Oncogenes and Tumor Suppressor Genes in Human Malignancies

1. Front Matter

   Pages i-xvii

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2. Oncogenes and tumor suppressor genes

   • Edison Liu, Bernard Weissman

   Pages 1-13

3. Activated oncogenes and putative tumor suppressor genes involved in human breast cancers

   • Debasish Tripathy, Christopher C. Benz

   Pages 15-60

4. Oncogenes in human lung cancer

   • Robert A. Kratzke, Eiji Shimizu, Frederic J. Kaye

   Pages 61-85

5. Thyroid growth factors and oncogenes

   • Orlo H. Clark, Quan-Yang Duh

   Pages 87-104

6. Growth regulation of human neuroblastoma

   • Osama M. El-Badry, Mark A. Israel

   Pages 105-128

7. Kaposi sarcoma: A cytokine-responsive neoplasia?

   • Steven A. Miles

   Pages 129-140

8. BCL-2: Physiology and role in neoplasia

   • Adam Bagg, Jeffrey Cossman

   Pages 141-166

9. Malignant transformation by abl and BCR/ABL

   • Richard A. Van Etten

   Pages 167-192

10. The biological and clinical roles of increased insulin receptors in human breast cancer

    • Riccardo Vigneri, Ira D. Goldfine

    Pages 193-209

11. The role of fibroblast growth factors and related oncogenes in tumor growth

    • Harold Brem, Michael Klagsbrun

    Pages 211-231

12. Transforming growth factor-alpha and its role in neoplastic progression

    • David C. Lee, Noreen C. Luetteke, Leslie A. Petch

    Pages 233-254

13. Growth regulation by transforming growth factor-β

    • Bradley A. Arrick, Rik Derynck

    Pages 255-264

14. Signal transduction by receptor tyrosine kinases

    • David R. Kaplan, Archibald Perkins, Deborah K. Morrison

    Pages 265-279

15. Involvement of G proteins, cytoplasmic calcium, phospholipases, phospholipid-derived second messengers, and protein kinases in signal transduction from mitogenic cell surface receptors

    • Roy A. Frye

    Pages 281-299

16. Fos and Jun: Inducible transcription factors regulating growth of normal and transformed cells

    • Jeffrey Holt

    Pages 301-311

17. DNA binding by the Myc oncoproteins

    • Gregory J. Kato, Daniel S. Wechsler, Chi V. Dang

    Pages 313-325

18. Normal and malignant growth control by p53

    • Cathy A. Finlay

    Pages 327-344

19. Nucleoside diphosphate kinases, nm23, and tumor metastasis: Possible biochemical mechanisms

    • Adam Golden, Mary Benedict, Allen Shearn, Narimichi Kimura, Alvaro Leone, Lance A. Liotta et al.

    Pages 345-358

20. Angiogenesis: A mechanism by which oncogenes and tumor suppressor genes regulate tumorigenesis

    • Noël Bouck

    Pages 359-371

The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage­ ment.

• DNA
• angiogenesis
• cell
• metastasis
• tumor
• tumorigenesis

• Cancer Research Institute, University of California, San Francisco, USA

  Christopher C. Benz

• Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

  Edison T. Liu

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