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Excitatory effects of kynurenine and its metabolites, amino acids and convulsants administered into brain ventricles: Differences between rats and mice

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Summary

When introduced intracerebroventricularly, quinolinic acid appeared to be the only kynurenine metabolite among those tested (L- and DL-kynurenine sulfate, kynurenic and nicotinic acids, nicotinamide) which induced locomotor excitement and clonic scizures in rats; in high dosage all exhibited convulsant action in mice. L-Kynurenine sulfate (500μg) induced continuous rotation in rats around a longitudinal axis in one or other direction. It also potentiated the convulsant effect of strychnine sulfate and caffeine. Neither the excitatory amino acids, L-glutamic and L-aspartic acids nor the inhibitory amino acids, GABA, glycine and taurine induced excitement or scizures in rats but did in mice. In rats, GABA, glycine and taurine induced sedation, side position and discoordination. The convulsants, strychnine sulfate and pentylenetetrazole, induced scizures both in rats and mice. Differences between species may derive from the better access of intracerebroventricularly administered drugs to mouse hippocampus. Thus mice may be preferable for studies of this type on excitatory amino acids (including kynurenine pathway metabolites) and rats for those on inhibitory amino acids.

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  1. I. P. Lapin

    Present address: Laboratory of Psychopharmacology, Bekhterev Psychoneurological Research Institute, Leningrad, USSR

Authors and Affiliations

  1. Laboratory of Psychopharmacology, Bekhterev Psychoneurological Research Institute, Leningrad, USSR

    I. B. Prakhie & I. P. Kiseleva

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  1. I. P. Lapin
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  2. I. B. Prakhie
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  3. I. P. Kiseleva
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Lapin, I.P., Prakhie, I.B. & Kiseleva, I.P. Excitatory effects of kynurenine and its metabolites, amino acids and convulsants administered into brain ventricles: Differences between rats and mice. J. Neural Transmission 54, 229–238 (1982). https://doi.org/10.1007/BF01254932

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  • DOI: https://doi.org/10.1007/BF01254932

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