Skip to main content
SpringerLink
Log in

Magnetic Resonance Imaging

  • Chapter
  • First Online:
Asymptomatic Atherosclerosis

Part of the book series: Contemporary Cardiology ((CONCARD))

  • 1256 Accesses

Abstract

In the future, the use of imaging methods to quantify the progression and regression of atherothrombosis could play a very strong role in the management of patients. High-resolution, noninvasive cardiovascular magnetic resonance (CMR) imaging has the potential to provide three-dimensional anatomical information about the lumen and the vessel wall. Furthermore, CMR has the ability to characterize atherothrombotic plaque composition and micro-anatomy and therefore to identify lesions at risk to rupture or erosion. The high resolution of CMR and the development of sophisticated contrast agents offer the promise of in vivo molecular imaging of the plaque. This may aid early intervention in both primary and secondary treatment of vascular disease in all arterial beds.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Similar content being viewed by others

ReferenceS

  1. Fayad ZA, Fuster V, Nikolaou K, Becker C. Computed tomography and magnetic resonance imaging for noninvasive coronary angiography and plaque imaging: current and potential future concepts. Circulation 2002;106:2026–34.

    Article  PubMed  Google Scholar 

  2. Hatsukami TS, Ross R, Polissar NL, Yuan C. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation 2000;102:959–64.

    Article  PubMed  CAS  Google Scholar 

  3. Corti R, Fayad ZA, Fuster V, Worthley SG, Helft G, Chesebro J, Mercuri M, Badimon JJ. Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation 2001;104:249–52.

    Article  PubMed  CAS  Google Scholar 

  4. Kang X, Polissar NL, Han C, Lin E, Yuan C. Analysis of the measurement precision of arterial lumen and wall areas using high-resolution MRI. Magn Reson Med 2000;44:968–72.

    Article  PubMed  CAS  Google Scholar 

  5. Chan SK, Jaffer FA, Botnar RM, Kissinger KV, Goepfert L, Chuang ML, O’Donnell CJ, Levy D, Manning WJ. Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden. J Cardiovasc Magn Reson 2001;3:331–338.

    Article  PubMed  CAS  Google Scholar 

  6. Yuan C, Mitsumori LM, Ferguson MS, Polissar NL, Echelard D, Ortiz G, Small R, Davies JW, Kerwin WS, Hatsukami TS. In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation 2001;104:2051–6.

    Article  PubMed  CAS  Google Scholar 

  7. Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation 2002;106:1368–1373.

    Article  PubMed  Google Scholar 

  8. Yuan C, Beach KW, Smith LH, Jr., Hatsukami TS. Measurement of atherosclerotic carotid plaque size in vivo using high resolution magnetic resonance imaging. Circulation 1998;98:2666–71.

    Article  PubMed  CAS  Google Scholar 

  9. Yuan C, Zhang SH, Polissar NL, Echelard D, Ortiz G, Davis JW, Ellington E, Ferguson MS, Hatsukami TS. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation 2002;105:181–185.

    Article  PubMed  Google Scholar 

  10. Blake GJ, Ostfeld RJ, Yucel EK, Varo N, Schonbeck U, Blake MA, Gerhard M, Ridker PM, Libby P, Lee RT. Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study with high-resolution MRI. Arterioscler Thromb Vasc Biol 2003;23:e11–e14.

    Article  PubMed  CAS  Google Scholar 

  11. Summers RM, Andrasko-Bourgeois J, Feuerstein IM, Hill SC, Jones EC, Busse MK, Wise B, Bove KE, Rishforth BA, Tucker E, Spray TL, Hoeg JM. Evaluation of the aortic root by MRI: insights from patients with homozygous familial hypercholesterolemia. Circulation 1998;98:509–518.

    Article  PubMed  CAS  Google Scholar 

  12. Jaffer FA, O’Donnell CJ, Larson MG, Chan SK, Kissinger KV, Kupka MJ, Salton C, Botnar RM, Levy D, Manning WJ. Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study. Arterioscler Thromb Vasc Biol 2002;22:849–854.

    Article  PubMed  CAS  Google Scholar 

  13. Taniguchi H, Momiyama Y, Fayad ZA, Ohmori R, Ashida K, Kihara T, Hara A, Arakawa K, Kameyama A, Noya K, Nagata M, Nakamura H, Ohsuzu F. In vivo magnetic resonance evaluation of the associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography. Am Heart J 2004;148(1):137–143.

    Article  PubMed  Google Scholar 

  14. Weiss CR, Arai AE, Bui MN, Agyeman KO, Waclawiw MA, Balaban RS, Cannon RO. Arterial wall MRI characteristics are associated with elevated serum markers of inflammation in humans. J Magn Reson Imaging 2001;14:698–704.

    Article  PubMed  CAS  Google Scholar 

  15. Zhao XQ, Yuan C, Hatsukami TS, Frechette EH, Kang XJ, Maravilla KR, Brown BG. Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study. Arterioscler Thromb Vasc Biol 2001;21:1623–1629.

    Article  PubMed  CAS  Google Scholar 

  16. Corti R, Osende JI, Fallon JT, Fuster V, Mizsei G, Jneid H, Wright SD, Chaplin WF, Badimon JJ. The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging. Journal of the American College of Cardiology 2004;43:464–473.

    Article  PubMed  CAS  Google Scholar 

  17. Fayad ZA, Fuster V, Fallon JT, Jayasundera T, Worthley SG, Helft G, Aguinaldo JG, Badimon JJ, Sharma SK. Noninvasive in vivo human coronary artery lumen and wall imaging using black-blood magnetic resonance imaging. Circulation 2000;102:506–510.

    Article  PubMed  CAS  Google Scholar 

  18. Itskovich VV, Mani V, Mizsei G, Aguinaldo JG, Samber DD, Macaluso F, Wisdom P, Fayad ZA. Parallel and nonparallel simultaneous multislice black-blood double inversion recovery techniques for vessel wall imaging. J Magn Reson Imaging 2004;19:459–67.

    Article  PubMed  Google Scholar 

  19. Mani V, Itskovich VV, Szimtenings M, Aguinaldo JG, Samber DD, Mizsei G, Fayad ZA. Rapid extended coverage simultaneous multisection black-blood vessel wall MR imaging. Radiology 2004;232(1):281–288.

    Article  PubMed  Google Scholar 

  20. Rudd JH, Myers KS, Sanz J, Fayad ZA. Multimodality imaging of atherosclerosis (magnetic resonance imaging/computed tomography/positron emission tomography-computed tomography). Top Magn Reson Imaging 2007;18(5):379–388.

    Article  PubMed  Google Scholar 

  21. Momiyama Y, Fayad ZA. Aortic plaque imaging and monitoring atherosclerotic plaque interventions. Top Magn Reson Imaging 2007;18(5):349–355.

    Article  PubMed  Google Scholar 

  22. Sanz J, Fayad ZA. Imaging of atherosclerotic cardiovascular disease. Nature 2008;451(7181):953–957.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology and Department of Cardiology, Mount-Sinai School of Medicine, New York, NY, USA

    Zahi A. Fayad

Authors
  1. Zahi A. Fayad
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Endothelix, Inc., El Rio 8275, Houston, 77054, USA

    Morteza Naghavi

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Fayad, Z.A. (2011). Magnetic Resonance Imaging. In: Naghavi, M. (eds) Asymptomatic Atherosclerosis. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-179-0_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-179-0_26

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-178-3

  • Online ISBN: 978-1-60327-179-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation