Abstract
Increasing evidences in the last years suggested a possible involvement of caveolin-1 (cav-1) in the biology of brain tumors. In vitro studies on glioma cell lines as well as immuno-phenotyping of primary human gliomas reported that cav-1 expression in brain tumors varies according to the histotype and grade, and could bear prognostic significance in specific tumor subsets. In addition, due to the described irradiation-dependent modulation of cav-1 expression in glioma cells and the presence of data highlighting heterogeneous trafficking dynamics involving the EGFR-cav-1 coupling in solid tumors, it can be envisaged that cav-1 could soon be taken into account in the perspective of novel therapeutic approaches for malignant brain tumors.
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Senetta, R., Cassoni, P. (2012). Caveolin-1 in Brain Tumors. In: Mercier, I., Jasmin, JF., Lisanti, M. (eds) Caveolins in Cancer Pathogenesis, Prevention and Therapy. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1001-0_4
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