Abstract
It is important to emphasize that the biochemical systems participating in humoral hemodynamic regulation may function at any level of the circulatory homeostasis: in the blood as a biological fluid constantly circulating along the vessels, at the microcirculatory bed where the exchange with tissues is realized, on the tonic activity of the resistive and capacitance vessels, defining the systemic blood pressure rate and organ redistribution, or, finally, on the main motive force of the blood, the heart. The interrelations of some molecular factors form the biochemical basis for the interaction of the main humoral systems. These factors are kallikrein for kinins and converting enzyme for the renin-angiotensin system, 9-ketoreductase and phospholipase for kinin and prostaglandin systems, and Hageman factors for coagulation, fibrinolysis, and kininogenesis systems. This main scheme includes “functional” connections, which are defined by a physiological interaction, and those between the central and peripheral nervous systems. We may, evidently, postulate an important biological regularity of a multifunctional participation of the same physiologically active factors in maintaining circulatory homeostasis. On the other hand, we have to emphasize the functional unity and joint correlating actions of different biochemical blood systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Chernukh, A. M., Alexeyev, O. V., and Ionov, B. V. 1981. [Interaction of erythrocytes in aggregation according to raster electron microscopy.] Biull. Eksp. Biol. Med. 2:226–228.
Chernukh, A. M., and Gomazkov, O. A. 1976. [On regularity and pathogenetic role of kallikrein-kinin system of organism.] Patol. Fisiol. Eksp. Ther. 1:5–16.
Chernukh, A. M., Gomazkov, O. A., Komissarova, N. V., and Lantsberg, L. 1981. [Changes in indices of Hageman factor system in human adaptation to intensive physical exercise.] Patol. Fisiol. Eksp. Ther. 5:25–28.
Chernukh, A. M., Oehme, P., and Gomazkov, O. A. 1980. [Hemodynamic characteristics of the polypeptide substance P in comparison with bradykinin and prostaglandin E1.] Biull. Eksp. Biol. Med. 9:259–260.
Derkx, F. H., Bouma, B. N., and Schalekamp, M. 1979. An intrinsic factor XII-prekallikrein-dependent pathways activates the human plasma renin-angiotensin system. Nature280:315–316.
Donaldson, V. H., Kleniewski, J., Saito, H., and Sayed, J. K. 1977. Prekallikreindeficiency and Fitzgerald trait clotting defect. Evidence that high molecular weight kininogen and prekallikrein exist as a complex in normal human plasma. J. Clin. Invest. 60:571–584.
Eliseeva, T. E., and Orekhovitch, V. N. 1963. [Isolation and study of specificity of carboxycathepsin.] Dokl. Akad. Nauk. SSSR153:954–956.
Frey, E. K., and Kraut, H. 1928. Ein neues Kreislaufhormon und seine Wirkung. Arch. Exp. Pathol. Pharmacol. 133:1–56.
Frey, E. K., Kraut, H., and Werle, E. 1950. Kallikrein (Padutin). Enke, Stuttgart.
Gomazkov, O. A. 1973. [Vasoactive kinins in physiology and pathology of cardiovascular system.] Kardiologiia7:130–144.
Gomazkov, O. A. 1974. Das Kallikrein-Klinin-System bei Myokardischemie und Herzinfarct—Experimentelle Untersuchungen. Med. Welt25:804–807.
Gomazkov, O. A., and Komissarova, N. V. 1976. [Method of simultaneous determination of precursors of kallikrein, plasmin, thrombin and their inhibitors in human blood plasma.] Biull. Eksp. Biol. Med. 5:632–634.
Gomazkov, O. A., Shimkovitch, M. V., and Chernukh, A. M. 1977. [Interrelation between kininase and angiotensin-converting activity under normal condition and in experimentally induced myocardial infarction.] Kardiologiia17:103–108.
Gordon, R. J. 1974. Potential significance of plasma viscosity and hematocrit variations in myocardial ischemia. Am. Heart J. 87:175–182.
Griffin, J. 1978. Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII). Proc. Natl. Acad. Sci. U.S.A. 75:1998–2002.
Meier, H. L., Pierce, J. V., Colman, R. W., and Kaplan, A. P. 1977. Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein. J. Clin. Invest. 60:18–31.
Moncada, S., Mullane, K. M., and Vane, J. R. 1979. Prostacycline release by bradykinin in vivo. Br. J. Pharmacol. 66:96P-97P.
Movat, H. Z. 1978. The kinin system: Its relation to blood coagulation, fibrinolysis and formed elements of the blood. Rev. Physiol. Biochem. Pharmacol. 84:143–202.
Osmond, D. H., Lo, E. K., Loh, A. Y., Zingg, E. A., and Hedlin, A. H. 1978. Kallikrein and plasmin as activators of inactive renin. Lancet2:1375.
Rocha e Silva, M., Beraldo, W., and Rosenfeld, G. 1949. Bradykinin, a hypotensive and smooth muscle stimulating factor releasing from plasma globulin by snake venom and by trypsin. Am. J. Physiol. 156:261–273.
Sealey, J. E., Altas, S. A., and Laragh, J. 1978. Linking the kallikrein and kinin system via activation of inactive renin. New data and hypothesis. Am. J. Med. 65:994–1000.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer Science+Business Media New York
About this chapter
Cite this chapter
Chernukh, A.M., Gomazkov, O.A. (1983). Vasoactive Peptides and Regulation of Hemodynamics in Different Functional States of the Organism. In: Chazov, E., Saks, V., Rona, G. (eds) Advances in Myocardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4441-5_18
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4441-5_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-4443-9
Online ISBN: 978-1-4757-4441-5
eBook Packages: Springer Book Archive