Skip to main content
Log in

Analysis of major gene effects using recombinant inbred strains and related congenic lines

  • Published:
Behavior Genetics Aims and scope Submit manuscript

Abstract

Methods are presented for the detection of major gene effects on continuous phenotypes, using recombinant inbred strains of mice and related congenic lines. Considerations of analysis and limitations on the utility of these genetic resources are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bailey, D. W., (1971). Recombinant inbred strains.Transplantation 11:325–327.

    Google Scholar 

  • Bailey, D. W. (1975). Genetics of histocompatibility in mice. I. New loci and congenic lines.Immunogenetics 2:249–256.

    Google Scholar 

  • Campbell, D. T., and Fiske, D. W. (1959). Convergent and discriminant validation by the multitrait-multimethod matrix.Psychol. Bull. 56:81–105.

    Google Scholar 

  • Castellano, C., Eleftheriou, B. E., Bailey, D. W., and Oliverio, A. (1974). Chlorpromazine and avoidance behavior: A genetic analysis.Psychopharmacologia 34:309–316.

    Google Scholar 

  • Cohen, J. (1969).Statistical Power Analysis for the Behavioral Sciences, Academic Press, New York.

    Google Scholar 

  • Cohen, J., and Cohen, P. (1975).Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences, Lawrence Erlbaum, Hillsdale, New Jersey.

    Google Scholar 

  • Eleftheriou, B. E., and Bailey, D. W., (1972). A gene controlling plasma serotonin levels in mice.J. Endocrinol. 55:225–226.

    Google Scholar 

  • Green, E. L. (1966). Breeding systems. In Green, E. L. (Ed.),Biology of the Laboratory Mouse, McGraw-Hill, New York.

    Google Scholar 

  • Keppel, G. (1973).Design and Analysis: A Researcher's Handbook, Prentice-Hall, Englewood Cliffs, New Jersey.

    Google Scholar 

  • Oliverio, A., Eleftheriou, B. E., and Bailey, D. W. (1973). Exploratory activity: Genetic analysis of its modification by scopolamine and amphetamine.Physiol. Behav. 10:893–899.

    Google Scholar 

  • Taylor, B. A. (1976). Development of recombinant inbred lines of mice.Behav. Genet. 6:118.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klein, T.W. Analysis of major gene effects using recombinant inbred strains and related congenic lines. Behav Genet 8, 261–268 (1978). https://doi.org/10.1007/BF01072828

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01072828

Key Words

Navigation