Skip to main content

Abstract

The histological appearance of the fetal kidney is significantly different from that of the adult kidney, mostly because it continues to develop almost until the end of gestation, when the formation of nephrons (nephrogenesis) comes to an end. A lack of familiarity with these differences may lead to mistakenly considering normal findings as pathologic ones, or to overlooking abnormalities of renal development, such as impaired nephrogenesis with a reduced number of nephrons (as seen in intrauterine growth restriction) or abnormal tubular differentiation (as seen in renal tubular dysgenesis). The aim of this chapter is to review the dramatic changes in renal development in the fetal and neonatal period and highlight the important differences at various gestational ages.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. O’Rahilly R, Muecke EC. The timing and sequence of events in the development of the human urinary system during the embryonic period proper. Z Anat Entwicklungsgesch. 1972;138:99–109.

    Article  Google Scholar 

  2. Potter EL. Normal and abnormal development of the kidney. Chicago: Year Book Medical; 1972.

    Google Scholar 

  3. O’Rahilly R, Müller F. Developmental stages in human embryos. Washington, DC: Carnegie Institution Of Washington; 1987.

    Google Scholar 

  4. Sykes D. The morphology of renal lobulations and calices, and their relationship to partial nephrectomy. Br J Surg. 1964;51:294–304.

    Article  CAS  Google Scholar 

  5. Dorovini-Zis K, Dolman CL. Gestational development of brain. Arch Pathol Lab Med. 1977;101:192–5.

    CAS  PubMed  Google Scholar 

  6. Hinchliffe SA, Sargent PH, Chan YF, van Velzen D, Howard CV, Hutton JL, Rushton DI. “Medullary ray glomerular counting” as a method of assessment of human nephrogenesis. Pathol Res Pract. 1992;188:775–82.

    Article  CAS  Google Scholar 

  7. Clapp WL, Croker BP. Kidney. In: Mills SE, editor. Histology for pathologists. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2012. p. 891–970.

    Google Scholar 

  8. Souster LP, Emery JL. The sizes of renal glomeruli in fetuses and infants. J Anat. 1980;130:595–602.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Emery JL, Macdonald MS. Involuting and scarred glomeruli in the kidneys of infants. Am J Pathol. 1960;36:713–23.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Yosypiv IV. A new role for the renin-angiotensin system in the development of the ureteric bud and renal collecting system. Keio J Med. 2008;57:184–9.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eduardo D. Ruchelli .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ruchelli, E.D., Huff, D.S. (2019). Kidney. In: Ernst, L., Ruchelli, E., Carreon, C., Huff, D. (eds) Color Atlas of Human Fetal and Neonatal Histology. Springer, Cham. https://doi.org/10.1007/978-3-030-11425-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-11425-1_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11424-4

  • Online ISBN: 978-3-030-11425-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics