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Fertility Preservation

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In Vitro Fertilization

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Abstract

Several options are currently available for the preservation of fertility: embryo cryopreservation, oocyte cryopreservation, and ovarian tissue cryopreservation. The choice of the most suitable strategy for preserving fertility depends on different parameters: the indication, the type and timing of gonadotoxic treatment, the patient’s age, and the partner status. In this chapter, the different fertility preservation methods, their limitations and efficacy are reviewed.

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References

  1. Donnez J, Martinez-Madrid B, Jadoul P, Van Langendonckt A, Demylle D, Dolmans MM. Ovarian tissue cryopreservation and transplantation: a review. Hum Reprod Update. 2006;12:519–35.

    Article  PubMed  Google Scholar 

  2. Meirow D, Lewis H, Nugent D, Epstein M. Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool. Hum Reprod. 1999;14:1903–7.

    Article  PubMed  CAS  Google Scholar 

  3. Larsen EC, Muller J, Schmiegelow K, Rechnitzer C, Andersen AN. Reduced ovarian function in long-term survivors of radiation- and chemotherapy treated childhood cancer. J Clin Endocrinol Metab. 2003;88: 5307–14.

    Article  PubMed  CAS  Google Scholar 

  4. Shalet SM. Effects of cancer chemotherapy on gonadal function of patients. Cancer Treat Rev. 1980;7: 141–52.

    Article  PubMed  CAS  Google Scholar 

  5. Schilsky RL, Sherins RJ, Hubbard SM, Wesley MN, Young RC, DeVita VT. Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin’s disease. Am J Med. 1981;71:552–6.

    Article  PubMed  CAS  Google Scholar 

  6. Familiari G, Caggiati A, Nottola SA, Ermimi M, di Benedetto MR, Motta PM. Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin’s disease. Hum Reprod. 1993;8(12):2080–7.

    PubMed  CAS  Google Scholar 

  7. Meirow D, Dor J, Kaufman B, Shrim A, Rabinovici J, Schiff E, Raanani H, Levron J, Fridman E. Cortical fibrosis and blood-vessels damage in human ovaries exposed to chemotherapy. Potential mechanisms of ovarian injury. Hum Reprod. 2007;22(6):1626–33.

    Article  PubMed  CAS  Google Scholar 

  8. Wallace WH, Thomson AB, Saran F, Kelsey TW. Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys. 2005;62:738–44.

    Article  PubMed  Google Scholar 

  9. Carter A, Robison LL, Francisco L, Smith D, Grant M, Baker KS, Gurney JG, McGlave PB, Weisdorf DJ, Forman SJ, Bhatia S. Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the Bone Marrow Transplant Survivor Study. Bone Marrow Transplant. 2006; 37:1023–9.

    Article  PubMed  CAS  Google Scholar 

  10. Loren AW, Chow E, Jacobsohn DA, Gilleece M, Halter J, Joshi S, Wang Z, Sobocinski KA, Gupta V, Hale GA, Marks DI, Stadtmauer EA, Apperley J, Cahn JY, Schouten HC, Lazarus HM, Savani BN, McCarthy PL, Jakubowski AA, Kamani NR, Hayes-Lattin B, Maziarz RT, Warwick AB, Sorror ML, Bolwell BJ, Socié G, Wingard JR, Rizzo JD, Majhail NS. Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR). Biol Blood Marrow Transplant. 2011;17:157–66.

    Article  PubMed  Google Scholar 

  11. Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P, Van Lint MT, Powles R, Jackson G, Hinterberger-Fischer M, Kolb HJ, Apperley JF, Late Effects Working Party of the European Group for Blood and Marrow Transplantation. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet. 2001; 358:271–6.

    Article  PubMed  CAS  Google Scholar 

  12. Sanders JE, Hawley J, Levy W, Gooley T, Buckner CD, Deeg HJ, Doney K, Storb R, Sullivan K, Witherspoon R, Appelbaum FR. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood. 1996;87:3045–52.

