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Progenitor Cell Tissue Engineering

Scaffold Design and Fabrication

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Progenitor Cell Therapy for Neurological Injury

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

A critical aspect of cell and tissue engineering is the design of non-cellular constructs that closely interact with cells to provide the necessary conditions for intended function. Properties such as surface chemistry, mechanical strength, porosity, and rates of degradation are important elements of a cellular support system and can deeply influence the fate of progenitor cells. To achieve the goal of successful implantation and proliferation of cells in a particular region, various biomaterials and fabrication processes have been explored. Lately, techniques with origins outside the field of biology or medicine have been used to create highly controlled morphologies. This chapter will review the fundamentals of scaffold design as it relates to brain-based therapies and give some examples of fabrication techniques.

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Abbreviations

3DP:

Three-dimensional printing

BDNF:

Brain-derived neurotrophic factor

CAD:

Computer-aided design

CNS:

Central nervous system

DCM:

Dichloromethane

ECM:

Extracellular matrix

ESC:

Embryonic stem cell

FDM:

Fused deposition modeling

GMP:

Good manufacturing practices

HFIP:

Hexafluoro-2-propanol

MSC:

Mesenchymal stromal cell

NGF:

Nerve growth factor

P(LLA-CL):

Poly(l-lactic acid-co-caprolactone)

PCL:

Poly(caprolactone)

PGA:

Poly(glycolic acid)

PLGA:

Poly(lactic-co-glycolic acid)

PLLA:

Poly(l-lactic acid)

PNS:

Peripheral nervous system

PVDF:

Poly(vinylidene fluoride)

RGD:

Arginine-glycine-aspartic acid

RP:

Rapid prototyping

SLA:

Stereolithography

SLS:

Selective laser sintering

THF:

Tetrahydrofuran

TIPS:

Thermally induced phase separation

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  1. Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA

    Kevin R. Aroom

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  2. Brijesh S. Gill
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Correspondence to Kevin R. Aroom .

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  1. Medical School at Houston, Div. Pediatric Surgery, University Texas, Fannin Street 6431, Houston, 77030, Texas, USA

    S. Charles Jr.

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Aroom, K.R., Gill, B.S. (2011). Progenitor Cell Tissue Engineering. In: Charles, S. (eds) Progenitor Cell Therapy for Neurological Injury. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-965-9_2

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