Abstract
The evidence is quite solid that a feedback inhibition system of the pancreatic exocrine secretion exists in a number of animal species. Whether or not such a regulatory system is operative in man remains controversial. Studies in normal human subjects which have been interpreted as evidence that such a regulatory system is not present in man suffer from serious flaws in experimental design, such as the inability to completely divert pancreatic enzymes (chymotrypsin, elastase) as important principles in this control mechanism. Studies in both normal human subjects and patients with chronic pancreatitis will be reviewed.
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References
Adrian, T. E., Pasquali, C., Pescosta, F., Bacarese-Hamilton, A. J., and Bloom, S. R. (1982). Soya-induced pancreatic hypertrophy and rise of circulating cholecystokinin. Gut, 23, A889.
Alumot, E. and Nitsan, Z. (1961). The influence of soybean antitrypsin on the intestinal proteolysis of the chick. J. Clin. Nutr.,73,71–75.
Brand, S. J. and Morgan, R. G. H. (1981). The release of rat intestinal cholecystokinin after oral trypsin inhibitor measured by bio-assay. J. Physiol., 319, 325–343.
Dlugosz, J., Folsch, U. R., and Creutzfeldt, W. (1983). Inhibition of intraduodenal trypsin does not stimulate exocrine pancreatic secretion in man. Digestion, 26, 197–204.
Folsch, U. R., Mustroph, D., Schafmayer, A., Becker, H. D., and Creutzfeldt, W. (1984). Elevated CCK plasma concentrations during acute and chronic feeding of soybean flour. Digestion, 30, 88.
Folsch, U. R., Schafmayer, A., Ebert, R., Becker, H. D., and Creutzfeldt, W. (1984). Elevated plasma cholecystokinin concentrations in exocrine pancreatic atrophy in the rat. Digestion, 29, 60–64.
Geratz, J. D. and Hurt, J. P. (1970). Regulation of pancreatic enzyme levels by trypsin inhibitors. Am. J. Physiol., 219, 705.
Goodale, R. L., Liener, I. E., Desmukh, A., Frick, T., Satterberg, T., Ward, G., and Borner, J. W. (1985). Do trypsin inhibitors affect feedback control of human pancreatic secretion? Dig. Dis. Sci., 30, 972.
Green, G. M. and Lyman, R. L. (1971). Chymotrypsin inhibitor stimulation of pancreatic enzyme secretion in the rat. Proc. Soc. Exp. Biol. Med., 136, 649.
Grossman, M. I. (1958). Pancreatic secretion in the rat. Am J. Physiol., 194, 535–539.
Hotz, J., Ho, S. B., Go, V. L. W., and DiMagno, E. P. (1983). Short-term inhibition of duodenal tryptic activity does not affect human pancreatic, biliary, or gastric function. J. Lab. Clin. Med., 101, 488–495.
Ihse, I. and Lilja, P. (1970). Effects of intestinal amylase and trypsin on pancreatic secretion in the pig. Scand. J. Gastroenterol., 14, 1009–1013.
Ihse, I., Lilja, P., and Lundquist, I. (1977). Feedback regulation of pancreatic enzyme secretion by intestinal trypsin in man. Digestion, 15, 303–308.
Ihse, I., Lilja, P., and Lundquist, I. (1979). Trypsin as a regulator of pancreatic secretion in the rat. Scand. J. Gastroenterol., 14, 873–880.
Isaksson, G. and Ihse, I. (1983). Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis. Dig. Dis. Sci., 28, 97–102.
Krawisz, B. R., Miller, L. J., DiMagno, E. P., and Go, V. L. W. (1980). In the absence of nutrients, pancreatic-biliary secretions in the jejunum do not exert feedback control of human pancreatic or gastric function. J. Lab. Clin. Med., 95, 13–18.
Liddle, R. A., Goldfine, I. D., and Williams, J. A. (1984). Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology, 87, 542–549.
Lyman, R. L. (1957). The effect of raw soybean meal and trypsin inhibitor on the intestinal and pancreatic nitrogen in the rat. J. Nutr., 62, 285–294.
Lyman, R. L., Olds, B. A., and Green, G. M. (1974). Chymotrypsin in the intestine of rats fed soybean trypsin inhibitor and its inability to suppress pancreatic enzyme secretions. J. Nutr., 104, 105–110.
Owyang, C., Dismond, S., and May, D. (1984). Feedback regulation of pancreatic enzyme secretion in man is stimulus specific. Gastroneterology, 86, 1205.
Sale, J. K., Goldberg, D. M., Fawcett, A. N., and Wormsley, K. G. (1977). Chronic and acute studies indicating absence of exocrine pancreatic feedback inhibition in dogs. Digestion, 15, 540–555.
Schneeman, B. O. and Lyman, R. L. (1975). Factors involved in intestinal feedback regulation of pancreatic enzyme secretion in the rat. Proc. Soc. Exp. Med. Biol., 148, 897–903.
Slaff, J. I, Jacobson, D., Tillman, C. R., Curington, C., and Toskes, P. P. (1984). Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology, 87, 44–52.
Slaff, J. I., Wolfe, M. M., and Toskes, P. P. (1985). Elevated fasting plasma cholecystokinin levels in pancreatic exocrine impairment: evidence to support feedback regulation. J. Lab. Clin. Med., 105, 282–285.
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© 1986 Plenum Press, New York
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Toskes, P.P. (1986). Negative Feedback Inhibition of Pancreatic Exocrine Secretion in Humans. In: Friedman, M. (eds) Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods. Advances in Experimental Medicine and Biology, vol 199. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0022-0_9
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DOI: https://doi.org/10.1007/978-1-4757-0022-0_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0024-4
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