Summary
The very active metabolic pathway for phosphatidic acid and phosphoinositides of the retina is affected greatly by the amphiphilic cation, propranolol. Propranolol, in addition to stimulating the synthesis of components of this pathway, also stimulates polyphosphoinositide degradation, probably due to the activation of a phospholipase C. Hence, propranolol stimulates the phosphoinositide cycle. This effect may be induced by a membrane perturbation caused by intercalation of the hydrophobic moiety of the drug in a membrane domain containing the components of the cycle. Exogenously added myo-inositol stimulates the synthesis of phosphatidylinositol and inhibits the propranolol-induced degradation of polyphosphoinositides suggesting that myo-inositol may modulate phosphoinositide metabolism. The use of propranolol as an experimental probe and the manipulation of phosphoinositide pathways by myo-inositol will prove useful in the study of the metabolism and function of phosphoinositides.
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References
Abdel-Latif, A.A., Smith, J.P. and Akhtar, R.A. (1983) Biochem. Pharmacol. 32, 3815–3821.
Anderson, R.E. and Hollyfield, J.G. (1981) Biochim. Biophys. Acta 665, 619–622.
Anderson, R.E., Maude, M.B. and Kelleher, P.A. (1980) Biochim. Biophys. Acta 620, 236–246.
Aveldano, M.I. and Bazan, N.G. (1983) J. Lipid Res. 24, 620–627.
Aveldano de Caldironi, M.I. and Bazan, N.G. (1979) Neurochem. Res. 4, 213–221.
Bazan, N.G. (1978) in: “Cyclitols and Phosphoinositides” (W. Wells and F. Eisenberg, eds.) pp. 563–568, Academic Press, New York.
Bazan, N.G. (1982) Vis. Res. 22, 1539–1548.
Bazan, N.G. (1983) Handbook of Neurochemistry 3, 17–39.
Bazan, H.E.P. and Bazan, N.G. (1976) J. Neurochem. 27, 1051–1057.
Bazan, H.E.P. and Bazan, N.G. (1977) Adv. Exp. Med. Biol. 83, 489–495.
Bazan, N.G., Aveldano, M.I., Bazan, H.E.P. and Giusto, N.M. (1976a) in: “Lipids” Vol. 1 (R. Paoletti, G. Porcellati and G. Jacini, eds.) pp. 89–97, Raven Press, New York.
Bazan, N.G., Ilincheta de Boschero, M.G., Giusto, N.M. and Bazan, H.E.P. (1976b) Adv. Exp. Med. Biol. 72, 139–148.
Bazan, N.G., Ilincheta de Boschero, M.G. and Giusto, N.M. (1977) Adv. Exp. Med. Biol. 83, 377–388.
Bazan, H.E.P., Careaga, M.M. and Bazan, N.G. (1981a) Biochim. Biophys. Acta 666, 63–71.
Bazan, N.G., Aveldano de Caldironi, M.I. and Rodriguez de Turco, E.B. (1981b) Progress in Lipid Res. 20, 523–529.
Bazan, N.G., di Fazio de Escalante, M.S., Careaga, N.M., Bazan, H.E.P. and Giusto, N.M. (1982a) Biochim. Biophys. Acta 712, 702–706.
Bazan, N.G., Morelli de Liberti, S.M. and Rodriguez de Turco, E.B. (1982b) Neurochem. Res. 7, 839–843.
Bleasdale, J.E., Maberry, M.C., Quirk, J.G. (1982) Biochem. J. 206, 43–52.
Brindley, D.N. and Bowley, M. (1975) Biochem. J. 148, 461–469.
Careaga, N.M. and Bazan, H.E.P. (1981) Neurochem. Res. 6, 1169–1178.
Daum, G., and Kohlwein, S.D., Zinser, E. and Paltauf, F. (1983) Biochim. Biophys. Acta 753, 430–438.
Eichberg, J., Gates, J. and Hauser, G. (1979) Biochim. Biophys. Acta 573, 90–106.
Esko, J.D. and Raetz, C.R.H. (1980) J. Biol. Chem. 255, 4474–4480.
Farese, R.V. (1983) Metabolism 32, 628–641.
Freinkel, N., Younsi, C., Dawson, R.M.C. (1975) Eur. J. Biochem. 59, 245–252.
Giusto, N.M. and Bazan, N.G. (1979) Exp. Eye Res. 29, 155–168.
Giusto, N.M., Ilincheta de Boschero, M.G. and Bazan, N.G. (1983) J. Neurochem. 40, 563–568.
Gonzalez-Sastre, F., Eichberg, J. and Hauser, G. (1971) Biochim. Biophys. Acta 248, 96–104.
Hallman, M. and Epstein, B.L. (1980) Biochem. Biophys. Res. Comm. 92, 1151–1159.
Hauser, G. and Eichberg, J. (1975) J. Biol. Chem. 250, 105–112.
Ilincheta de Boschero, M.G. and Bazan, N.G. (1982) Biochem. Pharmacol. 31, 1049–1055.
Ilincheta de Boschero, M.G. and Bazan, N.G. (1983) J. Neurochem. 40, 260–266.
Michell, R.H., Allan, D., Bowley, M. and Brindley, D.N. (1976) J. Pharm. Pharmacol. 28, 331–332.
Pappu, A.S., and Hauser, G. (1981) Biochem. Pharmacol. 30, 3243–3246.
Porzig, H. (1975) J. Physiol. 249, 27–49.
Quirk, J.G., Jr. and Bleasdale, J.E. (1983) Obstet. Gynecol. 62, 41–44.
Rodriguez de Turco, E.B., Morelli de Liberti, S.M., and Bazan, N.G. (1983) J. Neurochem. 40, 252–259.
Schmidt, S.Y. (1983a) J. Biol. Chem. 258, 6863–6868.
Schmidt, S.Y. (1983b) J. Neurochem. 40, 1630–1638.
Sturton, G.R., and Brindley, D.N. (1980) Biochim. Biophys. Acta 619, 494–505.
Yamashita S., and Oshima, A. (1980) Eur. J. Biochem. 104, 611–616.
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Bazan, N.G., Roccamo de Fernandez, A.M., Giusto, N.M., Ilincheta de Boschero, M.G. (1985). Propranolol-Induced Membrane Perturbation and the Metabolism of Phosphoinositides and Arachidonoyl Diacylglycerols in the Retina. In: Bleasdale, J.E., Eichberg, J., Hauser, G. (eds) Inositol and Phosphoinositides. Experimental Biology and Medicine, vol 6. Humana Press. https://doi.org/10.1007/978-1-4612-5184-2_5
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DOI: https://doi.org/10.1007/978-1-4612-5184-2_5
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