    PubMed  CAS  Google Scholar 

  13. Wallace WHB, Thomson AB, Kelsey TW. The radiosensitivity of the human oocyte. Hum Reprod. 2003;18:117–21.

    Article  PubMed  CAS  Google Scholar 

  14. Critchley HO, Wallace WHB, Shalet SM, Mamtora H, Higginson J, Anderson DC. Abdominal irradiation in childhood; the potential for pregnancy. Br J Obstet Gynaecol. 1992;99:392–4.

    Article  PubMed  CAS  Google Scholar 

  15. Bath LE, Wallace WH, Critchley HO. Late effects of the treatment of childhood cancer on the female reproductive system and the potential for fertility preservation. Br J Obstet Gynaecol. 2002;109:107–14.

    Article  Google Scholar 

  16. Saenger P, Wikland KA, Conway GS, Davenport M, Gravholt CH, Hintz R, Hovatta O, Hultcrantz M, Landin-Wilhelmsen K, Lin A, et al. Fifth International Symposium on Turner Syndrome. Recommendations for the diagnosis and management of Turner syndrome. J Clin Endocrinol Metab. 2001;86:3061–9.

    Article  PubMed  CAS  Google Scholar 

  17. Pasquino AM, Passeri F, Pucarelli I, Segni M, Municchi G. Spontaneous pubertal development in Turner’s syndrome. Italian Study Group for Turner’s Syndrome. J Clin Endocrinol Metab. 1997;82: 1810–3.

    Article  PubMed  CAS  Google Scholar 

  18. Borgström B, Hreinsson J, Rasmussen C, Sheikhi M, Fried G, Keros V, Fridström M, Hovatta O. Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles. J Clin Endocrinol Metab. 2009;94:74–80.

    PubMed  Google Scholar 

  19. Oktay K, Oktem O. Fertility preservation medicine: A new field in the care of young cancer survivors. Pediatr Blood Cancer. 2009;53(2):267–73.

    Article  PubMed  Google Scholar 

  20. Longhi A, Pignotti E, Versari M, Asta S, Bacci G. Effect of oral contraceptive on ovarian function in young females undergoing neoadjuvant chemotherapy treatment for osteosarcoma. Oncol Rep. 2003;10(1):151–5.

    PubMed  Google Scholar 

  21. van der Kaaij MA, van Echten-Arends J, Simons AH, Kluin-Nelemans HC. Fertility preservation after chemotherapy for Hodgkin lymphoma. Hematol Oncol. 2010;28(4):168–79.

    Article  PubMed  Google Scholar 

  22. Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG. The effect of combination chemotherapy on ovarian function in women treated for Hodgkin’s disease. Cancer. 1983;52(6):988–93.

    Article  PubMed  CAS  Google Scholar 

  23. Bedaiwy MA, Abou-Setta AM, Desai N, Hurd W, Starks D, El-Nashar SA, Al-Inany HG, Falcone T. Gonadotropin-releasing hormone analog cotreatment for preservation of ovarian function during gonadotoxic chemotherapy: a systematic review and meta-analysis. Fertil Steril. 2011;95(3):906–14.

    Article  PubMed  CAS  Google Scholar 

  24. Ben-Aharon I, Gafter-Gvili A, Leibovici L, Stemmer SM. Pharmacological interventions for fertility preservation during chemotherapy: a systematic review and meta-analysis. Breast Cancer Res Treat. 2010;122(3):803–11.

    Article  PubMed  Google Scholar 

  25. Clowse ME, Behera MA, Anders CK, Copland S, Coffman CJ, Leppert PC, Bastian LA. Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis. J Womens Health (Larchmt). 2009;18(3):311–9.

    Article  Google Scholar 

  26. Kim SS, Lee JR, Jee BC, Suh CS, Kim SH, Ting A, Petroff B. Use of hormonal protection for chemotherapy-induced gonadotoxicity. Clin Obstet Gynecol. 2010;53(4):740–52.

