Abstract
It is quite obvious that foods contain large numbers of constituents, some of which are of little nutritive value for the consumer. Some components, however, not only lack nutritive value, but interfere with other constituents and reduce their nutritive value. They may, therefore, be termed antinutritive factors. The effects of such antinutrients can be manifold. In one situation, the substances interfere with the uptake or metabolism of certain nutrients, which may result in disturbances in the normal physiological function in man. The occurrence of certain oligosaccharides in some legumes may thus result in problems such as flatulence. Thyroid deficiency induced by glucosinolates occurring in plants of the genus Brassica, which interfere with the thyroid hormone production, is another example, where the antimetabolic effect is more pronounced. Toxicants produced by various microorganisms which induce intensive diarrhea, and the carcinogenic effect of certain mycotoxins are examples of more potent factors occurring in natural foods that have been contaminated in one or another way. The most potent toxicants of all are reported to occur as normal constituents in some mushrooms.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Allison, A. C., 1963, Danger of vitamin K to newborn, Lancet 1: 669.
Anonymous, 1961, Treatment of hypercholesterolemia with nicotinic acid, Nutr. Rev. 19: 325.
Anonymous, 1968, Present knowledge of naturally occurring toxicants in food, Nutr. Rev. 26: 129.
Arnon, S. S., Midura, T. E., Damus, K., Wood, R. M., and Chin, J., 1978, Intestinal infection and toxin production by Clostridium botulinum as one cause of sudden infant death syndrome, Lancet 1: 1273.
Bailey, A. V., Harris, J. A., Skau, E. L., and Kerr, T., 1966, Cyclopropenoid fatty acid content and fatty acid composition of crude oils from twentyfive varieties of cottonseed, J. Am. Oil Chem. Soc. 43: 107.
Bell, E. A., 1973, Aminonitriles and aminoacids not derived from proteins, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 153, National Academy of Sciences, Washington, D.C.
Barger, G., 1931, Ergot and Ergotism, Guerney and Jackson, London.
Billek, G., 1973, Veränderungen der Fette unter Fritierbedingungen und deren analytische Erfassung. Chemische Veränderungen der Fette beim Fritieren, Fette Scifen Anstrichm. 75: 582.
Blackwell, B., Marley, M., Price, J., and Taylor, D. 1967, Hypertensive interaction between monoamine oxidase inhibitors and foodstuffs, Br. J. Psychiatry 113: 349.
Blix, G., 1965, A study on the relation between total calories and single nutrients in Swedish food, Acta. Soc. Med. Ups. 70: 117.
Blythe, C., 1976, Problems of diet and affluence, Food Policy 1: 91.
Boctor, A. M., and Harper, E. E., 1968, Tyrosine toxicity in the rat: The effect of high intake of p–hydroxyphenylpyruvic acid and force-feeding high tyrosine diet, J. Nutr. 95: 535.
Bowman, D. E., 1945, Amylase inhibitor of navy beans, Science 102: 358.
Boyd, W., and Shapleigh, E., 1954, Specific precipitating activity of plants agglutinins (lectins), Science 119: 419.
Bull, L. B., Culvenor, C. C. J., and Dick, A. T., 1968, The Pyrrolizidine Alkaloids, North-Holland Pub., Amsterdam.
Christensson, D. D., Wall, J. S., Dimler, R. J., and Booth, A. N., 1968, Nutritionally unavailable niacin in corn. Isolation and biological activity, J. Agric. Food Chem. 16: 100.
Christopherson, B. O., Svaar, H., Langmark, F. T., Gumpen, S. A., and Norum, K. R., 1976, Rapeseed oil and hydrogenated marine oils in nutrition, Ambio 5: 169.
Colombo, J. P., 1971, Congenital disorders of the urea cycle and ammonia detoxication, Monographs on Pediatrics, Vol. 1, S. Karger, Basel.
Connor, W. E., and Connor, S. L., 1976, Sucrose and Carbohydrate, in: Present Knowledge in Nutrition, 4th ed., p. 33, Nutrition Foundation, New York.
Darby, W. J., and Hambraeus, L., 1978, Proposed nutritional guidelines for utilization of industrially produced nutrients, Nutr. Rev. 36: 65.
Deinzer, M. L., Thomson, P. A., Burgett, D. M., and Isaacson, D. L., 1977, Pyrrolizidine alkaloids: Their occurrence in honey from tansy ragworth (Senecio jacobaea L.), Science 195: 497.
DiGeorge, A. M., and Auerbach, V. H., 1960, Leucine-induced hypoglycemia. A review and speculations, Am. J. Med. Sci. 240: 792.
