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Venous Foot and Leg Ulcers

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Stem Cell Therapy for Vascular Diseases

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Abstract

Venous leg ulceration occurs secondary to venous hypertension and dysregulation of the normal wound healing process. These wounds have a significant socioeconomic impact, as they cause substantial patient morbidity and cost the health-care system billions of dollars. Despite a wide array of therapeutic options, current wound care strategies have met with limited success. Stem cells offer the potential to restore the conditions of physiologic wound healing due to their pluripotent capabilities and the release of trophic factors that can modulate key events in the wound healing cascade. Multiple preclinical and clinical trials have demonstrated that stem cell therapy can accelerate wound healing in diabetic wounds, but little is really known about their benefit in venous wounds. Further research is also necessary to better define the ideal stem cell type, source, and method of delivery in order to maximize their therapeutic potential. Larger clinical trials will be necessary to prove their efficacy and safety in all types of wound repair.

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Authors and Affiliations

  1. VA Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, PA, USA

    Edith Tzeng

  2. Division of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Edith Tzeng & Kathy Gonzalez

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  1. Edith Tzeng
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  2. Kathy Gonzalez
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Correspondence to Edith Tzeng .

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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Tzeng, E., Gonzalez, K. (2021). Venous Foot and Leg Ulcers. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_8

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