Skip to main content
SpringerLink
Log in

The Relationship of Nutrition and Pressure Ulcers

  • Chapter
  • First Online:
Handbook of Clinical Nutrition and Aging

Part of the book series: Nutrition and Health ((NH))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 199.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Young ME. Malnutrition and wound healing. Heart Lung 1988;17:60–7.

    PubMed  CAS  Google Scholar 

  2. Casey J, Flinn WR, Yao JST, et al. Correlation of immune and nutritional status with wound complications in patients undergoing vascular operations. Surgery 1983;93:822–7.

    PubMed  CAS  Google Scholar 

  3. Detsky AS, Baker JP, O'Rourke K, et al. Predicting nutrition-associated complications for patients undergoing gastrointestinal surgery. JPEN 1987;11:440–6.

    Article  CAS  Google Scholar 

  4. Covinsky KE, Covinsky MH, Palmer RM, Sehgal AR. Serum albumin concentration and clinical assessments of nutritional status in hospitalized older people: Different sides of different coins? J Am Geriatr Soc 2002;50:631–7.

    Article  PubMed  Google Scholar 

  5. Takeda T, Koyama T, Izawa Y, et al. Effects of malnutrition on development of experimental pressure sores. J Dermatol 1992;19:602–9.

    PubMed  CAS  Google Scholar 

  6. Thomas DR, Goode PS, Tarquine PH, Allman R. Hospital acquired pressure ulcers and risk of Death. J Amer Geriatr Soc 1996;44:1435–40.

    CAS  Google Scholar 

  7. Pinchcofsky-Devin GD, Kaminski MV Jr. Correlation of pressure sores and nutritional status. J Am Geriatr Soc 1986;34:435–40.

    PubMed  CAS  Google Scholar 

  8. Bergstrom N, Braden B: A prospective study of pressure sore risk among institutionalized elderly. J Am Geriatr Soc 1992;40:747–58.

    PubMed  CAS  Google Scholar 

  9. Berlowitz DR, Wilking SV. Risk factors for pressure sores: a comparison of cross- sectional and cohort-derived data. J Am Geriatr Soc 1989;37:1043–50.

    PubMed  CAS  Google Scholar 

  10. Thomas DR. The role of nutrition in prevention and healing of pressure ulcers. Clin Geriatr Med 1997;13:497–511.

    PubMed  CAS  Google Scholar 

  11. Thomas DR. Improving the outcome of pressure ulcers with nutritional intervention: A review of the evidence. Nutrition 2001;17:121–5.

    Article  PubMed  CAS  Google Scholar 

  12. Bourdel-Marchasson I, Barateau M, Sourgen C, et al. Prospective audits of quality of PEM recognition and nutritional support in critically ill elderly patients. Clin Nutr 1999;18:233–40.

    Article  PubMed  CAS  Google Scholar 

  13. Bourdel-Marchasson I, Barateau M, Rondeau V, Dequae-Merchadou L, Salles-Montaudon N, Emeriau JP, Manciet G, Dartigues JF. A multi-center trial of the effects of oral nutritional supplementation in critically ill older inpatients. GAGE Group. Groupe Aquitain Geriatrique d'Evaluation. Nutrition 2000;16:1–5.

    Article  PubMed  CAS  Google Scholar 

  14. Delmi M, Rapin CH, Bengoa JM, Delmas PD, Vasey H, Bonjour JP. Dietary supplementation in elderly patients with fractured neck of the femur. Lancet 1990;335(8696):1013–6.

    Article  PubMed  CAS  Google Scholar 

  15. Houwing RH, Rozendaal M, Wouters-Wesseling W, Beulens JW, Buskens E, Haalboom JR. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Nutrition 2003;22(4):401–5.

    CAS  Google Scholar 

  16. Rebecca J. Stratton, Anna-Christina Ek, Meike Engfer, Zena Moore, Paul Rigby, Robert Wolfe, Marinos Elia. Enteral nutritional support in prevention and treatment of pressure ulcers: A systematic review and meta-analysis. Ageing Res Rev 2005;4:422–50.

    Article  Google Scholar 

  17. Hartgrink HH, Wille J, Konig P, et al. Pressure sores and tube feeding in patients with a fracture of the hip: a randomized clinical trial. Clin Nutr 1998;6:287–92.

