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Potential Regulators of Physiological Cell Death in the Corpus Luteum

  • Chapter
Cell Death in Reproductive Physiology

Part of the book series: Proceedings in the Serono Symposia USA Series ((SERONOSYMP))

Abstract

The corpus luteum (CL) is formed within the mammalian ovary from the remaining follicular tissue following ovulation of the dominant follicle(s). The primary function of the CL is to synthesize and secrete progesterone. Circulating levels of progesterone rise during luteinization of the ovulated follicle and are maintained in order to provide uterine quiescence for the establishment and maintenance of pregnancy. If, however, fertilization fails or does not occur, the CL regresses by a process referred to as luteolysis. The CL, like most female reproductive endocrine tissues, goes through a phase of rapid cellular growth, proliferation and neovascularization that, by many criteria, is analogous to tumor development. Unlike a tumor, however, the lifespan of the luteal cells is defined as removal of the CL is important for resumption of the next estrous or menstrual cycle. As would be expected, luteal regression is likely mediated via apoptosis. Although much is known about CL function, relatively little is known about mechanisms that regulate luteal cell death. Recently, there has been a plethora of information published regarding the role of reactive oxygen species (ROS), protooncogenes, tumor suppressor genes, transcription factors and proteases in regulating the fate of many cell types. The focus of this review is to discuss the potential role of oxidative stress response and cell death genes in regulating the lifespan of the CL. A brief review of the morphological and physiological aspects of luteal function and regression is also presented.

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Authors
  1. Bo R. Rueda
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  2. Debora L. Hamernik
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  3. Patricia B. Hoyer
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  4. Jonathan L. Tilly
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Editor information

Editors and Affiliations

  1. Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, 02114, USA

    Jonathan L. Tilly Ph.D.

  2. Center for Research on Reproduction and Women’s Health, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Jerome F. Strauss III M.D., Ph.D.

  3. W. Alton Jones Cell Science Center, Lake Placid, NY, 12946, USA

    Martin Tenniswood Ph.D.

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Rueda, B.R., Hamernik, D.L., Hoyer, P.B., Tilly, J.L. (1997). Potential Regulators of Physiological Cell Death in the Corpus Luteum. In: Tilly, J.L., Strauss, J.F., Tenniswood, M. (eds) Cell Death in Reproductive Physiology. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1944-6_14

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  • DOI: https://doi.org/10.1007/978-1-4612-1944-6_14

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