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PKCδ as a Target for Chemotherapeutic Drugs

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Protein Kinase C in Cancer Signaling and Therapy

Part of the book series: Current Cancer Research ((CUCR))

Abstract

PKCd, a member of the novel PKC family, has been widely implicated as mediator of apoptosis in response to phorbol esters and chemotherapeutic agents, and it is differentially expressed in various human cancer types. A characteristic of PKCd is that it is regulated by tyrosine phosphorylation, and in some cases this post-translational modification seems to be essential for the response to stimuli. PKCd may be an attractive target for cancer therapeutics.

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  1. William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA

    Chaya Brodie & Stephanie L. Lomonaco

  2. Mina and Everard Goodman Faculty of Life-Sciences, Bar-Ilan University, Ramat-Gan, Israel

    Chaya Brodie

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    Marcelo G. Kazanietz

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Brodie, C., Lomonaco, S.L. (2010). PKCδ as a Target for Chemotherapeutic Drugs. In: Kazanietz, M. (eds) Protein Kinase C in Cancer Signaling and Therapy. Current Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-543-9_22

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