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Thyroid growth factors and oncogenes

  • Chapter
Oncogenes and Tumor Suppressor Genes in Human Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 63))

Abstract

Thyroid neoplasms and thyroid enlargement result from the preferential growth (benign), invasion, and/or metastases (malignant) of either follicular or parafollicular cells in the thyroid gland. By histological examination at autopsy and by sensitive localization procedures such as ultrasound, about 50% of persons have thyroid tumors [1,2]. Although most thyroid tumors are benign, thyroid cancer has been documented at postmortem examinations in 13% of person in Minnesota and up to 28% of Japanese in Hawaii [3,4]. Most of these tumors are occult and of little clinical consequence. Clinically appreciable enlarged thyroid glands, however, occur in about 4% of the population in the United States and are more common in areas of endemic goiter [5]. Diffuse and nodular hyperplasia of the thyroid gland with or without hyperfunction (hyperthyroidism) is also a relatively common clinical problem.

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Authors
  1. Orlo H. Clark
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  2. Quan-Yang Duh
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Editors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher C. Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison T. Liu

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Clark, O.H., Duh, QY. (1993). Thyroid growth factors and oncogenes. In: Benz, C.C., Liu, E.T. (eds) Oncogenes and Tumor Suppressor Genes in Human Malignancies. Cancer Treatment and Research, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3088-6_4

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