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TREM-1 et suPAR

  • Chapter
Les biomarqueurs en médecine d’urgence

Part of the book series: Références en médecine d’urgence. Collection de la SFMU ((REFERMED))

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Résumé

La reconnaissance précoce des patients septiques les plus à risque permet une prise en charge adaptée dans les plus brefs délais, seule garante d’une amélioration du pronostic, tandis que la reconnaissance des malades les moins sévères permet de limiter les temps de séjour aux urgences, et de prioriser les ressources. Ce chapitre exposera deux biomarqueurs de l’inflammation récemment développés, sTREM-1 et suPAR moins connus que les marqueurs habituels (CRP et la procalcitonine, PCT).

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Références

  1. Ford JW, McVicar DW (2009) TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 21: 38–46

    Article  PubMed  CAS  Google Scholar 

  2. Colonna M, Facchetti F (2003) TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J Infect Dis 187Suppl 2:S397–401

    Article  PubMed  CAS  Google Scholar 

  3. Haselmayer P, Grosse-Hovest L, von Landenberg P, et al. (2007) TREM-1 ligand expression on platelets enhances neutrophil activation. Blood 110: 1029–1035

    Article  PubMed  CAS  Google Scholar 

  4. Bouchon A, Facchetti F, Weigand MA, Colonna M (2001) TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410: 1103–1107

    Article  PubMed  CAS  Google Scholar 

  5. Gomez-Pina V, Soares-Schanoski A, Rodriguez-Rojas A, et al. (2007) Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol 179: 4065–4073

    PubMed  CAS  Google Scholar 

  6. Wong-Baeza I, Gonzalez-Roldan N, Ferat-Osorio E, et al. (2006) Triggering receptor expressed on myeloid cells (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients. Clin Exp Immunol 145: 448–455

    Article  PubMed  CAS  Google Scholar 

  7. Gibot S, Cravoisy A, Levy B, et al. (2004) Soluble triggering receptor expressed on myeioid cells and the diagnosis of pneumonia. N Engl J Med 350:451–458

    Article  PubMed  CAS  Google Scholar 

  8. Gibot S, Kolopp-Sarda MN, Bene MC, et al. (2004) Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med 141: 9–15

    PubMed  CAS  Google Scholar 

  9. Latour-Perez J, Alcala-Lopez A, Garcia-Garcia MA, et al. (2010) Diagnostic accuracy of sTREM-l to identify infection in critically ill patients with systemic inflammatory response syndrome. Clin Biochem 43: 720–724

    Article  PubMed  Google Scholar 

  10. Barati M, Bashar FR, Shahrami R, et al. (2010) Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis. J Crit Care 25: 362 e1-6

    Article  PubMed  Google Scholar 

  11. Kofoed K, Andersen O, Kronborg G, et al. (2007) Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care 11: R38

    Article  PubMed  Google Scholar 

  12. Chen HL, Hung CH, Tseng HI, Yang RC (2008) Soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic marker of serious bacterial infection in febrile infants less than three months of age. Jpn J Infect Dis 61: 31–35

    PubMed  CAS  Google Scholar 

  13. Sarafidis K, Soubasi-Griva V, Piretzi K, et al. (2010) Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-l in infected neonates. Intensive Care Med 36: 864–868

    Article  PubMed  CAS  Google Scholar 

  14. Miedema KG, de Bont ES, Elferink RF, et al. (2011) The diagnostic value of CRP, IL-8, PCT, and sTREM-1 in the detection of bacterial infections in pédiatric oncology patients with febrile neutropenia. Support Care Cancer 19: 1593–600

    Article  PubMed  Google Scholar 

  15. Gamez-Diaz LY, Enriquez LE, Matute JD, et al. (2011) Diagnostic accuracy of HMGB-1, sTREM-1, and CD64 as markers of sepsis in patients recently admitted to the emergency department. Acad Emerg Med 18: 807–815.

