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Transforming growth factor-alpha and its role in neoplastic progression

  • Chapter
Oncogenes and Tumor Suppressor Genes in Human Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 63))

Abstract

The discovery of transforming growth factor alpha (TGF-α) stemmed from a finding by Todaro et al. [1] in the mid-1970s that several retrovirally transformed cell lines showed reduced surface binding of radiolabeled EGF. This led to an examination of media conditioned by these cells for factors that would bind the EGF receptor, thereby making it unavailable to the exogenously added ligand. Such a factor was identified in media conditioned by feline sarcoma virus-transformed fibroblasts and was therefore named sarcoma growth factor (SGF) [2]. Subsequent studies showed that SGF-like activity could be identified in media conditioned by a variety of chemically and retrovirally transformed cells, but not by their normal cell counterparts [3–5]. This, in turn, stimulated the belief that the production of SGF contributed to the development and/or maintenance of the transformed phenotype.

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  1. David C. Lee
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  3. Leslie A. Petch
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  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher C. Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison T. Liu

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© 1993 Springer Science+Business Media New York

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Lee, D.C., Luetteke, N.C., Petch, L.A. (1993). Transforming growth factor-alpha and its role in neoplastic progression. In: Benz, C.C., Liu, E.T. (eds) Oncogenes and Tumor Suppressor Genes in Human Malignancies. Cancer Treatment and Research, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3088-6_11

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  • DOI: https://doi.org/10.1007/978-1-4615-3088-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6349-1

  • Online ISBN: 978-1-4615-3088-6

  • eBook Packages: Springer Book Archive

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