    Article  PubMed  CAS  Google Scholar 

  27. Badawy A, Elnashar A, El-Ashry M, Shahat M. Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study. Fertil Steril. 2009;91(3):694–7.

    Article  PubMed  CAS  Google Scholar 

  28. del Mastro L, Boni L, Michelotti A, Gamucci T, Olmeo N, Gori S, Giordano M, Garrone O, Pronzato P, Bighin C, Levaggi A, Giraudi S, Cresti N, Magnolfi E, Scotto T, Vecchio C, Venturini M. Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomised trial. J Am Med Assoc. 2011;30(3):269–76.

    Article  Google Scholar 

  29. Sverrisdottir A, Nystedt M, Johansson H, Fornander T. Adjuvant goserelin and ovarian preservation in chemotherapy treated patients with early breast cancer: results from a randomized trial. Breast Cancer Res Treat. 2009;117(3):561–7.

    Article  PubMed  CAS  Google Scholar 

  30. Behringer K, Wildt L, Mueller H, Mattle V, Ganitis P, van den Hoonaard B, Ott HW, Hofer S, Pluetschow A, Diehl V, Engert A, Borchmann P, German Hodgkin Study Group. No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group. Ann Oncol. 2010;21(10): 2052–60.

    Article  PubMed  CAS  Google Scholar 

  31. Gerber B, von Minckwitz C, Stehle H, Reimer T, Felberbaum R, Maass N, Fischer D, Sommer HL, Conrad B, Ortmann O, Fehm T, Rezai M, Mehta K, Loibl S, German Breast Group Investigators. Effect of luteinizing hormone-releasing hormone agonist on ovarian function after modern adjuvant breast cancer chemotherapy: the GBG 37 ZORO study. J Clin Oncol. 2011;29(17):2334–41.

    Article  PubMed  CAS  Google Scholar 

  32. Morita Y, Perez I, Perez F, Miranda S, Ehleiter D, Haimovitz-Friedman A, Fuks Z, Xie Z, Reed JC, Schuchman EH, Kolesnick RN, Tilly JL. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine 1-phosphate therapy. Nat Med. 2000;6(10):1109–14.

    Article  PubMed  CAS  Google Scholar 

  33. Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick R. Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med. 2002;8(9):901–2.

    Article  PubMed  CAS  Google Scholar 

  34. Carmely A, Meirow D, Perets A, Albeck M, Bartoov B, Sredni B. Protective effect of the immunomodulator AS101 against cyclophosphamide-induced testicular damage in mice. Hum Reprod. 2009;24(6):1322–9. Epub 2009 Feb 24.

    Article  PubMed  Google Scholar 

  35. Ata B, Chian RC, Tan SL. Cryopreservation of oocytes and embryos for fertility preservation for female cancer patients. Best Pract Res Clin Obstet Gynaecol. 2010;24(1):101–12.

    Article  PubMed  Google Scholar 

  36. Nyboe Andersen A, Goossens V, Bhattacharya S, Ferraretti AP, Kupka MS, de Mouzon J, Nygren KG, European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod. 2009;24(6):1267–87.

    Google Scholar 

  37. Das M, Shehata F, Moria A, Holzer H, Son WY, Tulandi T. Ovarian reserve, response to gonadotropins, and oocyte maturity in women with malignancy. Fertil Steril. 2011;96(1):122–5.

    Article  PubMed  CAS  Google Scholar 

  38. Knopman JM, Noyes N, Talebian S, Krey LC, Grifo JA, Licciardi F. Women with cancer undergoing ART for fertility preservation: a cohort study of their response to exogenous gonadotropins. Fertil Steril. 2009;91(4 Suppl):1476–8.

