M (2008) Changes in regional cerebral blood flow following antidepressant treatment in late-life depression. Int J Geriatr Psychiatry 23:805–811

    Article  PubMed  Google Scholar 

  • Jagust WJ, Reed BR, Martin EM, Eberling JL, Nelson-Abbott RA (1992) Cognitive function and regional cerebral blood flow in Parkinson’s disease. Brain 115(Pt 2):521–537

    Article  PubMed  Google Scholar 

  • Kang JY, Lee JS, Kang H, Lee HW, Kim YK, Jeon HJ et al (2012) Regional cerebral blood flow abnormalities associated with apathy and depression in Alzheimer disease. Alzheimer Dis Assoc Disord 26:217–224

    Article  PubMed  Google Scholar 

  • Kataoka K, Hashimoto H, Kawabe J, Higashiyama S, Akiyama H, Shimada A et al (2010) Frontal hypoperfusion in depressed patients with dementia of Alzheimer type demonstrated on 3DSRT. Psychiatry Clin Neurosci 64:293–298

    Article  PubMed  Google Scholar 

  • Katon W, Russo J, Lin EH, Heckbert SR, Ciechanowski P, Ludman EJ et al (2009) Depression and diabetes: factors associated with major depression at five-year follow-up. Psychosomatics 50:570–579

    Article  PubMed  PubMed Central  Google Scholar 

  • Kendler KS, Gardner CO, Lichtenstein P (2008) A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation. Psychol Med 38:1567–1575

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kendler KS, Gardner CO, Fiske A, Gatz M (2009) Major depression and coronary artery disease in the Swedish twin registry: phenotypic, genetic, and environmental sources of comorbidity. Arch Gen Psychiatry 66:857–863

    Article  PubMed  PubMed Central  Google Scholar 

  • Kennedy GJ, Kelman HR, Thomas C (1991) Persistence and remission of depressive symptoms in late life. Am J Psychiatry 148:174–178

    CAS  PubMed  Google Scholar 

  • Kim HJ, Kang SJ, Kim C, Kim GH, Jeon S, Lee JM et al (2013) The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments. Neurobiol Aging 34:1913–1920

    Article  CAS  PubMed  Google Scholar 

  • Kim YD, Jeong HS, Song IU, Chung YA, Namgung E, Kim YD (2016a) Brain perfusion alterations in depressed patients with Parkinson’s disease. Ann Nucl Med 30:731–737

    Article  CAS  PubMed  Google Scholar 

  • Kim HG, Kong EJ, Cheon EJ, Kim HW, Koo BH (2016b) Association between cerebral amyloid deposition and clinical factors including cognitive function in geriatric depression: pilot study using amyloid positron emission tomography. Clin Psychopharmacol Neurosci 14:378–382

    Article  PubMed  PubMed Central  Google Scholar 

  • Kimura M, Shimoda K, Mizumura S, Tateno A, Fujito T, Mori T et al (2003) Regional cerebral blood flow in vascular depression assessed by 123I-IMP SPECT. J Nippon Med Sch 70:321–326

    Article  PubMed  Google Scholar 

  • Kohler S, van Boxtel MP, van Os J, Thomas AJ, O’Brien JT, Jolles J et al (2010a) Depressive symptoms and cognitive decline in community-dwelling older adults. J Am Geriatr Soc 58:873–879

    Article  PubMed  Google Scholar 

  • Kohler S, Thomas AJ, Barnett NA, O’Brien JT (2010b) The pattern and course of cognitive impairment in late-life depression. Psychol Med 40:591–602

    Article  CAS  PubMed  Google Scholar 

  • Krell-Roesch J, Ruider H, Lowe VJ, Stokin GB, Pink A, Roberts RO et al (2016) FDG-PET and neuropsychiatric symptoms among cognitively normal elderly persons: the Mayo Clinic study of aging. J Alzheimers Dis 53:1609–1616

