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Brain PET Quantification in Neuropsychiatric Research

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PET and SPECT in Psychiatry

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Abstract

Molecular PET neuroimaging in neuropsychiatry focuses on the quantification of brain PET data to assess group differences, short- and long-term effects of treatments or even to measure neurotransmitter levels in psychiatric conditions. In this chapter we introduce the main tracers used in neuropsychiatry, and starting from the basics of dynamic PET imaging, we present different methodologies to quantify PET imaging, including compartmental, graphical and semiquantitative approaches. We also present different approaches to measure changes in neurotransmitter levels induced by pharmacological or behavioural challenge. Finally, we conclude focusing on the potential use of hybrid PET/MRI in neuropsychiatric research.

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Authors and Affiliations

  1. Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium

    Jenny Ceccarini, Koen Van Laere & Michel Koole

  2. Nuclear Medicine and Molecular Imaging, Imagign and Pathology, KU Leuven, Leuven, Belgium

    Jenny Ceccarini, Koen Van Laere & Michel Koole

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  1. Jenny Ceccarini
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  2. Koen Van Laere
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  3. Michel Koole
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Correspondence to Jenny Ceccarini .

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Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F. J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Biomedical Sciences of Cells and Systems, University Medical Center Groningen, Groningen, The Netherlands

    Iris E. Sommer

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Ceccarini, J., Van Laere, K., Koole, M. (2021). Brain PET Quantification in Neuropsychiatric Research. In: Dierckx, R.A., Otte, A., de Vries, E.F.J., van Waarde, A., Sommer, I.E. (eds) PET and SPECT in Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-57231-0_2

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