    Article  PubMed  Google Scholar 

  39. Robertson AD, Missmer SA, Ginsburg ES. Embryo yield after in vitro fertilization in women undergoing embryo banking for fertility preservation before chemotherapy. Fertil Steril. 2011;95(2):588–91.

    Article  PubMed  Google Scholar 

  40. Quintero RB, Helmer A, Huang JQ, Westphal LM. Ovarian stimulation for fertility preservation in patients with cancer. Fertil Steril. 2010;93(3):865–8.

    Article  PubMed  CAS  Google Scholar 

  41. Friedler S, Koc O, Gidoni Y, Raziel A, Ron-El R. Ovarian response to stimulation for fertility preservation in women with malignant disease: a systematic review and meta-analysis. Fertil Steril. 2012;97(1): 125–33.

    Article  PubMed  Google Scholar 

  42. Anderson RA, Wallace WH. Fertility preservation in girls and young women. Clin Endocrinol (Oxf). 2011;75(4):409–19.

    Article  Google Scholar 

  43. Leader A, Lishner M, Michaeli J, Revel A. Fertility considerations and preservation in haemato-oncology patients undergoing treatment. Br J Haematol. 2011;153(3):291–308.

    Article  PubMed  Google Scholar 

  44. von Wolff M, Montag M, Dittrich R, Denschlag D, Nawroth F, Lawrenz B. Fertility preservation in women-a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin’s lymphoma and borderline ovarian tumours by the fertility preservation network FertiPROTEKT. Arch Gynecol Obstet. 2011;284(2):427–35.

    Article  Google Scholar 

  45. von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM, Strowitzki T. Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril. 2009;92(4):1360–5.

    Article  Google Scholar 

  46. Dolmans MM, Demylle D, Martinez-Madrid B, Donnez J. Efficacy of in vitro fertilization after chemotherapy. Fertil Steril. 2005;83(4):897–901.

    Article  PubMed  Google Scholar 

  47. Meirow D, Schiff E. Appraisal of chemotherapy effects on reproductive outcome according to animal studies and clinical data. J Natl Cancer Inst Monogr. 2005;34:21–5.

    Article  PubMed  CAS  Google Scholar 

  48. Oktay K, Hourvitz A, Sahin G, Oktem O, Safro B, Cil A, Bang H. Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer ­undergoing ovarian stimulation before chemotherapy. J Clin Endocrinol Metab. 2006;91(10): 3885–90.

    Article  PubMed  CAS  Google Scholar 

  49. Oktay K, Buyuk E, Libertella N, Akar M, Rosenwaks Z. Fertility preservation in breast cancer patients: a prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation. J Clin Oncol. 2005;23(19):4347–53.

    Article  PubMed  CAS  Google Scholar 

  50. Azim AA, Costantini-Ferrando M, Oktay K. Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study. J Clin Oncol. 2008;26(16):2630–5.

    Article  PubMed  CAS  Google Scholar 

  51. Oktay K, Turkcuoglu I, Rodriguez-Wallberg KA. GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor/FSH stimulation. Reprod Biomed Online. 2010;20(6):783–8.

    Article  PubMed  CAS  Google Scholar 

  52. Tulandi T, et al. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil Steril. 2006;85(6):1761–5.

    Article  PubMed  CAS  Google Scholar 

  53. Kolibianakis EM, Venetis CA, Tarlatzis BC. Cryopreservation of human embryos by vitrification or slow freezing: which one is better? Curr Opin Obstet Gynecol. 2009;21(3):270–4.

    Article  PubMed  Google Scholar 

  54. Chen C. Pregnancy after human oocyte cryopreservation. Lancet. 1986;1:884–6.

    Article  PubMed  CAS  Google Scholar 

  55. Oktay K, Cil AP, Bang H. Efficiency of oocyte cryopreservation: a meta-analysis. Fertil Steril. 2006;86(1):70–80.

    Article  PubMed  Google Scholar 

  56. Cobo A, Diaz C. Clinical application of oocyte vitrification: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2011;96(2):277–85.

