Abstract
Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population. Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney–ureter–bladder (KUB) and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members (21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (λR) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about 88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated with the disease.
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Acknowledgments
This work was financially supported by grants from the Faculty of Medicine Siriraj Hospital (to S. S.), the National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA) (to P. Y.), and Mahidol University (to P. Y.). We thank the patients and their families for participation in this project, the staff members of the Department of Medicine, Khon Kaen Hospital for their helps in logistics and field studies, the staff members of the Division of Nephrology, Department of Medicine Siriraj Hospital, Mahidol University for their assistances in laboratory works, and Ms. Ratree Tavichakorntrakool for her helps in parts of clinical studies and sample collection. P. Y. is a Senior Research Scholar of Thailand Research Fund (TRF).
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Sritippayawan, S., Borvornpadungkitti, S., Paemanee, A. et al. Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population. Urol Res 37, 141–146 (2009). https://doi.org/10.1007/s00240-009-0189-1
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DOI: https://doi.org/10.1007/s00240-009-0189-1