Abstract
Across the world, from 15 to 68 % of patients with stone may have a family history of stone in their first-degree relatives. A family history is associated with an earlier onset of disease and a greater chance of recurrence. The lifetime risk (to age 75) for a brother of the propositi is ∼50 %. The reason for a high frequency of stone in the immediate family might be consanguinity, dietary, or environmental. If genetic factors are present, the inheritance appears polygenetic rather than monogenetic.
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Talati, J.J., Haroon, N., Trinchieri, A. (2012). Familial Clustering of Stone Disease. In: Talati, J., Tiselius, HG., Albala, D., YE, Z. (eds) Urolithiasis. Springer, London. https://doi.org/10.1007/978-1-4471-4387-1_17
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