    Article  PubMed  Google Scholar 

  57. Cobo A, Domingo J, Pérez S, Crespo J, Remohí J, Pellicer A. Vitrification: an effective new approach to oocyte banking and preserving fertility in cancer patients. Clin Transl Oncol. 2008;10(5):268–73.

    Article  PubMed  CAS  Google Scholar 

  58. Cobo A, Meseguer M, Remohí J, Pellicer A. Use of cryo-banked oocytes in an ovum donation programme: a prospective, randomized, controlled, clinical trial. Hum Reprod. 2010;25(9):2239–46.

    Article  PubMed  Google Scholar 

  59. Chian RC, Huang JY, Tan SL, Lucena E, Saa A, Rojas A, Ruvalcaba Castellón LA, García Amador MI, Montoya Sarmiento JE. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed Online. 2008;16(5):608–10.

    Article  PubMed  Google Scholar 

  60. Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online. 2009;18(6):769–76.

    Article  PubMed  CAS  Google Scholar 

  61. Yang D, Brown SE, Nguyen K, Reddy V, Brubaker C, Winslow KL. Live birth after the transfer of human embryos developed from cryopreserved oocytes harvested before cancer treatment. Fertil Steril. 2007;87(6):1469e1–4.

    Article  Google Scholar 

  62. Fasano G, Moffa F, Dechène J, Englert Y, Demeestere I. Vitrification of in vitro matured oocytes collected from antral follicles at the time of ovarian tissue cryopreservation. Reprod Biol Endocrinol. 2011;23:9–15.

    Google Scholar 

  63. Huang JY, Tulandi T, Holzer H, Tan SL, Chian RC. Combining ovarian tissue cryobanking with retrieval of immature oocytes followed by in vitro maturation and vitrification: an additional strategy of fertility preservation. Fertil Steril. 2008;89(3):567–72.

    Article  PubMed  Google Scholar 

  64. Revel A, Revel-Vilk S, Aizenman E, Porat-Katz A, Safran A, Ben-Meir A, Weintraub M, Shapira M, Achache H, Laufer N. At what age can human oocytes be obtained? Fertil Steril. 2009;92(2):458–63.

    Article  PubMed  Google Scholar 

  65. Chian RC, Buckett WM, Tan SL. In-vitro maturation of human oocytes. Reprod Biomed Online. 2004;8(2):148–66.

    Article  PubMed  Google Scholar 

  66. Maman E, Meirow D, Brengauz M, Raanani H, Dor J, Hourvitz A. Luteal phase oocyte retrieval and in vitro maturation is an optional procedure for urgent fertility preservation. Fertil Steril. 2011;95(1):64–7.

    Article  PubMed  Google Scholar 

  67. Moria A, Das M, Shehata F, Holzer H, Son WY, Tulandi T. Ovarian reserve and oocyte maturity in women with malignancy undergoing in vitro maturation treatment. Fertil Steril. 2011;95(5):1621–3.

    Article  PubMed  Google Scholar 

  68. Jadoul P, Dolmans MM, Donnez J. Fertility preservation in girls during childhood: is it feasible, efficient and safe and to whom should it be proposed? Hum Reprod Update. 2010;16(6):617–30.

    Article  PubMed  Google Scholar 

  69. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, Martinez-Madrid B, van Langendonckt A. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364(9443): 1405–10.

    Article  PubMed  CAS  Google Scholar 

  70. Dittrich R, Lotz L, Keck G, Hoffmann I, Mueller A, Beckmann MW, van der Ven H, Montag M. Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation. Fertil Steril. 2011;97(2):387–90.

    Article  PubMed  Google Scholar 

  71. Donnez J, Silber S, Andersen CY, Demeestere I, Piver P, Meirow D, Pellicer A, Dolmans MM. Children born after autotransplantation of cryopreserved ovarian tissue. A review of 13 live births. Ann Med. 2011;43(6):437–50.