Doster, A. R., Mitchell, F. E., Farrell, R. L., and Wilson, B. J., 1978, The effect of 4-ipomeanol, a product from mold–damaged sweet potatoes, on the bovine lung, Vet. Pathol. 15: 367.
Eakin, R. E., Snell, E. E., and Williams, R. J., 1940, A constituent of raw egg white capable of inactivating biotin in vitro, J. Biol. Chem. 136: 801.
Engfeldt, B. (ed.), 1975, Morphological and biochemical effects of orally administered rapeseed oil on rat myocardium, Acta. Med. Scand. Suppl. 585.
Feeney, R. E., Means, G. E., and Bigler, J. C., 1969, Inhibition of human trypsin, plasmin, and thrombin by naturally occurring inhibitors of proteolytic enzymes, J. Biol. Chem. 244: 1957.
Fossum, K., and Whitaker, J. R., 1968, Ficin and papain inhibitor from chicken egg white, Arch. Biochem. Biophys. 125: 536.
Glass, R. L., Krick, T. P., Sand, D. M., Rahn, C. R., and Schlenk, H., 1975, Furanoid fatty acids from fish lipids, Lipids 10: 695.
Gopalan, C., and Rao, K. S. J., 1975, Pellagra and amino acid imbalance, Vitam. Horm. 33: 505.
Green, R. G., 1937, Chastek paralysis, Minn. Wildl. Dis. Inv. 3: 83.
Greer, M. A., 1962, The natural occurrence of goitrogenic agents, Rec. Progr. Horm. Res. 18: 197.
Gustafsson, J.-Å., 1980, personal communication.
Hambraeus, L., Hardell, L. I., Westphal, O., Lorentsson, R., and Hjorth, G., 1974, Argininosuccinic aciduria. Report of three cases and the effect of high and reduced protein intake on the clinical state, Acta Paediatr. Scand. 63: 525.
Harper, A. E., 1958, Balance and imbalance of amino acids, Ann. N. Y. Acad. Sci. 69: 1025.
Harper, A. E., 1964, Amino acid toxicities and imbalances, in: Mammalian Protein Metabolism (H. N. Munro and J. B. Allison, eds.), Vol. II, p. 87, Academic Press, New York.
Harper, A. E., 1973, Amino acids of nutritional importance, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 130, National Academy of Sciences, Washington, D.C.
Harper, A. E., and Rogers, O. E., 1965, Amino acid imbalance, Proc. Nutr. Soc. 24: 173.
Harper, A. E., Benevenga, N. J., and Wohlhueter, R. M., 1970, Effects of ingestion of disproportionate amounts of amino acids, Physiol. Rev. 50: 428.
Hawksworth, G., and Hill, M. J., 1971, The formation of nitrosamines by human intestinal bacteria, Biochem. J. Proc. 122: 28.
Hill, K. R., 1960, Discussion on seneciosis in man and animals, Proc. R. Soc. Med. 53: 281.
Herting, D. C., 1966, Perspective on vitamin E, Am. J. Clin. Nutr. 19: 210.
Hindhede, M., 1913, Studien über Eiweissminimum, Skand. Arch. Physiol. 30: 97.
Hites, B. D., Sandstedt, R. M., and Schaumburg, L., 1951, Study of proteolytic activity in wheat flour doughs and suspensions. II. A papain inhibitor in flour, Cereal Chem. 28: 1.
Hobbs, B. C., and Gilbert, R. J., 1978, Food Poisoning and Food Hygiene, 4th ed., E. Arnold, London.
Hodges, R. E., 1976, Ascorbic acid, in: Present Knowledge in Nutrition, 4th ed. p. 119, Nutrition Foundation, New York.
Horwith, M. K., 1962, Interrelations between vitamin E and polyunsaturated fatty acids in adult man, Vitam. Horm. 20: 541.
Horwitz, D., Lovenberg, W., Engelman, K., and Sjoerdsma, A., 1964, Monoamine oxidase inhibitors, tyramine and cheese, J. Am. Med. Assoc. 188: 1108.
Jaffé, W. G., 1973, Toxic proteins and peptides, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 106, National Academy of Sciences, Washington, D.C.
Johnson, J. D., Kertchner, N., and Simoons, F. J., 1974, Lactose malabsorption: Its biology and history, Adv. Pediatr. 1: 197.
Josefsson, E., 1967, Distribution of thioglucosides in different parts of Brassica plants, Phytochemistry 6: 1617.
Keeney, D. R., 1970, Nitrates in plants and waters, J. Milk Food Technol. 33: 425.
Keys, A. (ed.), 1970, Coronary heart disease in seven countries, Circulation Suppl. 1:61.
