Abstract
Until some 10 years ago our knowledge of the structure of interphase nuclei was limited to a few aspects of chromosome arrangement. As early as 1885, Carl Rabl showed that chromosomes remain in the same polarized orientation through interphase that they had assumed in anaphase. This Rabl orientation, as it has been called, is often still visible in the following prophase (Fig. 14.1a, b; Heitz, 1933). Rabl also found that chromosomes in interphase do not form a tangle of threads, but that each of them occupies a defined territory, a domain. Recent studies done by creating prematurely condensed chromosomes (Sperling and Lüdtke, 1981; Cremer et al., 1982) and by hybridizing specific DNA probes to nuclei (Manuelidis, 1985; Schardin et al., 1985) have shed new light on the nuclear structure. The latter technique, especially, has made visible the domains of individual chromosomes and has enabled the determination of numerical and structural chromosome abnormalities in interphase nuclei (Cremer et al., 1988).
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© 1993 Springer-Verlag New York, Inc.
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Therman, E., Susman, M. (1993). Chromosome Arrangement in Interphase and in Differentiated Nuclei. In: Human Chromosomes. Springer Study Edition. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0529-3_14
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DOI: https://doi.org/10.1007/978-1-4684-0529-3_14
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