    Article  PubMed  Google Scholar 

  72. Revel A, Laufer N, Ben Meir A, Lebovich M, Mitrani E. Micro-organ ovarian transplantation enables pregnancy: a case report. Hum Reprod. 2011;26:1097–103.

    Article  PubMed  Google Scholar 

  73. Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, Schmidt KL, Andersen AN, Ernst E. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23(10):2266–72.

    Article  PubMed  Google Scholar 

  74. Dolmans MM, Donnez J, Camboni A, Demylle D, Amorim C, Van Langendonckt A, Pirard C. IVF outcome in patients with orthotopically transplanted ovarian tissue. Hum Reprod. 2009;24(11):2778–87.

    Article  PubMed  Google Scholar 

  75. Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, Schiff E, Dor J. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353(3):318–21.

    Article  PubMed  CAS  Google Scholar 

  76. Dolmans MM, Marinescu C, Saussoy P, Van Langendonckt A, Amorim C, Donnez J. Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is not safe. Blood. 2010;116:2908–14.

    Article  PubMed  CAS  Google Scholar 

  77. Meirow D, Hardan I, Dor J, Fridman E, Elizur S, Ra’anani H, Sluyusarevsky E, Amariglio N, Schiff E, Rechavi G, Nagler A, Ben Yehuda D. Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. Hum Reprod. 2008;23:1007–13.

    Article  PubMed  Google Scholar 

  78. Rosendahl M, Andersen MK, Ralfkiaer E, Kjeldsen L, Andersen MK, Andersen CY. Evidence of residual disease in cryopreserved ovarian cortex from female patients with leukemia. Fertil Steril. 2010;94:2186–90.

    Article  PubMed  Google Scholar 

  79. Amorim CA, Van Langendonckt A, David A, Dolmans MM, Donnez J. Survival of human pre-antral follicles after cryopreservation of ovarian tissue, follicular isolation and in vitro culture in a calcium alginate matrix. Hum Reprod. 2009;24:92–9.

    Article  PubMed  CAS  Google Scholar 

  80. Hovatta O, Wright C, Krausz T, Hardy K, Winston RML. Human primordial, primary and secondary ovarian follicles in long-term culture: effect of partial isolation. Hum Reprod. 1999;14:2519–24.

    Article  PubMed  CAS  Google Scholar 

  81. Hovatta O. Cryopreservation and culture of human ovarian cortical tissue containing early follicles. Review. Eur J Obstet Gynecol Reprod Biol. 2004;113:S50–4.

    Article  PubMed  Google Scholar 

  82. Telfer EE, McLaughlin M, Ding C, Thong KJ. A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin. Hum Reprod. 2008;23:1151–8.

    Article  PubMed  CAS  Google Scholar 

  83. Dolmans MM, Martinez-Madrid B, Gadisseux E, Guiot Y, Yuan WY, Torre A, Camboni A, Van Langendonckt A, Donnez J. Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice. Reproduction. 2007;134: 253–62.

    Article  PubMed  CAS  Google Scholar 

  84. Dolmans MM, Yuan WY, Camboni A, Torre A, Van Langendonckt A, Martinez-Madrid B, Donnez J. Development of antral follicles after xenografting of isolated small human preantral follicles. Reprod Biomed Online. 2008;16:705–11.

    Article  PubMed  Google Scholar 

  85. Abir R, Franks S, Mobberley MA, Moore PA, Margara RA, Winston RM. Mechanical isolation and in vitro growth of preawntral and small antral human follicles. Fertil Steril. 1997;68:682–8.

