Abstract
Immunocytochemistry, in situ hybridization, and electrophysiological techniques have demonstrated the presence of excitatory amino acid (EAA) receptors in the supraoptic nuclei(1–4). A role for EAA regulation of vasopressin (VP) release is suggested by the ability of the non-specific EAA antagonist, kynureic acid, to inhibit osmotically stimulated VP release from explants of the hypothalamo-neurohypophyseal system (HNS)(5). In addition, both N-methyl-D-aspartate (NMDA) receptor antagonists (AP5 and MK801) and the non-NMDA receptor antagonist, DNQX, applied independently inhibit osmotically stimulated VP release implicating the importance of both classes of glutamate receptors in the regulation of VP release.
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© 1998 Springer Science+Business Media New York
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Morsette, D.J., Swenson, K.L., Badre, S.E., Sladek, C.D. (1998). Regulation of Vasopressin Release by Ionotropic Glutamate Receptor Agonists. In: Zingg, H.H., Bourque, C.W., Bichet, D.G. (eds) Vasopressin and Oxytocin. Advances in Experimental Medicine and Biology, vol 449. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4871-3_14
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DOI: https://doi.org/10.1007/978-1-4615-4871-3_14
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