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The Role of GPR55 in Bone Biology

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endoCANNABINOIDS

Part of the book series: The Receptors ((REC,volume 24))

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Abstract

A novel and necessary role for GPR55 in bone physiology was demonstrated by Whyte et al. (Proc Natl Acad Sci 106(38):16551–16516, 2009). This chapter aims to summarise the work that became the first study to demonstrate a non-neuronal physiological role for GPR55 in vivo. In summary, male mice lacking GPR55 develop a high bone mass phenotype due to impairment in osteoclast function—consistent with GPR55 agonists O-1602 and LPI stimulating osteoclast function. These studies advocate the development of GPR55 antagonists for the treatment of diseases associated with excessive osteoclast activity such as osteoporosis.

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Authors and Affiliations

  1. Institute of Medical Sciences, University of Aberdeen, Foresterhill Campus, Aberdeen, Scotland, AB25 2ZD, UK

    Lauren S. Whyte

  2. Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK

    Ruth A. Ross

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  1. Lauren S. Whyte
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Correspondence to Lauren S. Whyte .

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Editors and Affiliations

  1. , Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, 19140, Pennsylvania, USA

    Mary E. Abood

  2. National Institutes of Health, Division of Basic Neuroscience and Behav, National Institute on Drug Abuse, 6001 Executive Blvd, Bethesda, 20892, Maryland, USA

    Roger G Sorensen

  3. , Pharmacology and Psychiatry and Behavior, University of Washington, Box 357280, Seattle, 98195, Washington, USA

    Nephi Stella

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Whyte, L.S., Ross, R.A. (2013). The Role of GPR55 in Bone Biology. In: Abood, M., Sorensen, R., Stella, N. (eds) endoCANNABINOIDS. The Receptors, vol 24. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4669-9_4

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