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Basic Physiology of Ion Channel Function

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Electrical Diseases of the Heart

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Abstract

The present chapter aims to provide the clinical cardiologist specialized in arrhythmias with the bare essentials regarding ion channel function and mechanisms of arrhythmias either acquired or inherited and the fundamentals of antiarrhythmic drug therapy. In cardiac electrophysiology, there is a continuum of concepts between the function of ion channel molecules and the clinical phenotype. The basic principles of cardiac electrophysiology: from ion channels to ion currents, action potentials and EKG are discussed. Tightly controlled cardiac electrical activity depends on specialized properties of nodal, atrial, ventricular and Purkinje tissues and cells. This chapter reviews the identified molecular actors of the cardiac electrical activity, focusing on regional contributions and differences.

Denis Escande is deceased.

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Authors and Affiliations

  1. Cardiopathies and Sudden Death, l’institut du thorax, INSERM UMR1087, CNRS UMR6291, IRS-UN, 8 quai Moncousu, 70721, 44007, Nantes, France

    Isabelle Baró PhD

  2. l’institut du thorax, Nantes, France

    Denis Escande MD, PhD

  3. Renovascular Physiopathology, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR6097, Université de Nice-Sophia Antipolis, 660 route des Lucioles, Sophia Antipolis, 06560, Valbonne, France

    Sophie Demolombe PhD

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  1. Isabelle Baró PhD
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  2. Denis Escande MD, PhD
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  1. , Department of Internal Medicine, UMDNJ-RWJ Medical School, Robert Wood Johnson Pl. 1, New Brunswick, 08903-0019, New Jersey, USA

    Ihor Gussak

  2. , Gordon K. Moe Scholar, Masonic Medical Research Laboratory, Bleecker Street, Utica, 13501-1787, New York, USA

    Charles Antzelevitch

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Baró, I., Escande, D., Demolombe, S. (2013). Basic Physiology of Ion Channel Function. In: Gussak, I., Antzelevitch, C. (eds) Electrical Diseases of the Heart. Springer, London. https://doi.org/10.1007/978-1-4471-4881-4_2

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