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Albumin-Based Carriers for Systemic Delivery to Tackle Cancer

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Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 13))

Abstract

Proteins have been used to fabricate and design carriers for systemic drug delivery. One of the proteins that shows great potential for the applications in systemic delivery is albumin which is the most abundant plasma protein. This protein has been widely used in nanotechnology-based treatments of many diseases as a promising drug carrier. Taking cancer, an age-associated disease, as an example, the use of albumin nanoparticles as a drug carrier overcomes some of the limitations of chemotherapy such as severe side effects, nonspecific targeting, insolubility in aqueous solutions, short-term retention in bloodstream, and damage to normal cells. There are three main modes for delivering chemotherapeutic drugs with albumin: (1) covalent conjugation of the drug to albumin (prodrugs), (2) non-covalent coupling of the drug to albumin, and (3) encapsulation of the drug into albumin nanoparticles. In this chapter, we will illustrate the use of albumin-based carriers in anti-aging medicine, particularly in cancer treatments. In particular, we will present an overview of studies examining the anticancer effects of natural and synthetic drugs loaded to albumin (in all three modes) and related challenges.

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Author information

Authors and Affiliations

  1. Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

    Hossein Rahimi

  2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Marziyeh Salehiabar & Soodabeh Davaran

  3. Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Hossein Danafar & Hamed Nosrati

Authors
  1. Hossein Rahimi
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  2. Marziyeh Salehiabar
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  3. Soodabeh Davaran
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  4. Hossein Danafar
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  5. Hamed Nosrati
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Corresponding authors

Correspondence to Hossein Danafar or Hamed Nosrati .

Editor information

Editors and Affiliations

  1. School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China

    Wing-Fu Lai

Glossary

Albumin

is the most abundant plasma protein that has many important roles, such as transporting fatty acids, thyroid hormones, bile acids, etc. Albumin nanoparticles have been used as drug carriers in the treatment of many diseases such as cancers.

Alkylating agent

an anticancer compound that prevents the transcription of DNA molecules into RNAs and eventually the protein synthesis by linking the alkyl group to the guanine bases of DNA molecules.

Apoptosis

is the programmed cell death that plays a critical role in the elimination of unnecessary cells such as damaged cells and virus-infected cells.

Curcumin

is the main component of turmeric. Curcumin has many properties such as antioxidant, anticancer, anti-inflammation, etc.

Desolvation

a method that can be used to prepare albumin nanoparticles by adding a solvent (such as ethanol or acetone) dropwise to an aqueous solution of albumin proteins under a magnetic stirrer in order to dehydrate the proteins.

Nanocomposite

a compound consisting of two or more materials of which at least one is nanosized.

Radioprotector

agents that protect healthy cells from radiation when tumor cells are irradiated.

Radiosensitizer

agents that increase the sensitivity of tumor cells to radiotherapy.

Sonoporation

a biophysical method for the formation of transient pores in plasma membranes which facilitates specific targeting drug delivery.

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Rahimi, H., Salehiabar, M., Davaran, S., Danafar, H., Nosrati, H. (2020). Albumin-Based Carriers for Systemic Delivery to Tackle Cancer. In: Lai, WF. (eds) Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Healthy Ageing and Longevity, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-54490-4_9

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