    Article  PubMed  CAS  Google Scholar 

  86. Jeruss JS, Woodruff TK. Preservation of fertility in patients with cancer. N Engl J Med. 2009;360:902–11.

    Article  PubMed  CAS  Google Scholar 

  87. Telfer EE, McLaughlin M. In vitro development of ovarian follicles. Semin Reprod Med. 2011;29:15–23.

    Article  PubMed  CAS  Google Scholar 

  88. Ding CC, Thong KJ, Krishna A, Telfer EE. Activin A inhibits activation of human primordial follicles in vitro. J Assist Reprod Genet. 2010;27:141–7.

    Article  PubMed  Google Scholar 

  89. McLaughlin M, Telfer EE. Oocyte development in bovine primordial follicles is promoted by activin and FSV within a two-step serum-free culture. Reproduction. 2010;139(6):971–8. Epub 2010 mar 5.

    Article  PubMed  Google Scholar 

  90. Aubard Y, Piver P, Pech JC, Galinat S, Teissier MP. Ovarian tissue cryopreservation and gynecologic oncology: a review. Eur J Obstet Gynecol Reprod Biol. 2001;97:5–14.

    Article  PubMed  CAS  Google Scholar 

  91. Morice P, Juncker L, Rey A, El-Hassan J, Haie-Meder C, Castaigne D. Ovarian transposition for patients with cervical carcinoma treated by radiosurgical combination. Fertil Steril. 2000;74:743–8.

    Article  PubMed  CAS  Google Scholar 

  92. Scott SM, Schlaff W. Laparoscopic medial oophoropexy prior to radiation therapy in an adolescent with Hodgkin’s disease. J Pediatr Adolesc Gynecol. 2005;18:355–7.

    Article  PubMed  Google Scholar 

  93. Thibaud E, Ramirez M, Brauner R, Flamant F, Zucker JM, Fekete C, Rappaport R. Preservation of ovarian function by ovarian transposition performed before pelvic irradiation during childhood. J Pediatr. 1992;121:880–4.

    Article  PubMed  CAS  Google Scholar 

  94. Sonmezer M, Oktay K. Fertility preservation in female patients. Hum Reprod Update. 2004;10:251–66.

    Article  PubMed  Google Scholar 

  95. Dudzinski DM. Ethical issues in fertility preservation for adolescent cancer survivors: oocyte and ovarian tissue cryopreservation. J Pediatr Adolesc Gynecol. 2004;17:97–102.

    Article  PubMed  Google Scholar 

  96. Bukovsky A. Can ovarian infertility be treated with bone marrow- or ovary-derived germ cells? Reprod Biol Endocrinol. 2005;3:36.

    Article  PubMed  Google Scholar 

  97. Carely A, Meirow D, Peretz A, Albeck m, Bartoov B, Sredni (2009). Protective effect of the immunomodulator AS101 against cyclophosphmide-induced testicular damage in mice. Jun;24(6):1322–9.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Gynecology, Cliniques Universitaires Saint-Luc and pôle de Recherche en Cognicologié Institut de recherche Experimentale at clinique, Université Catholique de Louvain, Brussels, 1200, Belgium

    Pascale Jadoul M.D., Marie-Madeleine Dolmans M.D., Ph.D. & Jacques Donnez M.D., Ph.D.

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  2. Marie-Madeleine Dolmans M.D., Ph.D.
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  3. Jacques Donnez M.D., Ph.D.
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Correspondence to Marie-Madeleine Dolmans M.D., Ph.D. .

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Editors and Affiliations

  1. and Infertility, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Francis St 75, Boston, 02115, Massachusetts, USA

    Elizabeth S. Ginsburg

  2. and Infertility, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinlogy, Francis St. 75, Boston, 02115, Massachusetts, USA

    Catherine Racowsky

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© 2012 Springer Science+Business Media New York

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Jadoul, P., Dolmans, MM., Donnez, J. (2012). Fertility Preservation. In: Ginsburg, E., Racowsky, C. (eds) In Vitro Fertilization. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9848-4_14

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  • DOI: https://doi.org/10.1007/978-1-4419-9848-4_14

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-9847-7

  • Online ISBN: 978-1-4419-9848-4

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