Skip to main content
SpringerLink
Log in

Mitogenic Stimulation of Tumor Cells by Platelet Derived Growth Factors

  • Chapter
Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

There is evidence that platelets are involved in the hematogenous spread of malignant tumors. Certain tumor cells aggregate platelet in vitro (1–4) and an intimate relationship between platelets and tumor cells is further suggested by ultrastructural studies in vivo which show arrested tumor emboli surrounded by platelets (5–8). Certain tumor lines also induce thrombocytopenia in vivo (1,5,9). The reasons for this close platelet-tumor cell relationship are speculative at present. Possibilities include: 1) protection by platelets of the tumor cell against immune destruction, 2) enhanced tumor cell transit of the vascular endothelium via platelet adherence or 3) tumor cell survival and multiplication due to release of platelet mitogenic factors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gasic GJ, Gasic TB, Galanti N, Johnson T and Murphy S. Int. J. Cancer 11: 704–718, 1973.

    Article  PubMed  CAS  Google Scholar 

  2. Gasic GJ, Boettiger D, Catalfamo JL, Gasic TB and Stewart GJ. Cancer Res. 38: 2950–2955, 1977.

    Google Scholar 

  3. Marcum JM, McGill M, Bastida E, Ordinas A and Jamieson GA. J. Lab. Clin. Med. 96: 1046–1053, 1980.

    PubMed  CAS  Google Scholar 

  4. Pearlstein E, Cooper LB and Karpatkin S. J. Lab. Clin. Med. 93: 332–344, 1979.

    PubMed  CAS  Google Scholar 

  5. Hilgard P and Gordon-Smith EC. Br. J. Haematol. 26: 651–659, 1974.

    Article  PubMed  CAS  Google Scholar 

  6. Jones JD, Wallace AC and Fraser EF. J. Natl. Cancer Inst. 46: 493–504, 1971.

    PubMed  CAS  Google Scholar 

  7. Sindelar WF, Tralka TS and Ketcham AS. J. Surg. Res. 18: 137–161, 1975.

    Article  PubMed  CAS  Google Scholar 

  8. Warren BA and Vales O. Br. J. Exp. Pathol. 53: 301–313, 1972.

    CAS  Google Scholar 

  9. Hilgard P. Br. J. Cancer 28: 429–435, 1973.

    Article  PubMed  CAS  Google Scholar 

  10. Balk SD. Proc. Natl. Acad. Sci. USA 68: 271–276, 1971.

    Article  CAS  Google Scholar 

  11. Kohler N and Upton A. Exp. Cell Res. 87: 297–301, 1974.

    Article  PubMed  CAS  Google Scholar 

  12. Ross R, Glomset B, Kariya B and Harker L. Proc. Natl. Acad. Sci. USA 71: 1207–1210, 1974.

    Article  PubMed  CAS  Google Scholar 

  13. Rutherford RB and Ross R. J. Cell Biol. 69: 196–203, 1976.

    Article  PubMed  CAS  Google Scholar 

  14. Heldin C-H, Westermark B and Wasteson A. Proc. Natl. Acad. Sci. USA 78: 3664–3668, 1981.

    Article  PubMed  CAS  Google Scholar 

  15. Raines E and Ross R. J. Biol. Chem. 257: 5154–5160, 1982.

    CAS  Google Scholar 

  16. Deuel TF, Huang JS, Profitt RT, Baenziger JR, Change D and Kennedy BB. J. Biol. Chem. 256: 8896–8899, 1981.

    CAS  Google Scholar 

  17. Antoniades HN, Scher CD and Stiles CD. Proc. Natl. Acad. Sci. USA 76: 1809–1813, 1979.

    Article  PubMed  CAS  Google Scholar 

  18. Heldin CH, Westermark B and Wasteson A. J. Biol. Chem. 257: 4216–4221, 1982.

    CAS  Google Scholar 

  19. Bowen-Pope DF and Ross R. J. Biol. Chem. 257: 5161–5171, 1982.

    CAS  Google Scholar 

  20. Glenn KC, Bowen-Pope DF and Ross R. J. Biol. Chem. 257: 5172–5176, 1982.

    CAS  Google Scholar 

  21. Witte LD, Kaplan KL, Nossel HL, Lages BA, Weiss HJ and Goodman DS. Circ. Res. 42: 402–406, 1978.

    PubMed  CAS  Google Scholar 

  22. Kaplan KL, Broekman MJ, Chernoff A, Lesznik GR and Drillings M. Blood 53: 604–609, 1979.

    PubMed  CAS  Google Scholar 

  23. Chernoff A, Goodman DS and Levine RF. J. Clin. Invest. 65: 926–929, 1980.

    Article  PubMed  CAS  Google Scholar 

  24. Pledger W, Stiles C, Antoniades H and Scher C. Proc. Natl. Acad. Sci. USA 74: 2839–2845, 1978.

    Article  Google Scholar 

  25. Jennings T, Jones R and Upton A. J. Cell. Physiol. 100: 273–277, 1979.

    Article  CAS  Google Scholar 

  26. Vogel A, Raines E, Kariya B, Rivest M-J and Ross R. Proc. Natl. Acad. Sci. USA 75: 2810–2814, 1978.

    Article  PubMed  CAS  Google Scholar 

  27. Clemmons DR and Van Wyk JJ. J. Cell. Physiol. 106: 361–366, 1981.

    Article  PubMed  CAS  Google Scholar 

  28. Davies PF and Ross R. J. Cell Biol. 79: 663–671, 1978.

    Article  PubMed  CAS  Google Scholar 

  29. Habenicht A, Glomset JA, King WC, Nist C, Mitchell DC and Ross R. J. Biol. Chem. 256: 12329–12335, 1981.

    PubMed  CAS  Google Scholar 

  30. Grotendorst GR, Chang T, Seppa HEJ, Kleinman HK and Martin GR. J. Cell. Physiol. 113: 261–266, 1982.

    Article  PubMed  CAS  Google Scholar 

  31. Leitzel K, Cano C, Marks J and Lipton A. Manuscript submitted for publication.

    Google Scholar 

  32. Kepner N, Creasy G and Lipton A. In: Platelets: A Multidisciplinary Approach. (Eds. deGaetano G and Garattini S), Raven Press, New York, pp. 205–212, 1978.