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krishnan KR, Hays JC, Blazer DG (1997) MRI-defined vascular depression. Am J Psychiatry 154:497–501

    Article  CAS  PubMed  Google Scholar 

  • Kuhl DE, Metter EJ, Riege WH (1985) Patterns of cerebral glucose utilization in depression, multiple infarct dementia, and Alzheimer’s disease. Res Publ Assoc Res Nerv Ment Dis 63:211–226

    CAS  PubMed  Google Scholar 

  • Kumar A, Newberg A, Alavi A, Berlin J, Smith R, Reivich M (1993) Regional cerebral glucose metabolism in late-life depression and Alzheimer disease: a preliminary positron emission tomography study. Proc Natl Acad Sci U S A 90:7019–7023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumar A, Kepe V, Barrio JR, Siddarth P, Manoukian V, Elderkin-Thompson V et al (2011) Protein binding in patients with late-life depression. Arch Gen Psychiatry 68:1143–1150

    Article  PubMed  PubMed Central  Google Scholar 

  • Launes J, Sulkava R, Erkinjuntti T, Nikkinen P, Lindroth L, Liewendahl K et al (1991) 99Tcm-HMPAO SPECT in suspected dementia. Nucl Med Commun 12:757–765

    Article  CAS  PubMed  Google Scholar 

  • Lavretsky H, Kurbanyan K, Ballmaier M, Mintz J, Toga A, Kumar A (2004) Sex differences in brain structure in geriatric depression. Am J Geriatr Psychiatry 12:653–657

    Article  PubMed  Google Scholar 

  • Lavretsky H, Siddarth P, Kepe V, Ercoli LM, Miller KJ, Burggren AC et al (2009) Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults. Am J Geriatr Psychiatry 17:493–502

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee HS, Choo IH, Lee DY, Kim JW, Seo EH, Kim SG et al (2010) Frontal dysfunction underlies depression in mild cognitive impairment: a FDG-PET study. Psychiatry Investig 7:208–214

    Article  PubMed  PubMed Central  Google Scholar 

  • Lenze EJ, Schulz R, Martire LM, Zdaniuk B, Glass T, Kop WJ et al (2005) The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the cardiovascular health study. J Am Geriatr Soc 53:569–575

    Article  PubMed  Google Scholar 

  • Lesser IM, Mena I, Boone KB, Miller BL, Mehringer CM, Wohl M (1994) Reduction of cerebral blood flow in older depressed patients. Arch Gen Psychiatry 51:677–686

    Article  CAS  PubMed  Google Scholar 

  • Levy-Cooperman N, Burhan AM, Rafi-Tari S, Kusano M, Ramirez J, Caldwell C et al (2008) Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease. J Psychiatry Neurosci 33:218–226

    PubMed  PubMed Central  Google Scholar 

  • Liao YC, Liu RS, Lee YC, Sun CM, Liu CY, Wang PS et al (2003) Selective hypoperfusion of anterior cingulate gyrus in depressed AD patients: a brain SPECT finding by statistical parametric mapping. Dement Geriatr Cogn Disord 16:238–244

    Article  PubMed  Google Scholar 

  • Licht-Strunk E, van der Windt DA, van Marwijk HW, de Haan M, Beekman AT (2007) The prognosis of depression in older patients in general practice and the community. A systematic review. Fam Pract 24:168–180

    Article  PubMed  Google Scholar 

  • Lieberman A (2006) Are dementia and depression in Parkinson’s disease related? J Neurol Sci 248:138–142

    Article  PubMed  Google Scholar 

  • Liguori C, Pierantozzi M, Chiaravalloti A, Sancesario GM, Mercuri NB, Franchini F et al (2018) When cognitive decline and depression coexist in the elderly: CSF biomarkers analysis can differentiate Alzheimer’s disease from late-life depression. Front Aging Neurosci 10:38

    Article  PubMed  PubMed Central  Google Scholar 

  • Luppa M, Sikorski C, Luck T, Ehreke L, Konnopka A, Wiese B et al (2012) Age- and gender-specific prevalence of depression in latest-life—systematic review and meta-analysis. J Affect Disord 136:212–221

    Article  CAS  PubMed  Google Scholar 

  • Madsen K, Hasselbalch BJ, Frederiksen KS, Haahr ME, Gade A, Law I et al (2012) Lack of association between prior depressive episodes and cerebral [11C]PiB binding. Neurobiol Aging 33:2334–2342

    Article  CAS  PubMed  Google Scholar 

  • Marano CM, Workman CI, Kramer E, Hermann CR, Ma Y, Dhawan V et al (2013) Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. Int J Geriatr Psychiatry 28:417–423

    Article  PubMed  Google Scholar 

  • Marano CM, Workman CI, Lyman CH, Kramer E, Hermann CR, Ma Y et al (2014) The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging. Psychiatry Res 222:84–90

    Article  PubMed  PubMed Central  Google Scholar 

  • Mayberg HS, Starkstein SE, Sadzot B, Preziosi T, Andrezejewski PL, Dannals RF et al (1990) Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson’s disease. Ann Neurol 28:57–64

    Article  CAS  PubMed  Google Scholar 

  • Meijer A, Conradi HJ, Bos EH, Thombs BD, van Melle JP, de Jonge P (2011) Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research. Gen Hosp Psychiatry 33:203–216

    Article  PubMed  Google Scholar 

  • Mentis MJ, McIntosh AR, Perrine K, Dhawan V, Berlin B, Feigin A et al (2002) Relationships among the metabolic patterns that correlate with mnemonic, visuospatial, and mood symptoms in Parkinson’s disease. Am J Psychiatry 159:746–754

    Article  PubMed  Google Scholar 

  • Meyer PM, Strecker K, Kendziorra K, Becker G, Hesse S, Woelpl D et al (2009) Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease. Arch Gen Psychiatry 66:866–877

    Article  CAS  PubMed  Google Scholar 

  • Mezuk B, Eaton WW, Albrecht S, Golden SH (2008) Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 31:2383–2390

    Article  PubMed  PubMed Central  Google Scholar 

  • Mitchell AJ, Subramaniam H (2005) Prognosis of depression in old age compared to middle age: a systematic review of comparative studies. Am J Psychiatry 162:1588–1601

    Article  PubMed  Google Scholar 

  • Mueller TI, Kohn R, Leventhal N, Leon AC, Solomon D, Coryell W et al (2004) The course of depression in elderly patients. Am J Geriatr Psychiatry 12:22–29

    Article  PubMed  Google Scholar 

  • Nagafusa Y, Okamoto N, Sakamoto K, Yamashita F, Kawaguchi A, Higuchi T et al (2012) Assessment of cerebral blood flow findings using 99mTc-ECD single-photon emission computed tomography in patients diagnosed with major depressive disorder. J Affect Disord 140:296–299

    Article  PubMed  Google Scholar 

  • Naismith SL, Hickie IB, Turner K, Little CL, Winter V, Ward PB et al (2003) Neuropsychological performance in patients with depression is associated with clinical, etiological and genetic risk factors. J Clin Exp Neuropsychol 25:866–877

    Article  PubMed  Google Scholar 

  • Naismith SL, Hickie IB, Ward PB, Scott E, Little C (2006) Impaired implicit sequence learning in depression: a probe for frontostriatal dysfunction? Psychol Med 36:313–323

    Article  PubMed  Google Scholar 

  • Navarro V, Gasto C, Lomena F, Mateos JJ, Marcos T (2001) Frontal cerebral perfusion dysfunction in elderly late-onset major depression assessed by 99MTC-HMPAO SPECT. NeuroImage 14:202–205

    Article  CAS  PubMed  Google Scholar 

  • Navarro V, Gasto C, Lomena F, Mateos JJ, Marcos T, Portella MJ (2002) Normalization of frontal cerebral perfusion in remitted elderly major depression: a 12-month follow-up SPECT study. NeuroImage 16:781–787

