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Mesenchymal Stem Cell and Hematopoietic Stem Cell Transplantation for Vasculitis

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Stem Cell Therapy for Vascular Diseases

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Abstract

Vasculitis poses a great therapeutic challenge to the treating physician. Steroids remain the mainstay of the treatment and biologics are emerging as popular agents. Similar to other immune-mediated diseases, refractory vasculitis seems to be a suitable candidate for bone marrow and mesenchymal stem cell transplantation. Preliminary data show stem cell-based therapies are feasible and effective in severe, treatment-resistant forms of several types of vasculitis. However, due to the fact that patients are rare, clinical data are sparse. Further prospective studies are needed to confirm these preliminary results. In addition, mostly partial remissions are achieved after stem cell transplantation; thus optimization of the therapeutical regimens is necessary through international cooperation.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China

    Lianming Liao

  2. Department of Vascular Surgery, Xuan Wu Hospital of Capital Medical University, Beijing, China

    Yongquan Gu

Authors
  1. Lianming Liao
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  2. Yongquan Gu
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Editor information

Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Liao, L., Gu, Y. (2021). Mesenchymal Stem Cell and Hematopoietic Stem Cell Transplantation for Vasculitis. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_10

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  • DOI: https://doi.org/10.1007/978-3-030-56954-9_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56953-2

  • Online ISBN: 978-3-030-56954-9

  • eBook Packages: MedicineMedicine (R0)

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