    Article  Google Scholar 

  18. Henderson CT, Trumbore LS, Mobarhan S, et al. Prolonged tube feeding in long-term care: Nutritional status and clinical outcomes. J Am College Clin Nutr 1992;11:309.

    CAS  Google Scholar 

  19. Mitchell SL, Kiely DK, Lipsitz LA. The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment. Arch Intern Med 1997;157:327–32

    Article  PubMed  CAS  Google Scholar 

  20. Albina JE. Nutrition and wound healing. JPEN 1994;18:367–76.

    Article  CAS  Google Scholar 

  21. Thomas DR. Issues and dilemmas in managing pressure ulcers. J Gerontol Med Sci 2001;56:M238–340.

    Google Scholar 

  22. Choban PS, Burge JC, Flanobaum L. Nutrition support of obese hospitalized patients. Nutr Clin Pract 1997;12:149–54.

    Article  Google Scholar 

  23. Ireton-Jones CS. Evaluation of energy expenditures in obese patients. Nutr Clin Pract 1989;4:127–9.

    Article  PubMed  CAS  Google Scholar 

  24. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Protein and Amino Acids (Macronutrients). In: Energy: The National Academies Press, 2002:93–206.

    Google Scholar 

  25. Chernoff RS, Milton KY, Lipschitz DA. The effect of very high-protein liquid formula (Replete) on decubitus ulcer healing in long-term tube-fed institutionalized patients. Investigators Final Report 1990. J Am Diet Assoc 1990;90(9):A–130.

    Google Scholar 

  26. Breslow RA, Hallfrisch J, Guy DG, et al. The importance of dietary protein in healing pressure ulcers. J Am Geriatr Soc 1993;41:357–62.

    PubMed  CAS  Google Scholar 

  27. Gersovitz M, Motil K, Munro HN, Scrimshaw. Human protein requirements: Assessment of the adequacy of the current Recommended Dietary Allowance for dietary protein in elderly men and women. Am J Clin Nutr 1982;35:6–14.

    Google Scholar 

  28. Long CL, Nelson KM, Akin JM Jr, Geiger JW, Merrick HW, Blakemore WZ. A physiologic bases for the provision of fuel mixtures in normal and stressed patients. J Trauma 1990;30:1077–86.

    Article  PubMed  CAS  Google Scholar 

  29. McCauley\ R, Platell C, Hall J, McCulloch R. Effects of glutamine on colonic strength anastomosis in the rat. J Parenter Enter Nutr 1991;116:821.

    Google Scholar 

  30. Barbul A, Lazarous S, Efron DT, et al. Arginine enhances wound healing in humans. Surgery 1990;108:331–7.

    PubMed  CAS  Google Scholar 

  31. Kirk SJ, Regan MC, Holt D, et al. Arginine stimulates wound healing and immune function in aged humans. Surgery 1993;114:155.

    PubMed  CAS  Google Scholar 

  32. Langkamp-Henken B. Herrlinger-Garcia KA. Stechmiller JK. Nickerson-Troy JA. Lewis B. Moffatt L. Arginine supplementation is well tolerated but does not enhance mitogen-induced lymphocyte proliferation in elderly nursing home residents with pressure ulcers. J Parenter Enter Nutr 2000;24(5):280–7.

    Article  CAS  Google Scholar 

  33. McCauley C, Platell C, Hall J, McCullock R. Influence of branched chain amino acid solutions on wound healing. Aust NZ J Surg 1990;60:471.

    Article  CAS  Google Scholar 

  34. Crandon JH, Lind CC, Dill DB. Experimental human scurvy. N Engl J Med 1940;223:353.

    Article  CAS  Google Scholar 

  35. Levenson SM, Upjohn HL, Preston JA, et al. Effect of thermal burns on wound healing. Ann Surg 1957;146:357–68.

    PubMed  CAS  Google Scholar 

  36. Rackett SC, Rothe MJ, Grant-Kels JM. Diet and dermatology. The role of dietary manipulation in the prevention and treatment of cutaneous disorders. J Am Acad Dermatol 1993;29:447–61.

    Article  PubMed  CAS  Google Scholar 

  37. Vilter RW. Nutritional aspects of ascorbic acid: Uses and abuses. West J Med 1980;133:485.

    PubMed  CAS  Google Scholar 

  38. ter Riet G, Kessels AG, Knipschild PG. Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. J Clin Epidemiol 1995;48:1453–60.