    Article  PubMed  Google Scholar 

  • Navarro V, Gasto C, Lomena F, Mateos JJ, Portella MJ, Masana G et al (2004a) No brain perfusion impairment at long-term follow-up in elderly patients treated with electroconvulsive therapy for major depression. J ECT 20:89–93

    Article  PubMed  Google Scholar 

  • Navarro V, Gasto C, Lomena F, Torres X, Mateos JJ, Portella MJ et al (2004b) Prognostic value of frontal functional neuroimaging in late-onset severe major depression. Br J Psychiatry 184:306–311

    Article  PubMed  Google Scholar 

  • Newmann JP, Engel RJ, Jensen JE (1991) Age differences in depressive symptom experiences. J Gerontol 46:224–235

    Article  Google Scholar 

  • Nicholas CR, Hoscheidt SM, Clark LR, Racine AM, Berman SE, Koscik RL et al (2017) Positive affect predicts cerebral glucose metabolism in late middle-aged adults. Soc Cogn Affect Neurosci 12:993–1000

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Brien J, Desmond P, Ames D, Schweitzer I, Harrigan S, Tress B (1996) A magnetic resonance imaging study of white matter lesions in depression and Alzheimer’s disease. Br J Psychiatry 168:477–485

    Article  PubMed  Google Scholar 

  • Palhagen SE, Ekberg S, Walinder J, Granerus AK, Granerus G (2009) HMPAO SPECT in Parkinson’s disease (PD) with major depression (MD) before and after antidepressant treatment. J Neurol 256:1510–1518

    Article  PubMed  Google Scholar 

  • Perin S, Harrington KD, Lim YY, Ellis K, Ames D, Pietrzak RH et al (2018) Amyloid burden and incident depressive symptoms in preclinical Alzheimer’s disease. J Affect Disord 229:269–274

    Article  CAS  PubMed  Google Scholar 

  • Philpot MP, Banerjee S, Needham-Bennett H, Costa DC, Ell PJ (1993) 99mTc-HMPAO single photon emission tomography in late life depression: a pilot study of regional cerebral blood flow at rest and during a verbal fluency task. J Affect Disord 28:233–240

    Article  CAS  PubMed  Google Scholar 

  • Pisljar M, Pirtosek Z, Repovs G, Grgic M (2008) Executive dysfunction in late-onset depression. Psychiatr Danub 20:231–235

    PubMed  Google Scholar 

  • Prince MJ, Beekman AT, Deeg DJ, Fuhrer R, Kivela SL, Lawlor BA et al (1999) Depression symptoms in late life assessed using the EURO-D scale. Effect of age, gender and marital status in 14 European centres. Br J Psychiatry 174:339–345

    Article  CAS  PubMed  Google Scholar 

  • Ring HA, Bench CJ, Trimble MR, Brooks DJ, Frackowiak RS, Dolan RJ (1994) Depression in Parkinson’s disease. A positron emission study. Br J Psychiatry 165:333–339

    Article  CAS  PubMed  Google Scholar 

  • Ritchie K, Gilham C, Ledesert B, Touchon J, Kotzki PO (1999) Depressive illness, depressive symptomatology and regional cerebral blood flow in elderly people with sub-clinical cognitive impairment. Age Ageing 28:385–391

    Article  CAS  PubMed  Google Scholar 

  • Ruhé HG, Visser AKD, Frokjaer VG, Haarman BCM, Klein HC, Booij J (2020) Molecular imaging of depressive disorders. In: Dierckx RAJO, Otte A, De Vries EFJ, Van Waarde A (eds) PET and SPECT in psychiatry, 1st edn. Springer, Berlin, pp 93–172

    Google Scholar 

  • Sabbagh MN, Lynn P, Jhingran S, Massman P, Villanueva-Meyer J, Olup J et al (1997) Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 9:68–74

