Abstract
The search for an adequate treatment of major depression is one of the main challenges of Neuropharmacology. To date, no single drug is effective in all patients treated, probably due to the heterogeneity of the disease and to individual differences in the response to the agents used. Despite provoking pharmacological effects when given at once, all treatments need to be administered for several weeks before amelioration signs begin to emerge. This has led to the notion that —rather than the inhibition of uptake or monoamine oxidase (MAO) activity per se— adaptative changes of aminergic receptors mediate the clinical effects.
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© 1996 Plenum Press, New York
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Artigas, F., Bel, N., Casanovas, J.M., Romero, L. (1996). Adaptative Changes of the Serotonergic System After Antidepressant Treatments. In: Filippini, G.A., Costa, C.V.L., Bertazzo, A. (eds) Recent Advances in Tryptophan Research. Advances in Experimental Medicine and Biology, vol 398. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0381-7_6
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