Abstract
Gestational choriocarcinoma is the most aggressive form of trophoblastic disease with tumor cells morphologically recapitulating the trophoblast of the developing placenta at its previllous stage. The tumor has a high propensity for hematogenous spread, and in fact, one of the most malignant tumors in human if untreated. Being a disease of long historical recognition (see Chap. 1), various names were used in the past including sarcoma uteri deciduocellulare as a malignant tumor derived from the decidua of pregnancy (Int J Gynecol Pathol 19(3):284–292, 2000), “deciduoma malignum” or “chorio-deciduo-cellular sarcoma,” “sarcoma of the chorial villi,” and “chorioepithelioma” (Int J Gynecol Pathol 19(3):284–292, 2000; Int J Gynecol Pathol 18(3):281–287, 1999). The term “choriocarcinoma” was eventually introduced by Ewing (J Hist Med Allied Sci 16:49–73, 1961; Surg Gynecol Obstet 10:26, 1910). The inception of chemotherapy management in late 1950s marked the beginning of the era of dramatic decrease in mortality of patients with gestational choriocarcinoma (Proc Soc Exp Biol Med 93:5, 1956). Once an invariably fatal malignancy, the tumor can be treated with over 90% survival or cure rate by methotrexate-based chemotherapy (Proc Soc Exp Biol Med 93:5, 1956; Am J Obstet Gynecol 82:631–640, 1961).
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Hui, P. (2012). Gestational Choriocarcinoma. In: Hui, P. (eds) Gestational Trophoblastic Disease. Current Clinical Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-61779-394-3_8
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