    Article  CAS  PubMed  Google Scholar 

  • Sackeim HA, Prohovnik I, Moeller JR, Brown RP, Apter S, Prudic J et al (1990) Regional cerebral blood flow in mood disorders. I. Comparison of major depressives and normal controls at rest. Arch Gen Psychiatry 47:60–70

    Article  CAS  PubMed  Google Scholar 

  • Sakurai R, Suzuki H, Fujiwara Y, Yasunaga M, Takeuchi R, Murayama Y et al (2017) Neural basis for the relationship between frequency of going outdoors and depressive mood in older adults. Int J Geriatr Psychiatry 32:589–595

    Article  PubMed  Google Scholar 

  • Salloway S, Malloy P, Kohn R, Gillard E, Duffy J, Rogg J et al (1996) MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology 46:1567–1574

    Article  CAS  PubMed  Google Scholar 

  • Schweitzer I, Tuckwell V, O’Brien J, Ames D (2002) Is late onset depression a prodrome to dementia? Int J Geriatr Psychiatry 17:997–1005

    Article  PubMed  Google Scholar 

  • Sheline YI, Barch DM, Garcia K, Gersing K, Pieper C, Welsh-Bohmer K et al (2006) Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed. Biol Psychiatry 60:58–65

    Article  PubMed  Google Scholar 

  • Sheline YI, Pieper CF, Barch DM, Welsh-Bohmer K, McKinstry RC, MacFall JR et al (2010) Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. Arch Gen Psychiatry 67:277–285

    Article  PubMed  PubMed Central  Google Scholar 

  • Siennicki-Lantz A, Ndre-Petersson L, Wollmer P, Elmstahl S (2013) Depressive symptoms, atherosclerotic burden and cerebral blood flow disturbances in a cohort of octogenarian men from a general population. BMC Psychiatry 13:347

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith GS, Kramer E, Ma Y, Kingsley P, Dhawan V, Chaly T et al (2009) The functional neuroanatomy of geriatric depression. Int J Geriatr Psychiatry 24:798–808

    Article  PubMed  PubMed Central  Google Scholar 

  • Sneed JR, Roose SP, Keilp JG, Krishnan KR, Alexopoulos GS, Sackeim HA (2007) Response inhibition predicts poor antidepressant treatment response in very old depressed patients. Am J Geriatr Psychiatry 15:553–563

    Article  PubMed  Google Scholar 

  • Soares JC, Mann JJ (1997) The anatomy of mood disorders—review of structural neuroimaging studies. Biol Psychiatry 41:86–106

    Article  CAS  PubMed  Google Scholar 

  • Staffen W, Bergmann J, Schonauer U, Zauner H, Kronbichler M, Golaszewski S et al (2009) Cerebral perfusion (HMPAO-SPECT) in patients with depression with cognitive impairment versus those with mild cognitive impairment and dementia of Alzheimer’s type: a semiquantitative and automated evaluation. Eur J Nucl Med Mol Imaging 36:801–810

    Article  CAS  PubMed  Google Scholar 

  • Steffens DC, Krishnan KR (1998) Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions. Biol Psychiatry 43:705–712

    Article  CAS  PubMed  Google Scholar 

  • Stoppe G, Staedt J, Kogler A, Schutze R, Kunert HJ, Sandrock D et al (1995) 99mTc-HMPAO-SPECT in the diagnosis of senile dementia of Alzheimer’s type—a study under clinical routine conditions. J Neural Transm Gen Sect 99:195–211

    Article  CAS  PubMed  Google Scholar 

  • Su L, Faluyi YO, Hong YT, Fryer TD, Mak E, Gabel S et al (2016) Neuroinflammatory and morphological changes in late-life depression: the NIMROD study. Br J Psychiatry 209:525–526

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tateno A, Sakayori T, Higuchi M, Suhara T, Ishihara K, Kumita S et al (2015) Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset. Int J Geriatr Psychiatry 30:720–728

