Summary
Platelets were suggested to play a specific role in the haematogenous spread of experimental tumours. To test this hypothesis mice were treated with various inhibitors of platelet function (acetyl-salicylic acid, RA 233, ben-cyclan-, cyproheptadine). The effect of treatment on the development of lung colonies after i.v. tumour cell injection as well as on the formation of spontaneous metastases from the solid Lewis-lung carcinoma was evaluated. A significant increase of lung colonies after pretreatment with the platelet aggregation inhibitors was found. The effect of long term treatment on spontaneous metastasis formation gave equivocal results. The present investigations do not support the importance of the integrity of platelet function as a prerequisite for metastasis formation.
Zusammenfassung
Von verschiedenen Autoren wurde eine spezifische Rolle der Blutplättchen bei der hämatogenen Metastasierung angenommen. Zur Prüfung dieser Hypothese wurden Mäuse mit verschiedenen thrombocytenaktiven Pharmaka behandelt (Azetylsalicylsäure, RA 233, Benzyclan und Cyproheptadin), und der Effekt dieser Behandlung sowohl auf die Ausbildung von Lungenkolonien nach i.v. Tumorzellinjektion als auch auf die Spontanmetastasierung des Lewis-lung-Carcinoms wurde gemessen. Die Behandlung mit Plättchenaggregationshemmern führte zu einer signifikanten Zunahme der Lungenkolonien, während kein wesentlicher Einfluß auf die Spontanmetastasierung nachweisbar war. Die vorliegenden Ergebnisse sprechen nicht für eine pathogenetische Bedeutung der Thrombocyten bei der experimentellen Metastasierung.
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Supported by a grant from the ‚'Deutsche Forschungsgemeinschaft” (Hi 213/2).
Parts of the present paper are submitted by H.H. to the Faculty of Medicine (Essen) as M.D. thesis.
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Hilgard, P., Heller, H. & Schmidt, C.G. The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL). Z. Krebsforsch. 86, 243–250 (1976). https://doi.org/10.1007/BF00286943
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DOI: https://doi.org/10.1007/BF00286943