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Beetle Immunity

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Invertebrate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 708))

Abstract

Genetic studies have elegantly characterized the innate immune response in Drosophila melanogaster. However, these studies have a limited ability to reveal the biochemical mechanisms underlying the innate immune response. To investigate the biochemical basis of how insects recognize invading microbes and how these recognition signals activate the innate immune response, it is necessary to use insects, from which larger amounts of hemolymph can be extracted. Using the larvae from two species of beetle, Tenebrio molitor and Holotrichia diomphalia, we elucidated the mechanisms underlying pathogenic microbe recognition. In addition, we studied the mechanism of host defense molecule amplification. In particular, we identified several pattern recognition proteins, serine proteases, serpins and antimicrobial peptides and examined how these molecules affect innate immunity.

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Authors and Affiliations

  1. National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Busan, Korea

    Ji-Won Park, Chan-Hee Kim, Jiang Rui,  Keun-HwaPark, Kyung-Hwa Ryu, Jun-Ho Chai, Hyun-Ok Hwang, Kenji Kurokawa, Nam-Chul Ha & Bok Luel Lee

  2. Department of Comparative Physiology, Uppsala University, Uppsala, Sweden

    Irene Söderhäll & Kenneth Söderhäll

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  1. Ji-Won Park
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  2. Chan-Hee Kim
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  3. Jiang Rui
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Correspondence to Bok Luel Lee .

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  1. Department of Comparative Physiology, Uppsala University, Uppsala, Sweden

    Kenneth Söderhäll

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Park, JW. et al. (2010). Beetle Immunity. In: Söderhäll, K. (eds) Invertebrate Immunity. Advances in Experimental Medicine and Biology, vol 708. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8059-5_9

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