    Article  PubMed  Google Scholar 

  • Thomas AJ, Gallagher P, Robinson LJ, Porter RJ, Young AH, Ferrier IN et al (2009) A comparison of neurocognitive impairment in younger and older adults with major depression. Psychol Med 39:725–733

    Article  CAS  PubMed  Google Scholar 

  • Upadhyaya AK, Bou-Saleh MT, Wilson K, Grime SJ, Critchley M (1990) A study of depression in old age using single-photon emission computerised tomography. Br J Psychiatry Suppl 157(9):76–81

    Article  Google Scholar 

  • Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A (2007) Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry 22:613–626

    Article  PubMed  Google Scholar 

  • Van Waarde A, Vaalburg W, Doze P, Bosker FJ, Elsinga PH (2004) PET imaging of beta-adrenoceptors in human brain: a realistic goal or a mirage? Curr Pharm Des 10:1519–1536

    Article  PubMed  Google Scholar 

  • Vardi N, Freedman N, Lester H, Gomori JM, Chisin R, Lerer B et al (2011) Hyperintensities on T2-weighted images in the basal ganglia of patients with major depression: cerebral perfusion and clinical implications. Psychiatry Res 192:125–130

    Article  PubMed  Google Scholar 

  • Vercelletto M, Martinez F, Lanier S, Magne C, Jaulin P, Bourin M (2002) Negative symptoms, depression and Alzheimer’s disease. Int J Geriatr Psychiatry 17:383–387

    Article  PubMed  Google Scholar 

  • Wolkowitz OM, Reus VI, Mellon SH (2011) Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci 13:25–39

    Article  PubMed  Google Scholar 

  • Wong CY, Thie J, Gaskill M, Ponto R, Hill J, Tian HY et al (2006) A statistical investigation of normal regional intra-subject heterogeneity of brain metabolism and perfusion by F-18 FDG and O-15 H2O PET imaging. BMC Nucl Med 6:4

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu KY, Hsiao IT, Chen CS, Chen CH, Hsieh CJ, Wai YY et al (2014) Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging 41:714–722

    Article  CAS  PubMed  Google Scholar 

  • Wu KY, Lin KJ, Chen CH, Chen CS, Liu CY, Huang SY et al (2018) Diversity of neurodegenerative pathophysiology in nondemented patients with major depressive disorder: Evidence of cerebral amyloidosis and hippocampal atrophy Brain Behav 8:e01016

    PubMed  Google Scholar 

  • Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A et al (2016) High amyloid-beta deposition related to depressive symptoms in older individuals with normal cognition: a pilot study. Int J Geriatr Psychiatry 31:920–928

    Article  PubMed  Google Scholar 

  • Youn H, Lee ES, Lee S, Suh S, Jeong HG, Eo JS (2018) Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment. J Affect Disord 239:30–36

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Nuclear Medicine Department, HPP—Medicina Molecular, Porto, Portugal

    Tiago S. Vieira

  2. Department of Geriatric Psychiatry, University Medical Center Groningen, University of Groningen, University Center of Psychiatry, Groningen, The Netherlands

    Richard Oude Voshaar

  3. Department of Neurology, Alzheimer Research Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Peter Paul De Deyn

  4. Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium

    Peter Paul De Deyn

  5. Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium

    Peter Paul De Deyn

  6. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Rudi A. J. O. Dierckx & Aren van Waarde

  7. University of Ghent, Ghent, Belgium

    Rudi A. J. O. Dierckx

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Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F. J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Biomedical Sciences of Cells and Systems, University Medical Center Groningen, Groningen, The Netherlands

    Iris E. Sommer

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Vieira, T.S., Voshaar, R.O., De Deyn, P.P., Dierckx, R.A.J.O., van Waarde, A. (2021). SPECT and PET in Late-Life Depression. In: Dierckx, R.A., Otte, A., de Vries, E.F.J., van Waarde, A., Sommer, I.E. (eds) PET and SPECT in Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-57231-0_5

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