    Article  PubMed  Google Scholar 

  39. Taylor TV, Rimmer S, Day B, Butcher J, Dymock IW. Ascorbic acid supplementation in the treatment of pressure sores. Lancet 1974;2:544–6.

    Article  PubMed  CAS  Google Scholar 

  40. Hunt TK. Vitamin A and wound healing. J AM Acad Dermatol 1986;15:817–21.

    Article  PubMed  CAS  Google Scholar 

  41. Ehrlich HP, Hunt TK. Effects of cortisone and vitamin A on wound healing. Ann Surg 1968;167:324.

    Article  PubMed  CAS  Google Scholar 

  42. Waldorf H, Fewkes J. Wound healing. Adv Dermatol 1995;10:77–96.

    PubMed  CAS  Google Scholar 

  43. Pories WJ, Henzel WH, Rob CG, et al. Acceleration of healing with zinc sulfate. Ann Surg 1967;165:423.

    Google Scholar 

  44. Hallbrook T, Lanner E. Serum zinc and healing of leg ulcers. Lancet 1972;2:780.

    Article  Google Scholar 

  45. Sandstead SH, Henrikson LK, Greger JL, et al. Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing. Am J Clin Nutr 1982;36(Supp):1046.

    PubMed  CAS  Google Scholar 

  46. Goode HF, Burns E, Walker BE. Vitamin C depletion and pressure ulcers in elderly patients with femoral neck fracture. Brit Med J 1992:305:925–7.

    Article  PubMed  CAS  Google Scholar 

  47. Norris JR, Reynolds RE. The effect of oral zinc sulfate therapy on decubitus ulcers. JAGS 1971;19:793.

    Google Scholar 

  48. Goode P, Allman R. The prevention and management of pressure ulcers. Med Clin N Amer 1989;73:1511–24.

    PubMed  CAS  Google Scholar 

  49. Reed BR, Clark RAF. Cutaneous tissue repair: Practical implications of current knowledge: II. J Am Acad Dermatol 1985;13:919–41.

    Article  PubMed  CAS  Google Scholar 

  50. Gregger JL. Potential for trace mineral deficiencies and toxicities in the elderly. In Mineral Homeostasis in the Elderly. Ed. Bales CW, New York, Marcel Dekker, 1989, pp. 171–200.

    Google Scholar 

  51. Thomas DR. Distinguishing starvation from cachexia. Geriatr Clin North Am 2002;18:883–92.

    Google Scholar 

  52. Thomas DR. Weight loss in older adults. Rev Endocrinol Metabol 2005;6:129–36.

    Article  Google Scholar 

  53. Haddad RY, Thomas DR. Enteral Nutrition and Tube Feeding: A Review of the evidence. Geriatr Clin North Am 2002;18:867–82.

    Google Scholar 

  54. Thomas DR. A prospective, randomized clinical study of adjunctive peripheral parenteral nutrition in adult subacute care patients. J Nutr Health Aging 2005;9:321–5.

    PubMed  Google Scholar 

  55. Morley JE. Thomas DR. Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr 2006;83(4):735–43.

    PubMed  CAS  Google Scholar 

  56. Thomas DR. Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia. Clin Nutr 2007;26(4):389–99.

    Google Scholar 

  57. Liso Z, Tu JH, Small CB, Schnipper SM, rosenstreich DL. Increased urine IL-1 levels in aging. Gerontology 1993;39:19–27.

    Article  Google Scholar 

  58. Cederholm T, Whetline B, Hollstrom K, et al. Enhanced generation of Interleukin 1β and 6 may contribute to the cachexia of chronic disease. Am J Clin Nutr 1997;65:876–82.

    PubMed  CAS  Google Scholar 

  59. Ikeda U, Yamamoto K, Akazawa H, et al. Plasma cytokine levels in cardiac chambers of patients with mitral stenssis with congestive heart failure. Cardiology 1996;87:476–8.

    Article  PubMed  CAS  Google Scholar 

  60. Friedman FJ, Campbell AJ, Caradoc-Davies. Hypoalbuminemia in the elderly is due to disease not malnutrition. Clin Exper Gerontol 1985;7:191–203.

    Google Scholar 

  61. Rosenthal AJ, Sanders KM, McMurtry CT, Jacobs MA, Thompson DD, Gheorghiu D, Little KL, Adler RA. Is malnutrition overdiagnosed in older hospitalized patients? Association between the soluble interleukin-2 receptor and serum markers of malnutrition. J Gerontol Series A, Biol Sci Med Sci 1998;53:M81–6.

