Abstract
The limiting factor in the use of mouse chimeras for the revelation of detailed fate maps during embryogenesis is the lack of suitable cell marker systems. This limitation is evident when the list of available chimeric or mosaic markers is examined and compared to the criteria for an ideal marker system. An ideal cell marker should (1) be expressed in all descendants of a cell; (2) be present in all cells of a tissue or organism; (3) be cell autonomous; (4) be cell localized; (5) exist in variant forms which are selectively neutral; (6) have variant forms which can be detected in histologic sections; and (7) have variants which are expressed early in embryogenesis.
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Gearhart, J., Oster-Granite, M.L. (1978). Antibodies to Allozymes as Potential Cell Markers for Chimeric Mouse Studies. In: Russell, L.B. (eds) Genetic Mosaics and Chimeras in Mammals. Basic Life Sciences, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3390-6_9
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DOI: https://doi.org/10.1007/978-1-4684-3390-6_9
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