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Genetic Contributions to Kindling: An Experimental Approach

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Kindling 4

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 37))

Abstract

The development of kindled seizures has been shown to be influenced by genetic factors. The establishment of kindling-prone and kindling-resistant rat populations through selective breeding, along with the reported variations in kindling rates among inbred strains of mice strongly suggests the contribution of genetics to kindling [2,6,17,18]. The rapid kindling rates of genetically epilepsy prone rats [29] and El mice [13] in comparison with appropriate controls provide additional examples of the influence of genetic factors on kindled seizure development. However, to date, no systematic analysis of these factors has been reported for kindling-induced seizures.

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Author information

Authors and Affiliations

  1. Comprehensive Epilepsy Program, Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA

    Craig D. Applegate & James L. Burchfiel

  2. Department of Neurology, The Children’s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Paul E. Neumann

Authors
  1. Craig D. Applegate
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  2. James L. Burchfiel
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  3. Paul E. Neumann
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Editor information

Editors and Affiliations

  1. Neurosciences and Neurology, University of British Columbia, Vancouver, British Columbia, Canada

    Juhn A. Wada

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© 1990 Plenum Press, New York

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Applegate, C.D., Burchfiel, J.L., Neumann, P.E. (1990). Genetic Contributions to Kindling: An Experimental Approach. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5796-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5798-8

  • Online ISBN: 978-1-4684-5796-4

  • eBook Packages: Springer Book Archive

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