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The Role of Tumor Exosomes in Tumorigenicity

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Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication

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Abstract

Tumor growth and metastasis is dependent on a complex interplay between the tumor cells and the tumor stroma as well as tumor-tumor interaction. This communication occurs through direct interaction, secreted factors as well as microvesicles carrying proteins and nucleic acids. The tumor microvesicles carry a wide range of cargo, including oncogenic proteins, fragmented DNA, mRNA and non-coding RNA with regulatory functions that can be horizontallytransferred between different cells. In addition, these microvesicles are enriched in retrotransposable elements that have been implicated with genetic instability and transcriptional dysregulation.

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Author information

Authors and Affiliations

  1. James Brown Cancer Center, University of Louisville, CTRB 309 505 South, Hancock Street Louisville, 40202, Louisville, KY, USA

    Huang-Ge Zhang

  2. Exosome Diagnostics Inc., The Lasker Biomedical Research Building, 3960 Broadway, Suite 540, 10032, New York, NY, USA

    Johan K. O. Skog

Authors
  1. Huang-Ge Zhang
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  2. Johan K. O. Skog
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Editors and Affiliations

  1. , James Brown Cancer Center, University of Louisville, 505 S. Hancock Street, Louisville, 40202, Kentucky, USA

    Huang-Ge Zhang

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Zhang, HG., Skog, J. (2013). The Role of Tumor Exosomes in Tumorigenicity. In: Zhang, HG. (eds) Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3697-3_8

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