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Branched Chain Amino Acids and Organ Transplantation

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Branched Chain Amino Acids in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

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Abstract

Protein-energy malnutrition is common in patients with end-stage liver disease requiring liver transplantation (LT). Pretransplant nutritional condition is closely associated with posttransplant risk of morbidity and mortality. We reported that the absence of preoperative administration of a nutrient mixture enriched with branched-chain amino acids was an independent risk factor of posttransplant sepsis. Therefore, accurate nutritional assessment as well as adequate perioperative nutritional treatment is essential for improving outcomes after LT. Moreover, the overall survival rate in patients with low skeletal muscle mass was found to be significantly lower than in patients with normal/high skeletal muscle mass. Perioperative nutritional therapy including branched-chain amino acids is useful for patients with sarcopenia, whose prognosis is poor without nutritional therapy.

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Author information

Authors and Affiliations

  1. Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cha, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Toshimi Kaido M.D., Ph.D.

Authors
  1. Toshimi Kaido M.D., Ph.D.
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Correspondence to Toshimi Kaido M.D., Ph.D. .

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Editors and Affiliations

  1. Intensive Care, Barnet and Chase Farm Hospitals, Royal Free London NHS Foundation Trust, London, United Kingdom

    Rajkumar Rajendram

  2. Diabetes and Nutritional Sciences, Kings College London, London, United Kingdom

    Victor R. Preedy

  3. Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Kaido, T. (2015). Branched Chain Amino Acids and Organ Transplantation. In: Rajendram, R., Preedy, V., Patel, V. (eds) Branched Chain Amino Acids in Clinical Nutrition. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1914-7_14

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  • DOI: https://doi.org/10.1007/978-1-4939-1914-7_14

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1913-0

  • Online ISBN: 978-1-4939-1914-7

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