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Intraoperative Optical Imaging

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Intraoperative Imaging and Image-Guided Therapy

Abstract

During surgery, disease is often detected by visual inspection alone. Inherently, surgical vision is limited however to superficial contrast. In addition, the human eye can recognize anatomical structures, but it is not able to detect molecular-based features. Human vision can be enhanced via the use of targeted and nontargeted fluorescent agents, which can reveal otherwise invisible disease biomarkers.

While the introduction of a new therapeutic agent into clinical use needs to undergo time- and cost-demanding processes, careful selection of lead candidates can shift the paradigm in surgical intervention. This chapter describes the development and applications of fluorescence imaging in surgery, including preclinical and clinical examples. We discuss clinical results employing targeted fluorochromes, which exemplify the potential of fluorescence molecular imaging in humans. A strategy to select best targets and facilitate clinical translation is discussed. Finally the broad possibilities and future perspectives of optical guided surgery using multispectral optoacoustic tomography (MOST) are described.

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Author information

Authors and Affiliations

  1. Department of Surgical Oncology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9700 RB, The Netherlands

    Niels J. Harlaar MD & Gooitzen M. van Dam MD, PhD

  2. Munich Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany

    Vasilis Ntziachristos PhD (Chair for Biological Imaging)

Authors
  1. Niels J. Harlaar MD
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  2. Gooitzen M. van Dam MD, PhD
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  3. Vasilis Ntziachristos PhD
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Corresponding author

Correspondence to Vasilis Ntziachristos PhD .

Editor information

Editors and Affiliations

  1. National Center for Image Guided Therapy, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Ferenc A. Jolesz

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Harlaar, N.J., van Dam, G.M., Ntziachristos, V. (2014). Intraoperative Optical Imaging. In: Jolesz, F. (eds) Intraoperative Imaging and Image-Guided Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7657-3_16

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  • DOI: https://doi.org/10.1007/978-1-4614-7657-3_16

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  • Print ISBN: 978-1-4614-7656-6

  • Online ISBN: 978-1-4614-7657-3

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