Kildeberg, P., 1964, Disturbances of hydrogen ion balance occurring in premature infants. II. Late metabolic acidoses, Acta Paediat. Scand. 53: 517.
King, R. A., 1949, Vitamin E therapy in Dupuytren’s contracture, J. Bone Jt. Surg. 31B: 443.
Kingsbury, J. M., 1964, Poisonous Plants of the United States and Canada, Prentice-Hall, Englewood Cliffs, New Jersey.
Klavins, J. V., and Peacocke, I. L., 1964, Pathology of amino acid excess. III. Effects of administration of excessive amounts of sulphur-containing amino acids: Methionine with equimolar amounts of glycine and arginine, Br. J. Exp. Pathol. 45: 533.
Kratzer, F. H., Williams, D. E., Marshall, B., and Davis, P. N., 1954, Some properties of the chick growth inhibitor in linseed oil meal, J Nutr. 52: 555.
Kwok, R. H., 1968, Chinese restaurant syndrome, N. Engl. J. Med. 278: 796.
Lamden, M. P., 1971, Dangers of massive vitamin C intake, N. Engl. J. Med. 284: 336.
Lea, C. H., 1962, The oxidative deterioriation of food lipids, in: Symposium on Foods: Lipids and their Oxidation. ( H. W. Schultz, ed.), p. 3, Avi Pub., Westport, Connecticut.
Learmonth, E. M., 1958, The influence of soya flour on bread doughs. III. The distribution of the papain–inhibiting factor in soya beans, J. Sci. Food Agric. 9: 269.
Lijinsky, W., and Epstein, S. S., 1968, Nitrosamines as environmental carcinogens, Nature (London) 225: 21.
Linneweh, F., Ehrlich, M., Graul, E. H., and Hundeshagen, H., 1963, Über den Aminosäurentransport bei Phenylketonuricher Oligophrenia, Klin. Wochenschr. 41: 253.
Lovenberg, W., 1973, Some vaso- and psychoactive substances in food: amines, stimulants, depressants, and hallucinogens, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 170, National Academy of Sciences, Washington, D. C.
Mikolajzac, K. I., Freidinger, R. M., Smith, C. R., Jr., and Wolff, I. A., 1968, Oxygenated fatty acids of oil from sunflower seeds after prolonged storage, Lipids 3: 489.
Nater, J. P., and Doeglas, H. M. G., 1970, Halibut liver poisoning in 11 fishermen, Acta Dermatol. 50: 109.
Neame, K. D., 1961, Phenylalanine as inhibitor of transport of amino acids in brain, Nature (London) 192: 173.
Nikkilä, E. A., 1974, Influence of dietary fructose and sucrose on serum triglycerides in hypertriglyceridaemia and diabetes, in: Sugars in Nutrition ( H. L. Sipple and K. W. McNutt, eds.), p. 439, Academic Press, New York.
Oberleas, D., 1973, Phytates, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 363, National Academy of Sciences, Washington, D.C.
Oké, O. L., 1969, Oxalic acid in plants and in nutrition, World Rev. Nutr. Diet 10: 262.
Orgell, W. H., 1963, Inhibition of human plasma Cholinesterase in vitro by alkaloids, glycosides, and other natural substances, Lloydia 26: 36.
Osborne, T. B., and Mendel, L. B., 1917, The use of soybean as food, J. Biol. Chem. 32: 369.
Patwardhan, V. N., and White, J. W., Jr., 1973, Problems associated with particular foods, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 477, National Academy of Sciences, Washington, D.C.
Poswillo, D. E., Sopher, D., and Mitchell, S., 1972, Experimental induction of foetal malnutrition with “blighted” potato: A preliminary report, Nature (London) 239: 462.
Pusztai, A., 1968, General properties of a protein inhibitor from the seeds of kidney bean, Eur. J. Biochem. 5: 252.
Reddy, B. S., Narisawa, T., Vukurich, D., Weisburger, J. H., and Wynder, E. L., 1976, Effect of quality and quantity of dietary fat and dimethylhydrazine in colon carcinogenesis in rats, Proc. Soc. Exp. Biol. Med. 151: 237.
Refsum, S., 1946, Heredopathia atactica polyneuritiformis, Acta Psychiatr. Scand. Suppl. 38: 9.
Renwick, J. H., 1972, Hypothesis Anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubes, Br. J. Prev. Soc. Med. 26: 67.
Roine, P., Uksila, E., Teir, H., and Rapola, J., 1960, Histopathological changes in rats and pigs fed rapeseed oil, Z. Ernährungswiss. 1: 118.
