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c-erbB2 expression predicts tamoxifen efficacy in breast cancer patients

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Prognostic variables in node-negative and node-positive breast cancer

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Abstract

c-erbB2 is a proto-oncogene that encodes the trans-membrane protein p185. This protein shares considerable sequence and structure homology with members of the epidermal growth factor receptor family and it is believed to cooperate with these receptors in the signal transduction process in order to control cell proliferation. Overexpression of c-erbB2, with or without gene amplification, is frequently found in breast cancer, and a body of evidence suggests it is implicated in the development of resistance to the antiestrogen tamoxifen. Scientific evidence strongly supports a correlation between c-erbB2 overexpression and lack of efficacy of tamoxifen in both advanced and adjuvant settings. However, given the important therapeutic repercussion of this topic, further studies are required before c-erbB2 evaluation can be routinely used to select patients who are likely to benefit from tamoxifen administration.

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Authors and Affiliations

  1. Cattedra di Oncologia Medica, Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università “Federico II”, Napoli, Italy

    Sabino De Placido, Chiara Carlomagno, Michelino De Laurentiis & Angelo Raffaele Bianco MD, PhD

  2. Cattedra di Oncologia Medica, Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università “Federico II”, via Sergio Pansini, 5, 80131, Napoli, Italy

    Angelo Raffaele Bianco MD, PhD

Authors
  1. Sabino De Placido
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  2. Chiara Carlomagno
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  3. Michelino De Laurentiis
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  4. Angelo Raffaele Bianco MD, PhD
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Giampietro Gasparini

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© 1998 Springer Science+Business Media Dordrecht

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De Placido, S., Carlomagno, C., De Laurentiis, M., Bianco, A.R. (1998). c-erbB2 expression predicts tamoxifen efficacy in breast cancer patients. In: Gasparini, G. (eds) Prognostic variables in node-negative and node-positive breast cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5195-9_12

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  • DOI: https://doi.org/10.1007/978-1-4615-5195-9_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7366-7

  • Online ISBN: 978-1-4615-5195-9

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