    Article  PubMed  Google Scholar 

  16. Muller B, Gencay MM, Gibot S, et al. (2007) Circulating levels of soluble triggering receptor expressed on myeloid cells (sTREM)-l in community-acquired pneumonia. Crit Care Med 35: 990–991

    Article  PubMed  Google Scholar 

  17. Phua J, Koay ES, Zhang D, et al. (2006) Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J 28: 695–702

    Article  PubMed  CAS  Google Scholar 

  18. Summah H, Tao LL, Zhu YG, et al. (2011) Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. BMC Infect Dis 11: 280

    Article  PubMed  Google Scholar 

  19. Barraud D, Gibot S (2011) Triggering receptor expressed on myeloid cell 1. Crit Care Clin 27: 265–279

    Article  PubMed  CAS  Google Scholar 

  20. Jiyong J, Tiancha H, Wei C, Huahao S (2009) Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 35: 587–595

    Article  PubMed  Google Scholar 

  21. Gibot S, Massin F, Le Renard P, et al. (2005) Surface and soluble triggering receptor expressed on myeloid cells-1: expression patterns in murine sepsis. Crit Care Med 33: 1787–1793

    Article  PubMed  CAS  Google Scholar 

  22. Giamarellos-Bourboulis EJ, Zakynthinos S, Baziaka F, et al. (2006) Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis. Intensive Care Med 32: 237–2343

    Article  PubMed  CAS  Google Scholar 

  23. Wu CL, Lu YT, Kung YC, et al. (2011) Prognostic value of dynamic soluble triggering receptor expressed on myeloid cells in bronchoalveolar lavage fluid of patients with ventilator-associated pneumonia. Respirology 16: 487–494

    Article  PubMed  Google Scholar 

  24. Tejera A, Santolaria F, Diez ML, et al. (2007) Prognosis of community acquired pneumonia (CAP): value of triggering receptor expressed on myeloid cells-1 (TREM-1) and other mediators of the inflammatory response. Cytokine 38: 117–123

    Article  PubMed  CAS  Google Scholar 

  25. Adib-Conquy M, Monchi M, Goulenok C, et al. (2007) Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection. Shock 28: 406–410

    Article  PubMed  CAS  Google Scholar 

  26. Phua J, Koay ES, Zhang D, Lee KH (2008) How well do serum sTREM-1 measurements prognosticate in septic shock? Anaesth Intensive Care 36: 654–658

    PubMed  CAS  Google Scholar 

  27. Blasi F, Carmeliet P (2002) uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 3: 932–943

    Article  PubMed  CAS  Google Scholar 

  28. Estreicher A, Muhlhauser J, Carpentier JL, et al. (1990) The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol 111: 783–792

    Article  PubMed  CAS  Google Scholar 

  29. Thuno M, Macho B, Eugen-Olsen J (2009) suPAR: the molecular crystal ball. Dis Markers. 27: 157–172

    PubMed  Google Scholar 

  30. Fazioli F, Resnati M, Sidenius N, et al. (1997) A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity. EMBO J 16:7279–7286

    Article  PubMed  CAS  Google Scholar 

  31. Koch A, Voigt S, Kruschinski C, et al. (2011) Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit Care 15: R63

    Article  PubMed  Google Scholar 

  32. Huttunen R, Syrjanen J, Vuento R, et al. (2011) Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study. J Intern Med 270: 32–40

    Article  PubMed  CAS  Google Scholar 

  33. Molkanen T, Ruotsalainen E, Thorball CW, Jarvinen A (2011) Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Di 30: 1417–1424

    Article  CAS  Google Scholar 

  34. Sawa A, Raftogiannis M, Baziaka F, et al. (2011) Soluble urokinase plasminogen activator receptor (suPAR) for assessment of disease severity in ventilator-associated pneumonia and sepsis. J Infect 63: 344–350

    Article  Google Scholar 

  35. El Solh AA, Akinnusi ME, Peter M, et al. (2008) Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes. Intensive Care Med 34: 1012–1019