Rosenthal, G., 1971, Interaction of ascorbic acid and warfarin, J Am. Med. Assoc. 215: 1671.
Rühl, R., 1951, Beitrag zur Pathologie und Toxikologie des Solanins, Arch. Pharm. (Paris) 284: 67.
Salmon, W. D., 1958, The significance of amino acid imbalance in nutrition, Am. J. Clin. Nutr. 6: 487.
Sandström, B.-M., 1980, Zinc absorbtion from composite meal, Näringsforskn. 24: 110.
Schantz, E. J., Ghazarossian, V. E., Schnoes, H. K., Strong, F. M., Springer, J. P., Pezzanite, J. O., and Clardy, J., 1975, The structure of saxitonin, J. Am. Chem. Soc. 97: 1238.
Select Committee on Nutrition and Human Needs, U.S. Senate, 1977, Dietary Goals for the United States, 2nd ed., Government Printing Office, Washington, D.C.
Sen Gupta, A. K., 1972, Epoxy-triglycerides in soyabean oil, Chem. Ind. March 1972: 257.
Shank, R. C., and Magee, P. N., 1967, Similarities between the biochemical actions of cycasin and dimethylnitrosamine, Biochem. J. 105: 521.
Sidransky, H., and Baba, T., 1960, Chemical pathology of acute amino acid deficiencies. III. Morphological and biochemical changes in young rats fed valine or lysine-devoid diet, J Nutr. 70: 463.
Smaskevskii, N. D., 1966, A natural antivitamin of pantothenic acid, Chem. Abstr. 65: 2677e.
Smith, R. J., 1980, Nitrites: FDA beats a surprising retreat, Science 209: 1100.
Somogyi, J. C., 1978, Natural toxic substances in food, in: Foreign Substances and Nutrition (J. C. Somogyi and R. Tarjan, eds.), Wld. Rev. Nutr. Diet 29: 42.
Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S., 1978, The Metabolic Basis of Inherited Disease, 4th ed., McGraw-Hill Book Co., New York.
Stansby, M. E., 1967, Fish Oils: Their Chemistry, Technology, Stability, Nutritional Properties and Uses, Avi Pub., Westport, Connecticut.
Steggerda, F. R., 1968, Gastrointestinal gas following food consumption, Ann. N. Y. Acad. Sci. 150: 57.
Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., and Bruce, W. R., 1978, Nitrite and nitrate are formed by endogenous synthesis in the human intestine, Science 200: 1487.
Truswell, A. S., 1978, Diet and plasma lipids: A reappraisal, Am. J. Clin. Nutr. 31: 977.
Vergroesen, A. J. (ed.), 1975, The Role of Fats in Human Nutrition, Academic Press, New York.
Virtanen, A. I., Kreula, M., and Kiesvaara, M., 1963, Investigations on the alleged goitrogenic properties of cow’s milk, Z. Emaehrungswiss. Suppl. 3: 23.
Whitaker, J. R., and Feeney, R. E., 1973, Enzyme inhibitors in foods, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 276, National Academy of Sciences, Washington, D.C.
Wilson, B. J., 1978, Hazards of mycotoxins to public health, J Food Prot. 41: 375.
Wilson, B. J., 1979, Naturally occurring toxicants in foods, Nutr. Rev. 37:305.
Wilson, B. J., and Hayes, A. W., 1973, Microbial toxins, in: Toxicants Occurring Naturally in Foods, 2nd ed., p. 372, National Academy of Sciences, Washington, D.C.
Wilson, B. J., Hoekman, T., and Dettbarn, W. D., 1972, Effects of a fungus tremorgenic toxin (ipenitrem A) on transmission in rat phrenic nerve-diaphragm preparations, Brain Res. 40: 540.
World Health Organization, 1972, Evaluation of certain food additives and the contaminants mercury, lead and cadmium, W. H. O. Tech. Rep. Ser. No. 505.
Wretlind, A., Truswell, A. S., Hejda, S., Isaksson, B., Kübler, W., and Vivanco, F., 1976, Round table on comparison of dietary recommendations in different European countries, Nutr. Metab. 21: 210.
Yudkin, J., and Morland, J., 1967, Sugar intake and myocardial infarction, Am. J. Clin. Nutr. 20: 503.
Ziemlanski, S., 1977, Pathophysiological effects of long-chain fatty acids, Bibl. Nutr. Dieta 25: 134.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Hambraeus, L. (1982). Naturally Occurring Toxicants in Food. In: Jelliffe, E.F.P., Jelliffe, D.B. (eds) Adverse Effects of Foods. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3359-3_2
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3359-3_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3361-6
Online ISBN: 978-1-4613-3359-3
eBook Packages: Springer Book Archive