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Gestational trophoblastic neoplasia: an update

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Abstract

Gestational trophoblastic neoplasia (GTN) includes invasive mole, choriocarcinoma, and placental site trophoblastic tumors. The overall cure rate in treating these tumors currently exceeds 90%. Thorough evaluation and staging allow selection of appropriate therapy that maximizes chances for cure while minimizing toxicity. Nonmetastatic (stage I) and low-risk metastatic (stages II and III, World Health Organization [WHO] score < 7) GTN can be treated with single-agent chemotherapy, resulting in a survival rate approaching 100%. High-risk metastatic GTN (stage IV, WHO score ≥ 7) requires initial multiagent chemotherapy with or without adjuvant radiation and surgery to achieve a survival rate of 80% to 90%.

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Authors and Affiliations

  1. John I. Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, 250 East Superior Street, Suite 05-2168, Chicago, IL, 60611, USA

    John R. Lurain

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  1. Jacqueline M. Morgan
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  2. John R. Lurain
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Correspondence to John R. Lurain.

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Morgan, J.M., Lurain, J.R. Gestational trophoblastic neoplasia: an update. Curr Oncol Rep 10, 497–504 (2008). https://doi.org/10.1007/s11912-008-0075-y

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