    Article  CAS  Google Scholar 

  62. Matsuyama N. Takano K. Mashiko T. Jimbo S. Shimetani N. Ohtani H. The possibility of acute inflammatory reaction affects the development of pressure ulcers in bedridden elderly patients. Rinsho Byori – Jpn J Clin Pathol 1999;47(11):1039–45.

    CAS  Google Scholar 

  63. Barone EJ, Yager DR, Pozez AL, Olutoye OO, Crossland MC, Diegelmann RF, Cohen IK. Interleukin-1α and collagenase activity are elevated in chronic wounds. Plast Reconstr Surg 1998;102:1023–7.

    Article  PubMed  CAS  Google Scholar 

  64. Segal JL, Gonzales E, Yousefi S, Jamshidipour L, Brunnemann SR. Circulating levels of IL-2R, ICAM-1, and IL-6 in spinal cord injuries. Arch Physical Med Rehab 1997;78:44–7.

    Article  CAS  Google Scholar 

  65. Bonnefoy M, Coulon L, Bienvenu J, Boisson RC, Rys L. Implication of Cytokines in the aggravation of malnutrition and hypercatabolism in elderly patients with severe pressure sores. Age Ageing 1995;24:37–42.

    Article  PubMed  CAS  Google Scholar 

  66. Wilson MM. Thomas DR. Rubenstein LZ. Chibnall JT. Anderson S. Baxi A. Diebold MR. Morley JE. Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 2005;82(5):1074–81.

    PubMed  CAS  Google Scholar 

  67. Morley JE, Thomas DR. Anorexia and aging: Pathophysiology. Nutrition 1999;15:499–503.

    Article  PubMed  CAS  Google Scholar 

  68. Chasse WT, Balasubramahiam A, Dayal R, et al. Hypothalamic concentration and release of neuropeptide Y into micordialyses is reduced in anorectic tumor bearing rates. Life Sci 1994;54:1869–74.

    Article  Google Scholar 

  69. Leibowitz SF. Neurochemical-neuroendocrine systems in the brain controlling macronutrient intake and metabolism. Trends Neurosci 1992;12:491–7.

    Article  Google Scholar 

  70. Noguchi Y, Yoshikawa T, Marsumoto A, Svaninger G, Gelin J. Are cytokines possible mediators of cancer cachexia? Jpn J Surg 1996;26:467–75.

    Article  CAS  Google Scholar 

  71. Keiler U. Pathophysiology of cancer cachexia. Support Care Cancer 1993;1:290–4.

    Article  Google Scholar 

  72. Straton RJ, Dewit O, Crowe R, Jennings G, Viller RN, Elia M. Plasm leptin, energy intake and hunger following total hip replacement surgery. Clin Sci 1997;93:113–7.

    Google Scholar 

  73. Cederholm T, Arter P, Palmviad J. Low circulation leptin level in protein-energy malnourished chronically ill elderly patients. J Intern Med 1997;242:377–82.

    Article  PubMed  CAS  Google Scholar 

  74. Souba WW. Drug Therapy: Nutritional Support. N Engl J Med 1997;336:41–8.

    Article  PubMed  CAS  Google Scholar 

  75. Atkinson S, Sieffert E, Bihari D. A prospective, randomized, double-blind, controlled clinical trial of enteral immunonutrition in the critically ill. Crit Care Med 1998;26:1164–72.

    Article  PubMed  CAS  Google Scholar 

  76. Milne AC, Potter J, Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Metabolic and Endocrine Disorders Group. Cochrane D Syst Rev. 2008;4.

    Google Scholar 

  77. Thomas DR. Guidelines for the use of orexigenic drugs in long-term care. Nutr Clin Pract 2006;21(1):82–7.

    Article  PubMed  Google Scholar 

  78. Bruerra E, Macmillan K, Hanson J, et al. A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advance cancer. Cancer 1990;66:1279–82.

    Article  Google Scholar 

  79. Allman RM, Goode PS, Patrick MM. Pressure ulcer risk factors among hospitalised patients with severe limitation. J Am Med Assoc 1995;273:865–70.

