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Nucleoside diphosphate kinases, nm23, and tumor metastasis: Possible biochemical mechanisms

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Oncogenes and Tumor Suppressor Genes in Human Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 63))

Abstract

Tumor metastasis remains the leading cause of death for cancer patients, excluding those with skin cancers. Metastasis is a complex process, requiring tumor cell invasion, motility, arrest and extravasation from the circulatory system, angiogenesis, and avoidance of host immune responses. A considerable list of proteases, motility factors, and adhesion molecules for cells and extracellular matrix components have been examined for their potential roles in the tumor metastatic process [reviewed in 1,2].

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Authors
  1. Adam Golden
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  2. Mary Benedict
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  3. Allen Shearn
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  4. Narimichi Kimura
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  5. Alvaro Leone
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  6. Lance A. Liotta
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  7. Patricia S. Steeg
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Editor information

Editors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher C. Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison T. Liu

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© 1993 Springer Science+Business Media New York

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Golden, A. et al. (1993). Nucleoside diphosphate kinases, nm23, and tumor metastasis: Possible biochemical mechanisms. In: Benz, C.C., Liu, E.T. (eds) Oncogenes and Tumor Suppressor Genes in Human Malignancies. Cancer Treatment and Research, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3088-6_18

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  • DOI: https://doi.org/10.1007/978-1-4615-3088-6_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6349-1

  • Online ISBN: 978-1-4615-3088-6

  • eBook Packages: Springer Book Archive

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