    Article  Google Scholar 

  36. Huh JW, Lim CM, Koh Y, et al. (2008) Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates. Crit Care 12: R6

    Article  PubMed  Google Scholar 

  37. Horonenko G, Hoyt JC, Robbins RA, et al. (2007) Soluble triggering receptor expressed on myeloid cell-1 is increased in patients with ventilator-associated pneumonia: a preliminary report. Chest 132: 58–63

    Article  PubMed  CAS  Google Scholar 

  38. Anand NJ, Zuick S, Klesney-Tait J, Kollef MH (2009) Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest 135: 641–647

    Article  PubMed  Google Scholar 

  39. Oudhuis GJ, Beuving J, Bergmans D, et al. (2009) Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia. Intensive Care Med 35: 1265–1270

    Article  PubMed  CAS  Google Scholar 

  40. Determann RM, Millo JL, Gibot S, et al. (2005) Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med 31: 1495–1500

    Article  PubMed  Google Scholar 

  41. Chan MC, Chang KM, Chao WC, et al. (2007) Evaluation of a new inflammatory molecule (triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion. Respirology 12: 333–338

    Article  PubMed  Google Scholar 

  42. Huang LY, Shi HZ, Liang QL, et al. (2008) Expression of soluble triggering receptor expression on myeloid cells-1 in pleural effusion. Chin Med J (Engl) 121: 1656–1661

    Google Scholar 

  43. Bishara J, Goldberg E, Ashkenazi S, et al. (2009) Soluble triggering receptor expressed on myeloid cells-1 for diagnosing empyema. Ann Thorac Surg 87: 251–254

    Article  PubMed  Google Scholar 

  44. Determann RM, Achouiti AA, El Solh AA, et al. (2010) Infectious pleural effusions can be identified by sTREM-1 levels. Respir Med 104: 310–315

    Article  PubMed  CAS  Google Scholar 

  45. Kim JH, Park EI, H. KW (2007) Soluble triggering receptor expressed on myeloid cells-1: role in diagnosis of pleural effusions. Tuberc Respir Dis 62: 290–298

    Article  Google Scholar 

  46. Determann RM, Weisfeit M, de Gans J, et al. (2006) Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med 32: 1243–1247

    Article  PubMed  CAS  Google Scholar 

  47. Bishara J, Hadari N, Shalita-Chesner M, et al. (2007) Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis 26: 647–650

    Article  PubMed  CAS  Google Scholar 

  48. Determann RM, Schultz MJ, Geerlings SE (2007) Soluble triggering receptor expressed on myeloid cells-1 is not a sufficient biological marker for infection of the urinary tract. J Infect 54: e249–250

    Article  PubMed  Google Scholar 

  49. Determann RM, van Till JW, van Ruler O, et al. (2009) sTREM-1 is a potential useful biomarker for exclusion of ongoing infection in patients with secondary peritonitis. Cytokine 46: 36–42

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Service de réanimation médicale, Hopital Central, CHU Nancy, Avenue de Lattre-de-Tassigny, 54000, Nancy

    D. Barraud & S. Gibot

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  1. D. Barraud
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  2. S. Gibot
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Editors and Affiliations

  1. Département de médecine d’urgence, Centre hospitalier Princesse Grace, 1, avenue Pasteur, BP 489, MC-98012, Monaco

    Yann-Érick Claessens

  2. Hôpital Tenon Service d’accueil des urgences, UPMC-Paris 6, 4, rue de la Chine, 75020, Paris, France

    Patrick Ray

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Barraud, D., Gibot, S. (2012). TREM-1 et suPAR. In: Claessens, YÉ., Ray, P. (eds) Les biomarqueurs en médecine d’urgence. Références en médecine d’urgence. Collection de la SFMU. Springer, Paris. https://doi.org/10.1007/978-2-8178-0297-8_18

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  • DOI: https://doi.org/10.1007/978-2-8178-0297-8_18

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0296-1

  • Online ISBN: 978-2-8178-0297-8

  • eBook Packages: MedicineMedicine (R0)

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