    Article  CAS  Google Scholar 

  80. Schmoll E, Wilke H, Thole R. Megestrol acetate in cancer cachexia. Seminars Oncol 1991;1(suppl)2:32–4.

    Google Scholar 

  81. Heckmayr M, Gatzenneier U. Treatment of cancer weight loss in patients with advance lung cancer. Oncology 1992;49(suppl)2:32–4

    Article  PubMed  Google Scholar 

  82. Feliu J, gonzalez-Baron M, Berrocal A. Usefulness of megestrol acetate in cancer cachexia and anorexia. Am J Clin Oncol 1992;15:436–40.

    Article  PubMed  CAS  Google Scholar 

  83. Azona C, Castro L, Crespo E, et al. Megestrol acetate therapy for anorexia and weight loss in children with malignant solid tumours. Aliment Pharmacol Ther 1996;10:577–86.

    Article  Google Scholar 

  84. Mantovani G, Maccio A, Bianchi A, Curreli L, Ghiani M, Santona MC, Del Giacco GS. Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy. Springer-Verlag 1995.

    Google Scholar 

  85. Christou NV, Meakins JL, Gordon J, et al. The delayed hypersensitivity response and host resistance in surgical patients: 20 years later. Ann Surg 1995;222:534–48.

    PubMed  CAS  Google Scholar 

  86. Allman RM, Walker JM, Hart MK, et al. Air-fluidized beds or conventional therapy for pressure sores: A randomized trial. Ann Intern Med 1987;107:641–48.

    PubMed  CAS  Google Scholar 

  87. Gorse GJ, Messner RL: Improved pressure sore healing with hydrocolloid dressings. Arch Dermatol 1987;123:766–71.

    Article  PubMed  CAS  Google Scholar 

  88. Inman KJ, Sibbald WJ, Rutledge FS Clinical utility and cost-effectiveness of an air suspension bed in the prevention of pressure ulcers. JAMA 1993;269:1139–43.

    Article  PubMed  CAS  Google Scholar 

  89. Anthony D, Reynolds T, Russell L. An investigation into the use of serum albumin in pressure sore prediction. J Adv Nurs 2000;32:359–65.

    Article  PubMed  CAS  Google Scholar 

  90. Moolten SE. Bedsores in the chronically ill patient. Arch Phys Med Rehabil 1972;53:430–38.

    PubMed  CAS  Google Scholar 

  91. Bennett RG, Bellantoni MF, Ouslander JG: Air-fluidized bed treatment of nursing home patients with pressure sores. J Am Geriatr Soc 1989;37:235–42.

    PubMed  CAS  Google Scholar 

  92. Brandeis GH, Morris JN, Nash DJ, et al. Epidemiology and natural history of pressure ulcers in elderly nursing home residents. J Am Med Assoc 1990;264:2905–9.

    Article  CAS  Google Scholar 

  93. Trumbore LS, Miles TP, Henderson CT, et al. Hypocholesterolemia and pressure sore risk with chronic tube feeding. Clin Res 1990;38:760A.

    Google Scholar 

  94. Breslow RA, Hallfrisch J, Goldberg AP. Malnutrition in tubefed nursing home patients with pressure sores. J Parent Enter Nutr 1991;15:663–8.

    Article  CAS  Google Scholar 

  95. Ferrell BA, Osterweil D, Christenson P: A randomized trial of low-air-loss beds for treatment of pressure ulcers. JAMA 1993;269:494–7.

    Article  PubMed  CAS  Google Scholar 

  96. Guralnik JM, Harris TB, White LR, et al. Occurrence and predictors of pressure sores in the National Health and Nutrition Examination survey follow-up. J Am Geriatrics Soc 1988;36:807–12.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of IM-Geriatric Medicine, Saint Louis University Health Sciences Center, St. Louis, MO

    David R. Thomas

Authors
  1. David R. Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Center for the Study of Aging &, Human Development, Duke University Medical Center, Durham, 27710, USA

    Connie W. Bales

  2. Div. Gerontology, Geriatrics &, Palliative Medicine, University of Alabama, Birmingham, 19th Street South 933, Birmingham, 35294, USA

    Christine S. Ritchie

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Thomas, D.R. (2009). The Relationship of Nutrition and Pressure Ulcers. In: Bales, C., Ritchie, C. (eds) Handbook of Clinical Nutrition and Aging. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-385-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-385-5_12

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-384-8

  • Online ISBN: 978-1-60327-385-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation