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Growth Factors for Promoting Wound Healing

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Biomaterials for Surgical Operation

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Abstract

The wound-healing process requires many types of growth factors, and exogenous delivery of appropriate growth factors to the injured site leads to accelerated healing. To deliver such growth factors, carriers which are generally made of bioabsorbable polymers are employed. However, only a few release systems, including a combination of bone morphogenetic protein (BMP) and a collagen sponge, are commercially available for the delivery of growth factors. However, this collagen carrier needs a large amount of BMP due to the low efficacy of the carrier. Studies on more effective carriers for the growth factors are ongoing. Recently, technologies to concentrate the patient’s own platelets which contain a large amount of the growth factors have been developed. Since the growth factors are completely autologous, it should be safe and cost effective. This chapter offers a review of recent studies on growth factor–carrier systems, as well as emerging technologies for platelet-rich plasma (PRP). Importance of carriers is emphasized to effectively deliver growth factors.

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  1. Graduate School Department of Medical Engineering, Nara Medical University, Shijo-cho 840, Kashihara-shi, 634-8521, Nara, Japan

    Shuko Suzuki & Yoshito Ikada

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Suzuki, S., Ikada, Y. (2012). Growth Factors for Promoting Wound Healing. In: Biomaterials for Surgical Operation. Humana Press. https://doi.org/10.1007/978-1-61779-570-1_7

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