    Google Scholar 

  33. Kepner N and Upton A. Cancer Res. 41: 430–432, 1981.

    PubMed  CAS  Google Scholar 

  34. Eastment CT and Sirbasku DA. J. Cell. Physiol. 97: 17–27, 1978.

    Article  PubMed  CAS  Google Scholar 

  35. Eastment CT and Sirbasku DA. In Vitro 16: 694–699, 1980.

    Article  PubMed  CAS  Google Scholar 

  36. Hara Y, Steiner M and Baldini MG. Cancer Res. 40: 1212–1216, 1980.

    PubMed  CAS  Google Scholar 

  37. Cowan DH and Graham J. In: Interaction of Platelets and Tumor Cells (Eds. Jamieson GA and Scipio AR), Alan R. Uss, Inc., New York, pp. 249–268, 1982.

    Google Scholar 

  38. Duff R and Rapp F. Nature (London) 233: 48–50, 1971.

    Article  CAS  Google Scholar 

  39. Duff R and Rapp F. J. Virol. 8: 469–477, 1971.

    PubMed  CAS  Google Scholar 

  40. Witkoski E, Kempner N, Leitzel K, Rogers C, Jefferson LS and Upton A. Cancer Res. 42: 2350–2352, 1982.

    PubMed  CAS  Google Scholar 

  41. Kahn P, Simon RS, Klein AS and Shin S. Cold Spring Harbor Symp. Quant. Biol. 44: 695–702, 1980.

    PubMed  Google Scholar 

  42. De Larco JE and Todaro GJ. Proc. Natl. Acad. Sci. USA 7 5: 4001–4005, 1978.

    Article  Google Scholar 

  43. Roberts AB, Lamb LC, Newton DL, Sporn MB and De Larco JE. Proc. Natl. Acad. Sci. USA 77: 3494–3498, 1980.

    Article  PubMed  CAS  Google Scholar 

  44. Todaro GJ, Fryling C and De Larco JE. Proc. Natl. Acad. Sci. USA 77: 5258–5262, 1980

    Article  PubMed  CAS  Google Scholar 

  45. Ozanne B, Fulton RJ and Kaplan PL. J. Cell. Physiol. 105: 163–180, 1980.

    Article  PubMed  CAS  Google Scholar 

  46. De Larco JE, Preston YA and Todaro GJ. J. Cell. Physiol. 109: 143–152, 1981.

    Article  PubMed  Google Scholar 

  47. Kaplan PL, Topp WC and Ozanne B. Proc. Natl. Acad. Sci. USA 79: 485–489, 1981.

    Article  Google Scholar 

  48. Kryceve-Martinerie C, Lawrence DA, Crochet J, Jullien P and Vigier P. J. Cell. Physiol. 113: 365–372, 1982.

    Article  CAS  Google Scholar 

  49. Moses HL, Branum EL, Proper JA and Robinson RA. Cancer Res. 41: 2842–2848, 1980.

    Google Scholar 

  50. Roberts AB, Anzano MA, Lamb LC, Smith JM and Sporn MB. Proc. Natl. Acad. Sci. USA 78: 5339–5343, 1981.

    Article  PubMed  CAS  Google Scholar 

  51. Sherwin SA, Twardzik ER, Bohn WH, Cockley KD and Todaro GJ. Cancer Res. 43: 403–407, 1983.

    PubMed  CAS  Google Scholar 

  52. Marquardt H and Todaro GJ. J. Biol. Chem. 257: 5220–5225, 1982.

    PubMed  CAS  Google Scholar 

  53. Roberts AB, Anzano MA, Lamb LC, Smith JM, Frolik CA, Marquardt H, Todaro GJ and Sporn MB. Nature (London) 295: 417–419, 1982.

    Article  CAS  Google Scholar 

  54. Gasic GJ, Gasic TB and Murphy S. Lancet 2: 932–933, 1977.

    Google Scholar 

  55. Gasic GJ, Gasic TB and Stewart CC. Proc. Natl. Acad. Sci. USA 61: 46–52, 1968.

    Article  PubMed  CAS  Google Scholar 

  56. Kolenich JJ, Mansour EG and Flynn A. Lancet 2: 932–933, 1977.

    Google Scholar 

  57. Wood S Jr. and Hilgard P. Lancet 2: 1416–1417, 1972.

    Article  PubMed  Google Scholar 

  58. Hilgard P, Heller H and Schmidt CG. Z. Krebsforsch. 86: 243–250, 1976.

    Article  CAS  Google Scholar 

  59. Astler VB and Coller FA. Ann. Surg. 139: 846–852, 1954.

    Article  PubMed  CAS  Google Scholar 

  60. Lipton A, Scialla S, Harvey H, Dixon R, Gordon R, Hamilton R, Ramsey H, Weltz M, Heckard R and White D. J. Med. 13: 419–429, 1982.

    PubMed  CAS  Google Scholar 

  61. Wu KK. J. Clin. Invest. 68: 382–387, 1981.

    Article  CAS  Google Scholar 

Download references

Authors
  1. Allan Lipton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cheryl Cano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kim Leitzel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Lipton, A., Cano, C., Leitzel, K. (1984). Mitogenic Stimulation of Tumor Cells by Platelet Derived Growth Factors. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation