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Gene Therapy in Gliomas

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Principles of Neuro-Oncology

Abstract

Gene therapy is an experimental technique that uses genes to treat or prevent disease. In gliomas different strategies have use: (1) release of suicide genes to produce cytotoxic compounds in the tumor and provoke tumor cell death, (2) oncolytic virotherapy, (3) release of tumor-suppressor genes, (4) immunomodulatory gene therapy, that stimulates an antitumoral immune response,  and (5) the use of synthetic vector particles/nanoparticles to deliver genetic material thereby silencing genes essential to tumorigenesis. Several clinical trails have use gene therapy alone or with other therapies in gliomas, but at the time there is not any gene therapy approve for treatment or prevention in gliomas.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and PhysiologySchool of Pharmacy, and Institute of Nanoscience and Nanotechnology, Universidad de Barcelona, Barcelona, Spain

    Miriam Marlene Medina-Enríquez

  2. Facultad de Medicina, PECEM, Universidad Nacional Autónoma de México, Mexico City, Mexico

    José Alberto Carlos-Escalante

  3. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

    Alma Medrano-Hernández

  4. Subdirection of Basic Reasearch, Instituto Nacional de Cancerología, Mexico City, Mexico

    Talia Wegman-Ostrosky

Authors
  1. Miriam Marlene Medina-Enríquez
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  2. José Alberto Carlos-Escalante
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  3. Alma Medrano-Hernández
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  4. Talia Wegman-Ostrosky
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Aurora Neuroscience Innovation Institute, Milwaukee, WI, USA

    Alejandro Monroy-Sosa

  2. Department of Neurosurgery, Aurora Neuroscience Innovation Institute, Milwaukee, WI, USA

    Srikant S. Chakravarthi

  3. Instituto Nacional de Cancerología, Mexico City, Mexico

    Jaime G. de la Garza-Salazar

  4. Instituto Nacional de Cancerología, Mexico City, Mexico

    Abelardo Meneses Garcia

  5. Neeka Health, LLC, Milwaukee, WI, USA

    Amin B. Kassam

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Medina-Enríquez, M.M., Carlos-Escalante, J.A., Medrano-Hernández, A., Wegman-Ostrosky, T. (2021). Gene Therapy in Gliomas. In: Monroy-Sosa, A., Chakravarthi, S.S., de la Garza-Salazar, J.G., Meneses Garcia, A., Kassam, A.B. (eds) Principles of Neuro-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-54879-7_6

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  • DOI: https://doi.org/10.1007/978-3-030-54879-7_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-54878-0

  • Online ISBN: 978-3-030-54879-7

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