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Neocortical Epilepsy

α-Methyl-L-Tryptophan and Positron Emission Tomography Studies

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Bioimaging in Neurodegeneration

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

A review of the use of a radioactively labeled tracer, α-methyl-L-tryptophan (α-MTrp), proposed for the study of the brain serotonin synthesis in normal and diseased brain, is presented. Serotonin is one of many brain neurotransmitters shown to be involved in many brain processes, and an alteration of its biochemistry has been proposed to be present in many brain diseases and disorders. Labeled α-MTrp in normal brain and probably in affective disorders can be used for the measurement of the regional serotonin synthesis, but in some diseases like epilepsy the uptake of the tracer is probably related more to the altered tryptophan metabolism, mainly via the kynurenine pathway. A summary of the published data indicates that positron emission tomography after injection of α-[11C]MTrp could be very valuable in determining the epileptic focus; however, it is not possible to get identification in all cases evaluated.

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Authors and Affiliations

  1. Department of Pediatrics, Japanese Red Cross Nagoya First Hospital, Nagoya, Aichi, Japan

    Jun Natsume MD, PhD

  2. Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

    Andrea Bernasconi MD & Mirko Diksic PhD

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  1. Jun Natsume MD, PhD
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  2. Andrea Bernasconi MD
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  3. Mirko Diksic PhD
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Editors and Affiliations

  1. Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY

    Patricia A. Broderick PhD

  2. Department of Neurology, New York University School of Medicine, New York, NY

    Patricia A. Broderick PhD  & Edwin H. Kolodny MD  & 

  3. NYU Comprehensive Epilepsy Center, New York, NY

    Patricia A. Broderick PhD

  4. Department of Chemistry and Physical Sciences, Pace University, Pleasantville, NY

    David N. Rahni PhD

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Natsume, J., Bernasconi, A., Diksic, M. (2005). Neocortical Epilepsy. In: Broderick, P.A., Rahni, D.N., Kolodny, E.H. (eds) Bioimaging in Neurodegeneration. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59259-888-5_11

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