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Application of Wild Macrofungi as Anticancer Therapeutics

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Biology of Macrofungi

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Man consume mushroom because it is delicious. In the East, mushroom as medicine is not uncommon. Following encouraging outcome from clinical trials, several properties from edible and wild mushroom species have been recognised and registered as anticancer therapeutics. The drive to examine existing and wild mushrooms growing in each respective country for anticancer properties sees the compilation of new and unknown medicinal mushrooms research being shared for further assessment. The accumulated evidence of mushrooms possessing an anticancer property is attributed to all the extensive studies on cell lines, animal and human trials, validating the health, safety and quality of life after treatment. The move treads towards finding selective cytotoxicity mushroom properties which would only target cancerous cells and not harm normal healthy cells. The wealth of knowledge we have garnered for the last 20 years on how all macro fungi; be it edible, non-edible, poison or recreation mushrooms conceal in them the properties we could use to suppress the statistics of death and suffering due to cancer. Inevitably, the way forward next is to explore the potential of all wild and less commonly known mushroom resources and push these candidates down the pipeline for the next 20 years of further anticancer research, if not, potentials as food and delicacies.

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Abbreviations

AHCC:

Active Hexose Correlated Compound

CNL:

Clitocybe nebularis lectin

COX2:

Cyclooxygenase-2

CR:

Complement Receptors

FIP:

Fungal Immunomodulatory Protein

GLU:

Ganoderma lucidum

IFN:

Interferon

IL:

Interleukin

NK:

Natural Killer

PSK:

Polysaccharide Krestin

PSP:

Polysaccharopeptide

RNA:

Ribonucleic acid

ROS :

Reactive Oxygen Species

SPG:

Schizophyllan

TCM:

Traditional Chinese Medicine

TK:

Traditional Knowledge

TMM:

Tiger Milk Mushroom

TNF:

Tumour Necrosis Factor

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Authors and Affiliations

  1. Medicinal Mushroom Research Group (MMRG), Department of Molecular Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Peter Chiew Hing Cheong & Shin Yee Fung

  2. Ligno Research Foundation, Selangor, Malaysia

    Chon Seng Tan

  3. Centre for Natural Products Research and Drug Discovery (CENAR), University of Malaya, Kuala Lumpur, Malaysia

    Shin Yee Fung

  4. University of Malaya Centre for Proteomics Research (UMCPR), University of Malaya, Kuala Lumpur, Malaysia

    Shin Yee Fung

Authors
  1. Peter Chiew Hing Cheong
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  2. Chon Seng Tan
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  3. Shin Yee Fung
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Corresponding author

Correspondence to Shin Yee Fung .

Editor information

Editors and Affiliations

  1. Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India

    Bhim Pratap Singh

  2. Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India

    Lallawmsanga

  3. Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India

    Ajit Kumar Passari

Cell Lines

Cell Lines

A431

Human epidermoid carcinoma

A549

Human lung adenocarcinoma

B16

Mouse melanoma cell line

BGC-823

Human gastric carcinoma cells

COS-7

African green monkey kidney fibroblast-like cell line

ES-2

Ovarian carcinoma

IGROV-1

Human ovarian carcinoma

HCT116

Human colon carcinoma cell line

HeLa

Human cervical cancer cell line

HepG2

Human hepatocellular carcinoma cell line

HL-60

Human leukaemia acute promyelocytic human leukaemia

HT29

Human colon colorectal adenocarcinoma cell line

Huh-7

Human hepatic cell model

L-1210

Murine lymphocytic leukaemia cell line

LLC

Lewis lung carcinoma

LS174

Colon carcinoma

M1

Leukaemia cell line

MCF-7

Human mammary adenocarcinoma cell line

MDA-MB-231

Human breast adenocarcinoma

MGC80–3

Human gastric adenocarcinoma cell line

MKN45

Gastric carcinoma

Mo-T

Human leukaemia T-cell

NCI-N87

Human gastric cancer cells

PC-3

Human prostate grade IV, adenocarcinoma

RP9

Avian cancer cell line

S-180

Sarcoma Cancer associated with hypercalcemia

SGC-7901

Gastric carcinoma cell line

SKOV-3

Human ovarian adenocarcinoma

SW480

Human colorectal cancer, epithelial

U937

Human lung lymphoblast

Vero

African green monkey kidney cell line

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Cheong, P.C.H., Tan, C.S., Fung, S.Y. (2018). Application of Wild Macrofungi as Anticancer Therapeutics. In: Singh, B., Lallawmsanga, Passari, A. (eds) Biology of Macrofungi. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-02622-6_12

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