Abstract
The autosomal variation and the genetic control of GPI has been determined by a comparison of electrophoretic patterns of F1 and backcross progeny of three inbred strains of mice. The locus controlling the production of GPI in the mouse has been designated Gpi-1. Two alleles at this locus have been described and designated Gpi-1 a and Gpi-1 b, which represent, respectively, the slow and fast electrophoretic forms. Twenty-seven inbred strains of mice have been classified for these two alleles. The absence of close linkage of Gpi-1 to seven other genetic loci has been determined. It has been demonstrated that the polymorphism of Gpi-1 is widely distributed in feral mice. GPI was expressed in vitro and in four types of malignant tumors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Augustinsson, K. B., and Disson, B. (1959). Esterases in the milk and blood plasma of swine. 2. Activities at different stages during the lactation and suckling periods, and plasma arylesterases as a gene-controlled enzyme. Biochem. J. 71 484.
Bodansky, O. (1953). Serum phosphohexose isomerase. J. Biol. Chem. 202 829.
Bodansky, O. (1954a). Serum phosphohexose isomerase in cancer. I. Method of determination and establishment of normal values. Cancer 7 1191.
Bodansky, O. (1954b). Serum phosphohexose isomerase in cancer. II. As an index of tumor growth in metastatic carcinoma of the breast. Cancer 7 1200.
Bodansky, O. and Schwartz, M. R. (1966). Phosphohexose isomerase: clinical aspects. In Wood, W. A. (ed.), Methods of Enzymology, Vol. 9, Academic Press, New York, p. 568.
Carter, N. D., and Parr, C. W. (1967). Isoenzymes of phosphoglucose isomerase in mice. Nature 216 511.
Carter, N. D., Fildes, R. A., Fitch, L. I., and Parr, C. W. (1968). Genetically determined electrophoretic variations of human phosphogluconate dehydrogenase. Acta Genet. Basel 18 109.
Detter, J. C., Ways, P. O., Giblett, E. R., Baughan, M. A., Hopkinson, D. A., Povey, S., and Harris, H. (1968). Inherited variations in human phosphohexose isomerase. Ann. Human Genet. (London) 31 329.
Ehrenstein, G. von (1966). Translation variations in the amino acid sequence of the alpha chain of rabbit hemoglobin. Cold Spring Harbor Symp. Quant. Biol. 31 705.
Epstein, C. J., and Schechter, A. N. (1968). An approach to the problem of conformational isozymes. Symposium on isozymes. Proc. N.Y. Acad. Sci. 151 85.
Garen, A., and Siddiqi, D. (1962). Suppression of mutations in the alkaline phosphatase structural cistron of E. coli. Proc. Natl. Acad. Sci. 48 1121.
Gartler, M. C., and Pious, D. A. (1966). Genetics of mammalian cell cultures. Humangenetik 2 83.
Harris, H. (1966). Enzyme polymorphisms in man. Proc. Roy. Soc. London B 164 298.
Harris, H., Hopkinson, D. A., Luffman, J. E., and Rapley, S. (1968). Electrophoretic variation in erythrocyte enzymes. In Beutler, E. (ed.), Hereditary Disorders of Erythrocyte Metabolism, City of Hope Symposium Series, Vol. 1, Grune and Stratton, New York, pp. 1–65.
Henderson, N. S. (1965). Isozymes of isocitrate dehydrogenase: subunit structure and intracellular location. J. Exptl. Zool. 158 263.
Henderson, N. S. (1966). Isozymes and genetic control of NADP-malate dehydrogenase in mice. Arch. Biochem. Biophys. 117 28.
Kitto, G. B., Wassarman, P. M., and Kaplan, N. O. (1966). Enzymatically active conformers of mitochondrial malate dehydrogenase. Proc. Natl. Acad. Sci. 56 578.
Lohman, K. (1933). Formation and hydrolysis of phosphate esters. Synthesis of natural hexosemonophosphate from its components. Biochem. Z. 262 137.
Roe, J. H. (1934). A colorimetric method for the determination of fructose in blood and urine. J. Biol. Chem. 107 15.
Roe, J. H., Epstein, J. H., and Goldstein, N. P. (1949). Photometric method for the determination of inulin in plasma and urine. J. Biol. Chem. 178 839.
Rose, I. A. (1962). Mechanism of C-H bond cleavage in aldolase and isomerase reactions. Brookhaven Symp. Biol. 15 293.
Ruddle, F. H. (1969). Isozymic variants as genetic markers in somatic cell populations in vitro. Natl. Cancer Inst. Monograph 29 9.
Ruddle, F. H., and Roderick, T. H. (1965). The genetic control of three kidney esterases in C57BL/6J and Rf/J mice. Genetics 51 445.
Ruddle, F. H., and Roderick, T. H. (1966). The genetic control of two types of esterases in inbred strains of the mouse. Genetics 54 191.
Ruddle, F. H., and Roderick, T. H. (1968). Second conf. multiple molecular forms of enzymes. Ann. N. Y. Acad. Sci. 151 531.
Ruddle, F. H., Shows, T. B., and Roderick, T. H. (1968). Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus). Genetics 58 599.
Ruddle, F. H., Shows, T. B., Chen, T. R., and Silagi, S. (in preparation).
Schwartz, D. (1964). A second hybrid enzyme in maize. Proc. Natl. Acad. Sci. 51 602.
Schwartz, M. K., and Bodansky, O. (1966). Relationship of the electrophoretic patterns of phosphohexose isomerase and glutamic oxalacetic transaminase in human tissues to the patterns in serum of patients with neoplastic disease. Am. J. Med. 40 231.
Shows, T. B., and Ruddle, F. H. (1968). Malate dehydrogenase: evidence for tetrameric structure in Mus musculus. Science 160 1356.
Shows, T. B., Ruddle, F. H., and Roderick, T. H. (1969). Phosphoglucomutase electrophoretic variants in the mouse. Biochem. Genet. 3 25.
Spencer, N., Hopkinson, D. A., and Harris, H. (1964). Phosphoglucomutase polymorphism in man. Nature 204 742.
Staats, J. (1966). Nomenclature. In Green, E. L. (ed.), Biology of the Laboratory Mouse, 2nd ed., McGraw-Hill, New York, pp. 45–50.
Stein, M. W. (1955). Phosphohexoisomerases from muscle. In Colowick, S., and Kaplan, N. (eds.), Methods in Enzymology, Vol. 1, Academic Press, New York, pp. 299–306.
Topper, Y. J. (1957). On the mechanism of action of phosphoglucose isomerase and phosphomannose isomerase. J. Biol. Chem. 225 419.
Tsuboi, K. K., Estrada, J., and Hudson, P. B. (1958). Enzymes of the human erythrocytes. IV. Phosphoglucose isomerase, purification and properties. J. Biol. Chem. 231 19.
Wallace, M. E. Nature (in press).
Author information
Authors and Affiliations
Additional information
Supported by U.S. Public Health Service Grants GM-09966, from General Medical Sciences, and GY 4193.
Rights and permissions
About this article
Cite this article
DeLorenzo, R.J., Ruddle, F.H. Genetic control of two electrophoretic variants of glucosephosphate isomerase in the mouse (Mus musculus). Biochem Genet 3, 151–162 (1969). https://doi.org/10.1007/BF00520350
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00520350