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BCL-2: Physiology and role in neoplasia

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Oncogenes and Tumor Suppressor Genes in Human Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 63))

Abstract

Deregulation of proto-oncogenes or inhibition of tumor suppressor genes results in the acquisition of a cellular growth advantage, usually manifested as increased proliferation [1]. Many of the mechanisms that mediate these functions have been elucidated, while the function of others still remains to be resolved. Nevertheless, there exists a broad stratification of genes whose alteration is mechanistic in the development of neoplasia. By contrast, bcl-2, which was originally identified in 1984 [2], appears to function by a mechanism independent of the above two categories, and it may be the first described member of a third broad class of genes whose deregulation plays a role in oncogenesis. It appears to act by inhibiting cell death, rather than by stimulating proliferation.

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Authors
  1. Adam Bagg
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  2. Jeffrey Cossman
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  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher C. Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison T. Liu

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Bagg, A., Cossman, J. (1993). BCL-2: Physiology and role in neoplasia. In: Benz, C.C., Liu, E.T. (eds) Oncogenes and Tumor Suppressor Genes in Human Malignancies. Cancer Treatment and Research, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3088-6_7

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