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Vascular Actions of Hypothermia in Brain Trauma

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Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

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Abstract

Traumatic brain injury (TBI) is a serious condition that affects approximately 1.5 million people in the United States each year. Currently, there are no approved therapies to treat the devastating consequences of severe TBI. Therapeutic hypothermia has a history of showing efficacy both in animal models and clinical studies. Potential mechanisms by which hypothermia may improve traumatic outcome include targeting vascular alterations such as by reducing the incidence of blood–brain barrier (BBB) permeability. In addition, therapeutic hypothermia promotes normal vascular reactivity and reduces a variety of inflammatory processes that are activated by trauma-induced cerebrovascular damage. Ongoing research in the laboratory and clinic is demonstrating that therapeutic hypothermia may indeed protect specific populations of severe TBI patients by targeting vascular perturbations including altered BBB function.

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Acknowledgements

The authors would like to thank Jeremy Lytle for his editorial assistance. This work was supported by grants NIH NS030291, NS042133, NS056072, and a Veterans Affairs grant BX000521.

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Authors and Affiliations

  1. Department of Neurological Surgery and Miami Project to Cure Paralysis, University of Miami, Leonard M. Miller School of Medicine, Lois Pope LIFE Center, 1095 NW 14th Terrace, Suite 2-30 (R48), Miami, FL, 33136-1060, USA

    W. Dalton Dietrich

  2. Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA

    Helen M. Bramlett

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  1. W. Dalton Dietrich
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  2. Helen M. Bramlett
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Correspondence to W. Dalton Dietrich .

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Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Dietrich, W.D., Bramlett, H.M. (2014). Vascular Actions of Hypothermia in Brain Trauma. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_12

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